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| 1 | ACE2/Ang-(1-7) signaling and vascular remodeling显示文摘The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling. | ZHANG ZhenZhou CHEN LaiJiang ZHONG JiuChang GAO PingJin OUDIT Gavin Y. | 2014 | Science China(Life Sciences)2014，57，8： | 14 |
| 2 | Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction显示文摘 | JiuChang Zhong Ratnadeep Basu Danny Guo Fung L. Chow Simon Byrns Manfred Schuster Hans Loibner Xiu-hua Wang Josef M. Penninger Zamaneh Kassiri Gavin Y. Oudit | 2010 | Circulation2010，，7： | 2 |
| 3 | Role of Phosphoinositide 3-Kinase α, Protein Kinase C, and L-Type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility显示文摘 | Wenbin Liang Gavin Y. Oudit Mikin M. Patel Ajay M. Shah James R. Woodgett Robert G. Tsushima Michael E. Ward Peter H. Backx | 2010 | Hypertension2010，，： | 1 |
| 4 | Angiotensin‐converting enzyme 2 antagonizes angiotensin II‐induced pressor response and NADPH oxidase activation in Wistar–Kyoto rats and spontaneously hypertensive rats显示文摘 | Jennifer Lo Vaibhav B. Patel Zuocheng Wang Jody Levasseur Susan Kaufman Josef M. Penninger Gavin Y. Oudit | 2012 | Experimental Physiology2012，，1： | 1 |
| 5 | Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS显示文摘 | Vaibhav B. Patel Nicola Clarke Zuocheng Wang Dong Fan Nirmal Parajuli Ratnadeep Basu Brendan Putko Zamaneh Kassiri Anthony J. Turner Gavin Y. Oudit | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 6 | Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy显示文摘 | Gavin Y. Oudit Maria G. Trivieri Neelam Khaper Peter P. Liu Peter H. Backx | 2006 | Journal of Molecular Medicine2006，，5： | 1 |
| 7 | Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression显示文摘 | Jiu-Chang Zhong Jia-ying Ye Hai-yan Jin Xi Yu Hui-min Yu Ding-liang Zhu Ping-jin Gao Dong-yang Huang Manfred Shuster Hans Loibner Jun-min Guo Xi-yong Yu Bing-xiu Xiao Zhao-hui Gong Josef M. Penninger Gavin Y. Oudit | 2010 | Regulatory Peptides2010，，1： | 1 |
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