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50篇 您的检索式:作者名="Overholtzer"
    题名 作者 年代 出处 被引量
1Induction of entosis by epithelial cadherin expression显示文摘房间吞没典型地从后生动物的纸巾为清理指向死了或死的房间。然而,最近的证据证明实时房间能也被指向并且吞没能引起房间死亡。Entosis 是建议调停的一机制吞没并且由他们的邻居,实时肿瘤房间杀死是经常指的一项活动房间同类相食。这里,我们报导在缺乏上皮的 cadherins 的内长的表示的人的胸肿瘤房间的外长的上皮的 cadherin 蛋白质(E-cadherin) 或 P-cadherin ) 的表示导致 entosis 并且禁止转变生长。cadherin 表示导致的 Entosis 在耳中的房间以内与 Rho 和 Rho-kinase (岩石) 活动的极化的分发被联系,它依赖于 p190A RhoGAP 活动。p190A RhoGAP 表示的岩石抑制或 downregulation 减少 entosis 并且增加上皮的表示 cadherin 肿瘤房间的转变生长。这些数据为 entosis 的学习定义新房间系统,并且作为被上皮的粘附的建立导致并且禁止转变生长的房间同类相食的机制识别 entosis。Qiang Sun Edmund S Cibas Hongyan Huang Louis Hodgson Michael Overholtzer 2014Cell Research2014,24,11:10
2Competition between human cells by entosis显示文摘人的癌由被知道为营养素和生长因素间接地竞争的肿瘤房间的复杂混合物组成。肿瘤房间是否能也直接竞争,例如由对手的消除,不被知道。这里,我们证明人的房间能直接由称为 entosis 的吞没的机制竞争。由 entosis,当时,房间被吞没,或吃活,并且随后经历房间死亡。我们发现吞没的身份(“ winner”) 并且吞没(“ loser”) 房间被 RhoA 和肌动球朊控制的机械 deformability 支配,有高 deformability 的肿瘤房间在此优先地吞没并且 outcompete 有在异构的人口的低 deformability 的附近的房间。我们进一步发现那激活的 Kras 并且 Rac 发信号由 downregulating 给予获胜者地位到房间可收缩的肌浆球蛋白,允许最后经历房间死亡的附近的房间的成为主观。最后,我们计算 cell-in-cell 形成的精力风景,表明那一机械在获胜者和输家房间之间微分被要求让 entosis 继续。这些数据在发生在人的肿瘤的哺乳动物的房间定义竞争的机制。Qiang Sun Tianzhi Luo Yixin Ren Oliver Florey Senji Shirasawa Takehiko Sasazuki Douglas N Robinson Michael Overholtzer 2014Cell Research2014,24,11:8
3LAP: the protector against autoimmunity显示文摘Urmi Bandyopadhyay Michael Overholtzer 2016Cell Research2016,26,8:2
4Transforming properties of YAP,a candidate oncogene on the chromosome 11 q22 amplicon显示文摘Overholtzer M Zhang J Smolen GA 0,,:1
5A nonapoptotic cell death process,entosis, that occurs by cell-in-cell invasion显示文摘Overholtzer M Mailleux A A Mouneimne G 2007Cell2007,131,:1
6The use of internal otolith morphometrics for indentification of haddock (Melanogrammus aeglefinus) stocks on Georges Bank显示文摘Gavin A Begg William J Overholtz Nacy J Munroe 2001Fish Bull2001,99,:1
7A non- apoptotic cell death process, entosis, that occurs by cell- in-cell invasion 显示文摘Overholtzer M Mailleux AA Mouneimne G 2007Cell2007,131,5:1
8CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals显示文摘Jin S Kalkum M Overholtzer M 2003Genes Dev2003,17,3:1
9A Nonapop totic cell death process, entosis, that occurs by cell-in-cell inva- sion 显示文摘Overholtzer M Mailleux A A Mouneimne G 2007Cell2007,131,5:1
10In-cell infection: bringing uninvited guests显示文摘Yongchan Lee Michael Overholtzer 2015Cell Research2015,25,6:1
11Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis显示文摘WenYong Chen Timothy K. Cooper Cynthia A. Zahnow Michael Overholtzer Zhiquan Zhao Marc Ladanyi Judith E. Karp Nalan Gokgoz Jay S. Wunder Irene L. Andrulis Arnold J. Levine Joseph L. Mankowski Stephen B. Baylin 2004Cancer Cell2004,,4:1
12Consumption of important pelagic fish and squid by predator fish in the northeastern USA shelf ecosystem with some fishery comparisons显示文摘Overholtz W J Link J S Suslowicz L E 2000ICES J Mar Sci2000,57,:1
13Autophagy in cellular metabolism and cancer显示文摘Jiang Xuejun Overholtzer Michael Thompson Craig B 2015Journal of Clinical Investigation2015,,1:1
14The presence of p53mutations in human osteosarcomas correlates with high levels of genomic instability显示文摘Overholtzer M Rao P H Favis R 2003Proc Natl Acad Sci USA2003,100,11:1
15Trans-forming properties of YAP, a candidate oncogene onthe chromosome 11q22 amp!icon显示文摘Overholtzer M Zhang J Smolen GA 2006Proc Natl AcadSci USA2006,103,12:1
16Transforming properties of YAP,a candidate oncogene on the chromosome 11q22 amplicon显示文摘Overholtzer M Zhang J Smolen GA 2006Proc Natl Acad Sci USA2006,103,12:1
17Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex- dependent and-independent autophagy显示文摘Gammoh N Florey O Overholtzer M 2013Nat Struct Mol Biol2013,20,2:1
18wisp -1 attenuates p53 - me-diated apoptosis in response to DNA damage through activation ofthe Akt kinase显示文摘Su F Overholtzer M Besser D 2002Genes Dev2002,16,1:1
19A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion 显示文摘Overholtzer M Mailleux AA Motmeimne G 2007Cell2007,131,5:1
20Transforming properties of YAP,a candidate oncogene on the chromosome 11q22 amplicon显示文摘Overholtzer M Zhang J Smolen GA 2006Proc Natl Acad Sci USA2006,103,12:1
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