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| 1 | Hepatitis B infection among adults in the philippines:A national seroprevalence study显示文摘AIM:To determine the prevalence of hepatitis B surface antigen(HBsAg)seropositivity among adult Filipinos.METHODS:Testing for HBsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey(NNHeS)conducted in 2003.Information on age,sex,marital status,educational attainment,employment status,and income were collected.For this study,marital status was classified as never married or otherwise(i.e.,married,divorced,separated,widowed);educational attainment was classified as high school graduate or below or at least some tertiary education;and employment status was classified as currently employed or currently unemployed.Annual income was divided into 4 quartiles in Philippine pesos(PhP):Q1,≤ PhP 53064;Q2,PhP 53065-92192;Q3,PhP 92193-173387;and Q4,≥ PhP 173388.Prevalence estimates were weighted so that they represented the general population.Social and demographic factors were correlated with HBsAg seropositivity.Multivariate analysis was used to determine independent predictors of HBsAg seropositivity.RESULTS:A total of 2150 randomly selected adults,20 years and over,out of the 4753 adult participants of NNHeS were tested for HBsAg.The HBsAg seroprevalence was 16.7%(95%CI:14.3%-19.1%),which corresponded to an estimated 7278968 persons infected with hepatitis B.There was no significant difference between males and females(17.5% vs 16.0%;P = 0.555).This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis B.The HBsAg seroprevalence peaked at age 20-39 years old,with declining prevalence in the older age groups.The only independent predictor of HBsAg seropositivity was the annual income,with persons in the highest income quartile being less likely to be HBsAg positive(age-adjusted OR = 0.51;95%CI:0.30-0.86)compared to subjects in the lowest income quartile.Sex,marital status,educational attainment,and employment status were not found to be independent predictors of HBsAg seropositivity.CONCLUSION:The high HBsAg seroprevalence among adults in the Philippines classifies the country as hyperendemic for HBV infection and appears unchanged over the last few decades. | Stephen N Wong Janus P Ong Madalinee Eternity D Labio Oscar T Cabahug Maria Lourdes O Daez Erlinda V Valdellon Jose D Sollano Jr Marilyn O Arguillas | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 2 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Nonlinear dynamics of heart rate variability in response to orthostatism and hemodialysis in chronic renal failure patients: Recurrence analysis approach显示文摘 | Hortensia González Oscar Infante Héctor Pérez-Grovas Marco V. Jose Claudia Lerma | 2012 | Medical Engineering and Physics2012，，： | 2 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 6 | New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities显示文摘 | Rodriguez Ⅱ Shi Y P Oscar J G | 2004 | J Nat Prod2004，67，： | 1 |
| 7 | Further flavonol glycosides from Anthyllis onobrychioides 显示文摘 | Oscar B Juan F S Juan S P | 1986 | Phytochemistry1986，25，11： | 1 |
| 8 | Measuring triggering interaction complexity on active database显示文摘 | Oscar D Mario P Coral C | 2001 | Information Systems2001，26，1： | 1 |
| 9 | Lactic acid bacteri- a:The bugs of the new millennium显示文摘 | Wil N Koning Jan Kok Oscar P Kuipers | 2000 | Current Opinion in Microbi- ology2000，3，3： | 1 |
| 10 | Secondary ettringite formation in concrete subjected to different curing conditions显示文摘 | OSCAR R B MILANESI A C MAIZA P J | 2000 | Cement and Concrete Research2000，30，9： | 1 |
| 11 | Plenary Lecture: innovative modeling approaches applicable to risk assessments显示文摘 | OSCAR T P | 2011 | Food Microbiology2011，28，4： | 1 |
| 12 | Lactic add bacteria: The bugs of the new millennium显示文摘 | Wiln K jan K Oscar P | 2000 | Current Opinion in Microbi ology2000，39，3： | 1 |
| 13 | Validation of lag time and growth rate models for Salmonella typhimurium: acceptable prediction zone method显示文摘 | OSCAR T P | 2005 | Journal of Food Science2005，70，2： | 1 |
| 14 | Invasive species can handle higher leaf temperature under water stress than Mediterranean natives显示文摘 | Oscar G Jose P L Fernando V | 2011 | Envi- ronmental and Experimental Botany2011，71，2： | 1 |
| 15 | Effect of fish predation on intertidal benthic fauna is modified by crab bioturbation显示文摘 | PAULINA M OSCAR I GABRIELA P | 2005 | Journal of Experimental Marine Biology and Ecology2005，318，1： | 1 |
| 16 | Obstetric antiphospholipid syndrome显示文摘 | Claudio Galarza-Maldonado Maria R. Kourilovitch Oscar M. Pérez-Fernández Mariana Gaybor Christian Cordero Sonia Cabrera Nikolai F. Soroka | 2011 | Autoimmunity Reviews2011，，4： | 1 |
| 17 | Development and validation of a tertiary simulation model for predicting the potential growth of Salmonella typhimurium on cooked chicken显示文摘 | OSCAR T P | 2002 | International Journal of Food Microbiology2002，76，3： | 1 |
| 18 | Development and validation of a stochastic model for predicting the growth of Salmonella typhimurium DT104 from a low initial density on chicken frankfurters with native microflora显示文摘 | OSCAR T P | 2008 | Journal of Food Protection2008，71，6： | 1 |
| 19 | Analysis of aerylamide in food products by in- line preconcentration capillary zone electrophoresis显示文摘 | Elisabet B Oscar N Luis P | 2006 | Journal of Chromatography A2006，1129，： | 1 |
| 20 | Predictive model for survival and growth of Salmonella typhimurium DT104 on chicken skin during temperature abuse显示文摘 | OSCAR T P | 2009 | Journal of Food Protection2009，72，2： | 1 |
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