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| 1 | Molecular aspects of intestinal calcium absorption显示文摘Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3steps: the entrance of Ca2+ across the brush border membranes(BBM) of enterocytes through epithelial Ca2+ channels TRPV6, TRPV5, and Cav1.3; Ca2+ movement from the BBM to the basolateral membranes by binding proteins with high Ca2+ affinity(such as CB9k); and Ca2+ extrusion into the blood. Plasma membrane Ca2+ ATPase(PMCA1b) and sodium calcium exchanger(NCX1) are mainly involved in the exit of Ca2+ from enterocytes. A novel molecule, the 4.1R protein, seems to be a partner of PMCA1 b, since both molecules colocalize and interact. The paracellular pathway consists of Ca2+ transport through transmembrane proteins of tight junction structures, such as claudins 2, 12, and 15. There is evidence of crosstalk between the transcellular and paracellular pathways in intestinal Ca2+ transport. When intestinal oxidative stress is triggered, there is a decrease in the expression of several molecules of both pathways that inhibit intestinal Ca2+ absorption. Normalization of redox status in the intestine with drugs such as quercetin, ursodeoxycholic acid, or melatonin return intestinal Ca2+ transport to control values. Calcitriol [1,25(OH)2D3] is the major controlling hormone of intestinal Ca2+ transport. It increases the gene and protein expression of most of the molecules involved in both pathways. PTH, thyroid hormones, estrogens, p ro l a c t i n, g ro w t h h o r m o n e, a n d g l u c o c o r t i c o i d s apparently also regulate Ca2+ transport by direct action, indirect mechanism mediated by the increase of renal 1,25(OH)2D3 production, or both. Different physiological conditions, such as growth, pregnancy, lactation, and aging, adjust intestinal Ca2+ absorption according to Ca2+ demands. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism. | Gabriela Diaz de Barboza Solange Guizzardi Nori Tolosa de Talamoni | 2015 | World Journal of Gastroenterology2015，21，23： | 20 |
| 2 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 3 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 4 | 文献快报(4):童年期不良经历与成年期生理损害的关系--1958年英国出生队列研究显示文摘适应负荷(allostatic load,AL)是一种衡量躯体受到长期压力时所导致生理损害程度的评价工具,这种损害可能部分是由于生命早期不良经历所致,因此这个指标通常可作为评价慢性应激暴露水平的生物标志物。Barboza Solís C等通过对童年期不良经历(adverse childhood experiences,ACEs)与中年期适应负荷关系的研究来进一步验证远期不良经历可导致生理功能损害的研究假设。该课题组利用1958年英国出生队列,其中女性3 782人,男性3 753人,共随访了7次。在儿童7岁、11岁和16岁时分别调查了童年期不良经历;在队列人群44岁时,采用神经内分泌系统、免疫与炎症系统、代谢系统、呼吸与心血管系统4个系统14个指标作为评价其适应负荷的可操作性指标,同时调查了健康行为、 | BARBOZA SOLíS C KELLY-IRVING M FANTIN R 苏普玉 | 2015 | 中国学校卫生2015，36，3： | 3 |
| 5 | 有氧运动联合阻抗运动对难治性高血压患者动态血压的降低作用更为持久:一项随机交叉试验显示文摘该研究比较有氧运动、阻抗运动及联合运动对难治性高血压(refractory hypertension,RH)和非难治性高血压(NON-RH)患者血压的短期影响。方法:招募患者20例(RH 10例和NON-RH 10例),随机进行三种运动训练或对照训练。试验训练结束后监测24h动态血压。结果:RH患者在有氧运动、阻抗运动及联合运动后动态血压降低。联合运动后日间和夜间动态血压均降低。有氧运动对日间血压的影响更为显著,而阻抗运动降低夜间血压的幅度较大。仅阻抗运动降低NON-RH患者的收缩压,三种运动均可降低舒张压。 | 袁源(摘译) 练桂丽(审校) Pires NF Coelho-Júnior HJ Gambassi BB deFaria APC Ritter AMV de Andrade Barboza C Ferreira-Melo SE Rodrigues B Júnior HM | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 6 | Methane Direct Conversion on Mo/ZSM-5 Catalysts Modified by Pd and Ru显示文摘到在甲烷的 dehydroaromatization 使用的 Mo/HZSM-5 催化剂的 Ru 和 Pd 的增加的效果被调查。催化测试和规划温度的氧化结果证明基于 Pd 的催化剂对萘更选择并且承受了强壮的释放。因为 Mo2C 表面的保护的机制, Ru 的存在可能改进了这项活动和稳定性,与在碳质沉积的减少。给词调音:甲烷;Pd;Ru;瞬间;ZSM-5; | Priscila Dias Sily Fabio Bellot Noronha Fabio Barboza Passos | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 7 | Altered T cell costimula- tion during chronic hepatitis B infection 显示文摘 | Barboza L Salmen S Darrell L | 2009 | Cell Immunol2009，257，12： | 1 |
| 8 | What Kind of Message Does IL-12 /IL-23 Bring to Maerophages and Dendritic Ceils? 显示文摘 | Bastos K R Marinho C R Barboza R | 2004 | Microbes and Infection2004，6，6： | 1 |
| 9 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 10 | Dynamics of a hyperchaotic Lorenz system显示文摘 | Barboza R | 2007 | International Journal of Bifurcation and Chaos2007，17，12： | 1 |
| 11 | New perspectivesin melatonin uses显示文摘 | Carpentieri A Diaz de Barboza G Areco V | 2012 | Pharmacol Res2012，65，4： | 1 |
| 12 | Anxiety,depression,and quality of life in German ambulatory breast cancer patients显示文摘 | Schleife H Sachtleben C Barboza C F | 2014 | Breast Cancer2014，21，8： | 1 |
| 13 | Glycosyla-tion of human milk lactoferrin exhibits dynamic changes dur-ing early lactation enhancing its role in pathogenic bacteria-host interactions 显示文摘 | Barboza M Pinzon J Wickramasinghe S | 2012 | Molecular Cellular Proteomics2012，11，6： | 1 |
| 14 | Determination of alcohol content in beverages using short-wave near-infrared spectroscopy and temperature correction by transfer calibration procedures 显示文摘 | Fernando D Barboza · Ronei J | 2003 | Poppi Anal Bioanal Chem2003，377，4： | 1 |
| 15 | Bacteroides in the infant gut consume milk oligosaccharides viamucus-utilization pathways显示文摘 | MARCOBAL A BARBOZA M SONNENBURG E D | 2011 | Cell Host & Microbe2011，10，5： | 1 |
| 16 | Cost-benefits of vaccination against hepatitis B inhospital personal in venezuela显示文摘 | Fernandez Barboza R Rivero D Echeverria B | 1991 | Bol-Oficina-Sanit-Panam1991，111，1： | 1 |
| 17 | Measurement of intestinalpermeability using mannitol and lactulose in children with diarrheal diseases显示文摘 | Barboza Junior MS Silva MS Guerrant RL | 1999 | Braz J Med Biol Res1999，32，12： | 1 |
| 18 | Identification of growthhormone receptor in localized neurofibromas of patients withneurofibromatosis type 1 显示文摘 | Cunha KS Barboza EP Fonseca EC | 2003 | J Clin Pathol2003，56，： | 1 |
| 19 | Correlation network analysis shows divergent effects of a long-term,high-fat diet and exercise on early stage osteoarthritis phenotypes in mice显示文摘Background:Obesity increases knee osteoarthritis(OA) risk through metabolic,inflammatory,and biomechanical factors,but how these systemic and local mediators interact to drive OA pathology is not well understood.We tested the effect of voluntary running exercise after chronic diet-induced obesity on knee OA-related cartilage and bone pathology in mice.We then used a correlation-based network analysis to identify systemic and local factors associated with early-stage knee OA phenotypes among the different diet and exercise groups.Methods:Male C57 BL/6 J mice were fed a defined control(10% kcal fat) or high fat(HF)(60% kcal fat) diet from 6 to 37 weeks of age.At 25 weeks,one-half of the mice from each diet group were housed in cages with running wheels for the remainder of the study.Histology,micro computed tomography,and magnetic resonance imaging were used to evaluate changes in joint tissue structure and OA pathology.These local variables were then compared to systemic metabolic(body mass,body fat,and glucose tolerance),inflammatory(serum adipokines and inflammatory mediators),and functional(mechanical tactile sensitivity and grip strength) outcomes using a correlation-based network analysis.Diet and exercise effects were evaluated by two-way analysis of variance.Results:An HF diet increased the infrapatellar fat pad size and posterior joint osteophytes,and wheel running primarily altered the subchondral cortical and trabecular bone.Neither HF diet nor exercise altered average knee cartilage OA scores compared to control groups.However,the coefficient of variation was≥25% for many outcomes,and some mice in both diet groups developed moderate OA(>33% maximum score).This supported using correlation-based network analyses to identify systemic and local factors associated with early-stage knee OA phenotypes.In wheel-running cohorts,an HF diet reduced the network size compared to the control diet group despite similar running distances,suggesting that diet-induced obesity dampens the effects of exercise on systemic and local OA-related factors.Each of the 4 diet and activity groups showed mostly unique networks of local and systemic factors correlated with early-stage knee OA.Conclusion:Despite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations,diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA.These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease. | Timothy M.Griffin Albert Batushansky Joanna Hudson Erika Barboza Prado Lopes | 2020 | Journal of Sport and Health Science2020，9，2： | 1 |
| 20 | Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1 显示文摘 | Cunha KS Barboza EP Da Fonseca EC | 2003 | J Clin Pathol2003，56，： | 1 |
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