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| 1 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 3 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 4 | Ant colony optimization in thinnedarray synthesis with minimum sidelobe level显示文摘 | OSCAR Q T EVA R I | 2006 | IEEE An-tennas Wireless Propagation Letters2006，，5： | 1 |
| 5 | A thinning algorithm for GPS-based unbiased FIR estimation of a clock TIE model显示文摘 | Yuriy S S Oscar I M Luis A M | 2008 | Measurement2008，41，： | 1 |
| 6 | Effect of fish predation on intertidal benthic fauna is modified by crab bioturbation显示文摘 | PAULINA M OSCAR I GABRIELA P | 2005 | Journal of Experimental Marine Biology and Ecology2005，318，1： | 1 |
| 7 | Auction design in day-ahead electricity markets显示文摘 | Javier C Oscar C Jose I F | 2001 | IEEE Transactions on Power Systems2001，16，1： | 1 |
| 8 | Development of anautonomous navigation system using a two -dimensional laser scannerin an orchard application显示文摘 | Oscar C J Akira M Kazunobu I | 2007 | Biosystem Engineering2007，96，2： | 1 |
| 9 | Nitrate removal in a riparian wetland of the Appalachian Valley and Ridge Physiographic Province 显示文摘 | OSCAR P ROBERT F I SHANNON D | 2002 | Journal of Environmental Quality2002，30，1： | 1 |
| 10 | Auction Design in Day-ahead Electricity Markets显示文摘 | Javier C Oscar C Jose I F | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 11 | Development of an autonomous navigation system using a two-dimensional laser scanner in an orchard application 显示文摘 | Oscar C J Akira M Kazunobu I | 2007 | Biosystem Engineering2007，96，2： | 1 |
| 12 | Resontlike phenomenon in short-pulse free-electron laser oscillators with modulated desynchronism显示文摘 | Oscar G Calderon Takuji Kimura Todd I Smith | 2001 | Phys Rev E2001，65，： | 1 |
| 13 | Residue determination of glyphosate,glufosinate and aminomethylphosphonic acid in water and soil samples by liquid chromatography coupled to electrospray tandem mass spectrometry显示文摘 | OSCAR P J JIJAN S V | 2005 | J Chromatogr A2005，1081，2： | 1 |
| 14 | Antimicrobial activity of polycationic peptides显示文摘 | Andrea G Oscar C Francosco I | 1999 | Peptides1999，20，： | 1 |
| 15 | A framework to analyze information systems as knowledge flow facilitators显示文摘 | OSCAR M RODRiGUEZ-ELIAS ANA I MARTINEZ-GARCUA AURORA VIZCAINO | 2008 | Information and Software Technology2008，50，6： | 1 |
| 16 | Recommendation System based on user interaction data applied to intelligent electronic books 显示文摘 | Rub 6 n C onz d lez Crespo Oscar Sanju d n Mart I nez Juan Manuel Cueva Lovelle etc | 2011 | Computers in Human Behavior2011，27，4： | 1 |
| 17 | MobiFree: a set of electronic mobility aids for the blind 显示文摘 | LOPES S I JOSE M N OSCAR F F | 2012 | Procedia Computer Science2012，，14： | 1 |
| 18 | Intrauterine shoulder weakness and obstetric brachial plexus palsy显示文摘 | Alfonso I Oscar Papazian O Shuhaiber H | 2004 | Pediatric Neurology2004，31，3： | 1 |
| 19 | Remova and immobilisation of cobalt ions by a novel hierarchically structured, diatomite/zeolite 5 composite显示文摘 | Oscar H R Patrick I H Desmond J | 2007 | Journal of Materials Chemistry2007，17，： | 1 |
| 20 | Oxidative stability of conventional and high-oleic vegetable oils with added antioxidants 显示文摘 | Merrill Lilon I Pike Oscar A Ogden Lynn V | 2008 | JAOCS2008，85，8： | 1 |
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