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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 3 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 4 | 原发灶切除在无症状的、同时性的、转移灶不可切除的结直肠癌患者中的作用:一项多中心随机对照试验显示文摘目的:我们在同时性的、转移灶不可切除的无症状Ⅳ期结直肠癌患者中,评估接受原发灶切除术(primary tumor resection,PTR)续贯化疗的患者相比接受单纯化疗的患者的生存优势。方法:这是一项开放的前瞻性随机对照试验(ClnicalTrials.gov注册号:NCT01978249)。从2013年5月至2016年4月,在12所三级医院中将48例诊断为转移灶不可切除的、原发灶无症状的结直肠癌患者按1:1比例进行随机化分组,其中PTR组26例、化疗组22例。主要终点是两年总生存率,次要终点为与原发灶、PTR相关的并发症发生率以及转变为可切除状态的转化率。 | 卓长华 陈功 PARK E J BAEK J H CHOI G S | 2020 | 结直肠肛门外科2020，26，5： | 8 |
| 5 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 6 | Direct cardiac and vascular action of adrenomedullin in conscious sheep 显示文摘 | PARKES D G MAY C N | 1997 | Br J Pharmacol1997，120，6： | 2 |
| 7 | Foaming of PS/wood-fiber composites using moisture as a blowing agent显示文摘 | Rizvi G Matuana L M Park C B | 2000 | Polymer Engineering and Science2000，40，10： | 2 |
| 8 | A novel system design for continuous processing of plastic/wood-fiber composite foams with improved cell morphology显示文摘 | Rizvi G M Pop-Iliev R Park C B | 2002 | Journal of Cellular Plastics2002，38，5： | 2 |
| 9 | Role-Based Access Control on the Web 显示文摘 | Park J S Sandhu R Ahn G | 2001 | ACM Transactions on Information and Systems Security2001，4，1： | 2 |
| 10 | 显示文摘 | Park T G Hoffman A S | 1992 | J Apply Poly Sci1992，，17： | 2 |
| 11 | Improved serpentine laminating micromixer with enhanced local advection显示文摘 | PARK J M KIM D S KANG T G | 2008 | Microfluidics and Nanofluidics2008，4，6： | 1 |
| 12 | Ultra-rapid freezing of water treatment residuals显示文摘 | Philip J Parke Anthony G Collins | 1999 | Wat Res1999，33，10： | 1 |
| 13 | Calibration of a redundant IMU 显示文摘 | CHO S Y PARK C G | 2004 | AIAA Guidance navigation and Control Conference and Exhibit Providence Rhode Island AIAA2004，2004，： | 1 |
| 14 | IDEA and AR-IDEA: Models for dealing with imprecise data in DEA显示文摘 | Cooper W W Park K S Yu G | 1999 | Management Science1999，45，4： | 1 |
| 15 | Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana显示文摘 | OH S A PARK J H LEE G I PACK K H PARK S K NAM H G | 1997 | Plant Journal1997，12，3： | 1 |
| 16 | Adaptive GOP structure for joint scalable video coding显示文摘 | PARK G H PARK M W JEONG S | 2007 | IEICE Trans on Gommun2007，90，2： | 1 |
| 17 | Kinetics of monodisperse iron oxide nanocrystal formation by “heating-up” process 显示文摘 | Kwon S G Piao Y Z Park J | 2007 | J Am Chem Soc2007，129，12： | 1 |
| 18 | Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid 显示文摘 | Mucida D Park Y Kim G | 2007 | Science2007，317，5835： | 1 |
| 19 | Inactivation of DFR (Dihydroflavonol 4-reductase) gene transcription results in blockage of anthocyanin production in yellow onions (Allium cepa)显示文摘 | KIM S G BINZEL M L PARK S H YOO K S PIKE L M | 2004 | Molecular Breeding2004，14，： | 1 |
| 20 | 显示文摘 | Park S H Yoon C S Kang S G | 2004 | Electrochimica Acta2004，49，4： | 1 |
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