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| 1 | Novel 3-dimensional virtual hepatectomy simulation combined with real-time deformation显示文摘AIM:To develop a novel 3-dimensional(3D) virtual hepatectomy simulation software,Liversim,to visualize the real-time deformation of the liver.METHODS:We developed a novel real-time virtual hepatectomy simulation software program called Liversim. The software provides 4 basic functions:viewing 3D models from arbitrary directions,changing the colors and opacities of the models,deforming the models based on user interaction,and incising the liver parenchyma and intrahepatic vessels based on user operations. From April 2010 through 2013,99 patients underwent virtual hepatectomies that used the conventional software program SYNAPSE VINCENT preoperatively. Between April 2012 and October 2013,11 patients received virtual hepatectomies using the novel software program Liversim; these hepatectomies were performed both preoperatively and at the same that the actual hepatectomy was performed in an operating room. The perioperative outcomes were analyzed between the patients for whom SYNAPSE VINCENT was used and those for whom Liversim wasused. Furthermore,medical students and surgical residents were asked to complete questionnaires regarding the new software.RESULTS:There were no obvious discrepancies(i.e.,the emergence of branches in the portal vein or hepatic vein or the depth and direction of the resection line) between our simulation and the actual surgery during the resection process. The median operating time was 304 min(range,110 to 846) in the VINCENT group and 397 min(range,232 to 497) in the Liversim group(P = 0.30). The median amount of intraoperative bleeding was 510 m L(range,18 to 5120) in the VINCENT group and 470 m L(range,130 to 1600) in the Liversim group(P = 0.44). The median postoperative stay was 12 d(range,6 to 100) in the VINCENT group and 13 d(range,9 to 21) in the Liversim group(P = 0.36). There were no significant differences in the preoperative outcomes between the two groups. Liversim was not found to be clinically inferior to SYNAPSE VINCENT. Both students and surgical residents reported that the Liversim image was almost the same as the actual hepatectomy.CONCLUSION:Virtual hepatectomy with real-time deformation of the liver using Liversim is useful for the safe performance of hepatectomies and for surgical education. | Yukio Oshiro Hiroaki Yano Jun Mitani Sangtae Kim Jaejeong Kim Kiyoshi Fukunaga Nobuhiro Ohkohchi | 2015 | World Journal of Gastroenterology2015,21,34: | 23 |
| 2 | Radiologic-pathologic correlation of three-dimensional shear-wave elastographic findings in assessing the liver ablation volume after radiofrequency ablation显示文摘AIM: To evaluate the usefulness of three-dimensional(3D) shear-wave elastography(SWE) in assessing the liver ablation volume after radiofrequency(RF) ablation.METHODS: RF ablation was performed in vivo in 10 rat livers using a 15-gauge expandable RF needle. 3D SWE as well as B-mode ultrasound(US) were performed 15 min after ablation. The acquired 3D volume data were rendered as multislice images(interslice distance: 1.10 mm), and the estimated ablation volumes were calculated. The 3D SWE findings were compared against digitized photographs of gross pathological and histopathological specimens of the livers obtained in the same sectional planes as the 3D SWE multislice images. The ablation volumes were also estimated by gross pathological examination of the livers, and theresults were then compared with those obtained by 3D SWE.RESULTS: In B-mode US images, the ablation zone appeared as a hypoechoic area with a peripheral hyperechoic rim; however, the findings were too indistinct to be useful for estimating the ablation area. 3D SWE depicted the ablation area and volume more clearly. In the images showing the largest ablation area, the mean kPa values of the peripheral rim, central zone, and nonablated zone were 13.1 ± 1.5 kPa, 59.1 ± 21.9 kPa, and 4.3 ± 0.8 kPa, respectively. The ablation volumes depicted by 3D SWE correlated well with those estimated from gross pathological examination(r2 = 0.9305, P = 0.00001). The congestion and diapedesis of red blood cells observed in histopathological examination were greater in the peripheral rim of the ablation zone than in the central zone.CONCLUSION: 3D SWE outperforms B-mode US in delineating ablated areas in the liver and is therefore more reliable for spatially delineating thermal lesions created by RF ablation. | Katsutoshi Sugimoto Hisashi Oshiro Saori Ogawa Mitsuyoshi Honjo Takeshi Hara Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014,20,33: | 9 |
| 3 | Three-dimensional imaging identified the accessory bile duct in a patient with cholangiocarcinoma显示文摘The development of diagnostic imaging technology, such as multidetector computed tomography(MDCT) and magnetic resonance cholangiopancreatography(MRCP), has made it possible to obtain detailed images of the bile duct. Recent reports have indicated that a 3-dimensional(3D) reconstructed imaging system would be useful for understanding the liver anatomy before surgery. We have investigated a novel method that fuses MDCT and MRCP images. This novel system easily made it possible to detect the anatomical relationship between the vessels and bile duct in the portal hepatis. In this report, we describe a very rare case of extrahepatic cholangiocarcinoma associated with an accessory bile duct from the caudate lobe connecting with the intrapancreatic bile duct. We were unable to preoperatively detect this accessory bile duct using MDCT and MRCP. However, prior to the second operation, we were able to clearly visualise the injured accessory bile duct using our novel 3D imaging modality. In thisreport, we suggest that this imaging technique can be considered a novel and useful modality for understanding the anatomy of the portal hepatis, including the hilar bile duct. | Ryoichi Miyamoto Yukio Oshiro Shinji Hashimoto Keisuke Kohno Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2014 | World Journal of Gastroenterology2014,20,32: | 6 |
| 4 | Association between Diabetes Mellitus and Oral Health Status in Japanese Adults显示文摘Aim The objective of this study was to analyze the oral health among Japanese adults, with and without diabetes mellitus. Methodology The subjects were 518 community residents aged 20 to 91 years in Japan, who participated in the 'Akita health and nutrition survey' and the 'Akita dental disease survey', conducted in 2006. The surveys comprised a self-administered questionnaire, along with medical and dental examinations. Results Using the community periodontal index (CPI), the mean numbers of sextants presenting codes 0, 1 and 2 were significantly lower in diabetics than non-diabetics among the 59 years or younger age group. Although the mean numbers of sextants with codes 0, 1 and 2 among the 60 to 69 years age group were lower, and sextants with a code X among the 59 years or younger age group were higher in diabetics than non-diabetics, no statistically significant differences were detected. The tendency of lower mean numbers of natural teeth and functional tooth units in diabetics than non-diabetics was observed, however no differences were statistically significant. Conclusion The outcome of periodontal disease seemed to be influenced by the diabetic state to some degree, but a clear association between diabetes and oral health status was not found. | Masayuki Ueno Susumu Takeuchi Akiko Oshiro Kayoko Shinada Satoko Ohara Yoko Kawaguchi | 2010 | International Journal of Oral Science2010,2,2: | 6 |
| 5 | Pedunculated Brunner's gland hamartoma of the duodenum causing upper gastrointestinal hemorrhage显示文摘A case of pedunculated Brunner's gland hamartoma(BGH) of the duodenum causing upper gastrointestinal(GI) hemorrhage is reported.The patient was a 47-year-old man who visited our hospital for further evaluation of tarry stools and shortness of breath.Endoscopic examination of the upper digestive tract revealed a large peduncular polyp with bleeding,about 30 mm in diameter,arising from the wall of the second portion of the duodenum.GI bleeding occurred from the base of the stalk of the polyp.Endoscopic polypectomy was performed.Histological examination of the specimen revealed that the main body of the polyp contained several lobules of mature Brunner's gland with areas of cystic dilatation.The surface epithelium consisted of normal duodenal mucosa with areas of focal ulceration.This polyp was diagnosed as a BGH.The symptom of tarry stools resolved after endoscopic resection.Our case shows that treatment is necessary for duodenal BGH if GI bleeding occurs. | Shoji Hirasaki Motoharu Kubo Atsushi Inoue Yasuyuki Miyake Hisako Oshiro | 2009 | World Journal of Gastroenterology2009,15,3: | 3 |
| 6 | Jejunal small ectopic pancreas developing into jejunojejunal intussusception:A rare cause of ileus显示文摘Intussusception is rare in adults. We describe a 62-year-old man with jejunal ectopic pancreas that led to jejunojejunal intussusception and ileus. The patient was admitted to our hospital because of intermittent abdominal pain. Plain abdominal radiography showed some intestinal gas and fluid levels. Abdominal CT scan demonstrated a target sign suggesting bowel intussusception. Jejunography using a naso-jejunal tube showed an oval-shaped mass about 15 mm in diameter with a smooth surface in the jejunum, which suggested a submucosal tumor (SMT), and edematous mucosa around the mass. Partial jejunal resection was carried out and the resected oval-shaped tumor, 14 mm×11 mm in size, was found to be covered with normal jejunal mucosa. The tumor was histologically diagnosed as type ectopic pancreas according to the classification proposed by Heinrich.Abdominal pain resolved postoperatively.This case reminds us that jejunal ectopic pancreas should be included in the differential diagnosis of intussusception caused by an SMT in the intestine. | Shoji Hirasaki Motoharu Kubo Atsushi Inoue Yasuyuki Miyake Hisako Oshiro | 2009 | World Journal of Gastroenterology2009,15,31: | 3 |
| 7 | A novel preoperative fusion analysis using three-dimensional MDCT combined with three-dimensional MRI for patients with hilar cholangiocarcinoma显示文摘 | Yukio Oshiro Ryoko Sasaki Katsuhiro Nasu Nobuhiro Ohkohchi | 2013 | Clinical Imaging2013,,4: | 2 |
| 8 | Risk factors for postoperative stoma outlet obstruction in ulcerativecolitis显示文摘BACKGROUND Current medical treatments can achieve remission of ulcerative colitis (UC).Surgery is required when potent drug treatment is ineffective or when coloncancer or high-grade dysplasia develops. The standard procedure is restorativeproctocolectomy (RPC) with ileal pouch-anal anastomosis, commonly performedas two- or three-stage RPC with diverting ileostomy. Postoperative stoma outletobstruction (SOO) is frequent, but the causes are not well known.AIM To identify the risk factors for SOO after stoma surgery in patients with UC.METHODS We retrospectively reviewed the files of 148 consecutive UC patients whounderwent surgery with stoma construction. SOO was defined as small bowelobstruction symptoms and intestinal dilatation just below the penetrating part ofthe stoma on computed tomography. Patients were divided into two groups:Those who developed SOO within 30 d after surgery and those who did not.Patient characteristics, intraoperative parameters, the stoma site, and rectusabdominis muscle thickness were collected. Moreover, we identified the patientswho repeatedly developed SOO. Univariate and multivariate analyses wereperformed to identify risk factors for SOO and recurring SOO.RESULTS Eighty-nine patients who underwent two-stage RPC were included betweenJanuary 2008 and March 2020. Postoperatively, SOO occurred in 25 (16.9%)patients after a median time of 9 d (range 2-26). Compared to patients withoutSOO, patients with SOO had a significantly higher rate of malignant tumors ordysplasia (36.0% vs 17.1%, P = 0.032), lower total glucocorticoid dose one monthbefore surgery (0 mg vs 0 mg, P = 0.026), higher preoperative total protein level(6.8 g/dL vs 6.3 g/dL, P = 0.048), higher rate of loop ileostomy (88.0% vs 55.3%, P= 0.002), and higher maximum stoma drainage volume (2300 mL vs 1690 mL, P =0.004). Loop ileostomy (OR = 6.361;95%CI 1.322–30.611;P = 0.021) and maximumstoma drainage volume (OR = 1.000;95%CI 1.000–1.001;P = 0.015) wereconfirmed as independent risk factors for SOO. Eighteen patients with SOO weretreated conservatively without recurrence (sSOO group). Seven (28.0%) patientsrepeatedly developed SOO (rSOO group) during the observation period. Asignificant difference was observed in the rectus abdominis muscle thicknessbetween the two groups (sSOO 9.3 mm, rSOO 12.7 mm, P = 0.006). Musclethickness was confirmed as an independent risk factor for recurring SOO (OR =2.676;95%CI 1.176-4.300;P = 0.008).CONCLUSION In this study, high maximum stoma drainage volume and loop ileostomy areindependent risk factors for SOO. Additionally, among patients with a thickrectus abdominis muscle, the risk of SOO recurrence is high. | Tomoaki Kitahara Yu Sato Takashi Oshiro Rie Matsunaga Makoto Nagashima Shinichi Okazumi | 2020 | World Journal of Gastrointestinal Surgery2020,12,12: | 2 |
| 9 | Intracorporeal circular-stapled esophagojejunostomy using hand-sewn purse-string suture after laparoscopic total gastrectomy显示文摘 | Takahiro Kinoshita Takashi Oshiro Katsuhiko Ito Hidehito Shibasaki Shinichi Okazumi Ryoji Katoh | 2010 | Surgical Endoscopy2010,,11: | 2 |
| 10 | Sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery:A case report显示文摘We report a case of sporadic gastric carcinoid tumor successfully treated by two-stage laparoscopic surgery.A 38-year old asymptomatic woman was referred to our hospital for evaluation of a submucosal tumor of the stomach.Endoscopic examination showed a solitary submucosal tumor without ulceration or central depression on the posterior wall of the antrum and biopsy specimens were not sufficient to determine the diagnosis.Endoscopic ultrasound revealed a tumor nearly 2 cm in diameter arising from the muscle layer and a computed tomography scan showed the tumor enhanced in the arterial phase.Laparoscopic wedge resection was performed for definitive diagnosis.Pathologically,the tumor was shown to be gastric carcinoid infiltrating the muscle layer which indicated the probability of lymph node metastasis.Serum gastrin levels were normal.As a radical treatment,laparoscopy-assisted distal gastrectomy with regional lymphadenectomy was performed 3 wk after the initial surgery.Finally,pathological examination revealed no lymph node metastasis. | Takahiro Kinoshita Takashi Oshiro Tasuku Urita Yutaka Yoshida Mitsuru Ooshiro Shinichi Okazumi Ryoji Katoh Daisuke Sasai Nobuyuki Hiruta | 2010 | World Journal of Gastrointestinal Surgery2010,2,11: | 2 |
| 11 | Role for DNAmethylation in the control of cell type specific maspin ex-pression显示文摘 | Futscher BW Oshiro MM Wozniak RJ | 2002 | Nat Genet2002,31,2: | 1 |
| 12 | Epigenetic silencing of DSC3 is a common event in human breast cancer显示文摘 | Marc M Oshiro Christina J Kim Ryan J Wozniak | 2005 | Breast Cancer Res2005,7,5: | 1 |
| 13 | Comparison of laparos-copy- assisted and total laparoscopic Billroth-1 gastrectomy for gas-tric cancer: a report of short-term outcomes 显示文摘 | Kinoshita T Shibasaki H Oshiro T | 2011 | Surg Endosc2011,25,5: | 1 |
| 14 | Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects显示文摘 | Iseki K Oshiro S Tozawa M | 2001 | Hypertension Research2001,24,69: | 1 |
| 15 | Primary malignant melanoma of the esophagus arising from a melanotic lesion: Report of a case 显示文摘 | Takashi Oshiro Hideaki Shimoji | 2007 | Surg Today2007,37,: | 1 |
| 16 | Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho- kinase in vivo显示文摘 | Kawano Y Fukata Y Oshiro N | 1999 | J Cell Biol1999,147,5: | 1 |
| 17 | Scaling of structures subject to impact loads when using a power law constitu- tive equation显示文摘 | Oshiro R E Alves M | 2009 | Solids Struct2009,,4: | 1 |
| 18 | Contralateral approaches to bilateral cerebral aneurysms: a microsurgical anatomical study 显示文摘 | Oshiro EM Rini DA Tamargo RT | 1997 | J Neurosurg1997,87,2: | 1 |
| 19 | Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells显示文摘 | Catlett-Falcone R Landowski TH Oshiro MM | 1999 | Immunity1999,10,1: | 1 |
| 20 | Inhibition of experimental vasospasm in rats with the periadventitial administration of ibuprofen using controlled - release polymers显示文摘 | Thai QA Oshiro EM Tamargo RJ | 1999 | Stroke1999,30,1: | 1 |