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| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | 门静脉栓塞术4种栓塞材料的对比:猪的实验性研究显示文摘对门静脉栓塞术(PVE)中不同栓塞材料进行评估。20只猪接受左、中PVE.按照栓塞材料分为4组,每组5只,栓塞材料分别为亲水磷酸胆碱、丁酰基氰基丙烯酸酯(NBCA)、亲水凝胶和聚乙烯醇(PVA)颗粒,后者大小50-150μm或700~900μm。在行PVE前、术后即刻及术后第7天行安乐死前对受试动物进行门静脉造影及门脉压力测定。获取楔形的栓塞组织和未栓塞的肝脏进行病理检查。在完全栓塞后7d。受试猪中应用亲水凝胶的1只和应用700~900μm PVA的1只. | T. de Baere A. Denys V. Paradis 郑昊宇(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 9 |
| 3 | Sampling variability of liver fibrosis in chronic hepatitis C显示文摘 | Pierre Bedossa Delphine Dargère Valerie Paradis | 2003 | Hepatology2003，，6： | 6 |
| 4 | Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy显示文摘Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327). | Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre | 2015 | World Journal of Hepatology2015，7，6： | 4 |
| 5 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 2 |
| 6 | Expression of connective tissue growth factor in experimental rat and human liver fibrosis 显示文摘 | Paradis V Dargere D Vidaud M | 1999 | Hepathology1999，30，： | 2 |
| 7 | Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion显示文摘 | Nicolas Poté Fran?ois Cauchy Miguel Albuquerque Hélène Voitot Jacques Belghiti Laurent Castera Hervé Puy Pierre Bedossa Valérie Paradis | 2014 | Journal of Hepatology2014，，： | 2 |
| 8 | Nitrate isotopes unveil distinct seasonal N-sources and the critical role of crop residues in groundwater contamination显示文摘 | Martine M. Savard George Somers Anna Smirnoff Daniel Paradis Eric van Bochove Shawna Liao | 2009 | Journal of Hydrology2009，，1： | 2 |
| 9 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 10 | 用新方法消除根本原因分析中的错误认识显示文摘多年来,我们在质量改进方面所接受的观念是,用一套基于因果关系的工具来查找问题的根本原因。这些工具包括“五问法”(5 Whys,又叫“5个为什么”,通过一系列提问来查找问题的因果关系)和鱼刺图。然而,许多使用这些方法的人发现这些方法并没有能够制止某些问题——特别是由人的差错造成的问题的再次发生。因此他们问道: | 马克·巴拉迪斯(Mark Paradies) 费杨(译) | 2010 | 中国认证认可2010，，12： | 2 |
| 11 | 过度表达的内皮素1通过改变氧化应激加重糖尿病诱导的内皮功能障碍显示文摘内皮素1表达增加引起内皮功能障碍和氧化应激。通常糖尿病患者体内的血浆内皮素1水平增加。鉴于糖尿病患者的内皮功能障碍常先于血管并发症,研究者假设在血管内皮细胞中,内皮素1的过度表达会加莺糖尿病引起的血管内皮功能障碍。 | Idris-Khodja N Ouerd S Mian MO Gornitsky J Barhoumi T Paradis P Schiffrin EL 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 12 | 肾上腺素在心肺复苏中的应用显示文摘拟肾上腺素药的作用机制复苏早期应用肾上腺素可使自主循环恢复的可能性明显增加。Otto等在电机械分离(EMD)的模型预先用α受体阻滞药(酚苄明)处理,再用纯β受体兴奋药异丙肾上腺素复苏,自主循环恢复仅占27%,而单纯用肾上腺素复苏者自主循环100%恢复。自主循环恢复表明心肌内氧的利用与代谢需求的比值已达到最大限度,推测心肌血流量为15~20ml/(min·100g) | Paradis NA Koscove EM 孟庆祥 胡振芳 | 1992 | 国外医学(麻醉学与复苏分册)1992，13，2： | 2 |
| 13 | 脑干躯体感觉系统的扩散张量纤维束成像:3.0T各向同性高空间分辨力成像表现的初探显示文摘由于既往无创性检查的敏感度及空间分辨力的不足,因此制约了对不同躯体感觉通路(内侧丘系和脊髓丘系)的显示。本研究采用各向同性高空间分辨力的扩散张量成像(DTI)和基于DTI的3D纤维束成像技术.探讨其是否可促进对健康成人脑干躯体感觉系统的解剖研究。5例健康男性(24~37岁)被纳入本研究,并获得知情同意。为对脑干内感觉传导通路进行描绘及定量分析.采用3.0TMR行高空间分辨力神经纤维连续追踪技术(FACT)的扩散张量纤维束成像(DTT), | T. de Baere A. Denys V. Paradis 郑昊宇(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 2 |
| 14 | Rating chronic medical illness burden in geropsyehiatric practice and research: application of the Cumulative Illness Rating Scale显示文摘 | Miller M D Paradis C F Houck P R | 1992 | Psychiatry Res1992，41，3： | 1 |
| 15 | Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo显示文摘 | Goodell M A Brose K Paradis G | 1996 | J Exp Med1996，183，4： | 1 |
| 16 | Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay 显示文摘 | BIECHE I NOGUES C PARADIS V | 2000 | Clin Cancer Res2000，6，2： | 1 |
| 17 | E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms显示文摘 | Chen H Paradies NE Fedor-Chaiken M | 1997 | J Cell Sci1997，110，3： | 1 |
| 18 | Lipid peroxidation and aGerations to oxidative metabolism in mitochondria isolated from rat heart subi jected to isehemia and reperfusion显示文摘 | ParadieS G Pettosillo G Pistolese M | 1999 | Free Radic Biol Med1999，27，12： | 1 |
| 19 | Effects and regulation of connective tissue growth factor on hepatic stellate cells显示文摘 | Paradis V Dargere D Bonvoust F | 2002 | Lab Invest2002，82，： | 1 |
| 20 | The standard and high dose epinephrine, coronary perfusion pressure during prolonged cardiopulmonary resuscitation 显示文摘 | Paradis NA Martion CB River EP | 1991 | J Am Med Assoc1991，2650，： | 1 |
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