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| 1 | Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells显示文摘人的 pluripotent 干细胞(hPSC ) 导出 endothelial 系细胞组成有希望的来源因为在这个竞技场的治疗学的 revascularization,而是进步被临床上可伸缩的区别协议和在移植之上与宿主发行量集成的一个功能的容器网络的低效的形成的缺乏妨碍了。在绿的地方,使用一根人的胚胎的干细胞记者房间线荧光灯蛋白质表示被 endothelial 驾驶房间特定的 VE-cadherin (VEC ) 倡导者,我们为 > 屏蔽了;60 bioactive 将支持 endothelial 区别,并且发现 BMP4 和 GSK-3β 的那个政府的小分子;在有 VEGF 的一个早阶段和处理的禁止者 -- 在一个以后的阶段表明小径的槽口的 A 和抑制在六天以内导致了 hPSCs 的有效区别到 endothelial 系。这条顺序的途径产生了 >到 endothelial 房间(EC ) 的 hPSCs 的50%变换,明确地 VEC + CD31 + CD34 + CD14 − KDR 在 endothelial 系房间之中展出了更高的 angiogenic 和 clonogenic 增长潜力的高 endothelial 祖先( EP )。药品的抑制或基因槽口发信号击倒,在有 VEGF 的联合 -- 一个处理,经由 KDR + mesodermal 先锋和对成熟 EC 的 EP 的变换的封锁导致了 EP 的有效形成。当移植了进 immunocompromised 老鼠时,产生 EP 成功地与吻合在 vivo 形成了功能的毛状的容器到主人容器。在我们的协议表明电路的这 VEGF-A-Notch 的操作由 12- 导致导出 hPSC 的 EP 的快速的大规模生产到 20 褶层对当前的方法,它可以与与成熟 EC 相比形成能力的优异容器为再生 vascularization 用作一张吸引人的房间人口。 | Makoto Sahara Emil M Hansson Oliver Wemet Kathy O Lui Daniela Spater Kenneth R Chien | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 3 | Epidemiology of extended-spectrum beta-lactamase-producing Enterobacter isolates in a Spanish hospital during a 12-year period 显示文摘 | Canton R Oliver A Coque T M | 2002 | J Clin Microbiol2002，40，： | 3 |
| 4 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 5 | Compliance and results of treatment for amblyopia in children more than 8 years old显示文摘 | Oliver M Neumann R Chaimoviteh Y Gotesman N Shimshoni M | 1986 | Am J Ophthalmol1986，15，： | 1 |
| 6 | Modeling material failure in concrete structures under cyelie aetions显示文摘 | Faria R Oliver J Cervera M | 2004 | Journal of Structural Engineering2004，130，12： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | Measurement of flour color in color space parameters 显示文摘 | Oliver J R Blakeney A B Allen H M | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 9 | The impact of technology invest- ments on a firm's production efficiency, product quality, and pro- ductivity 显示文摘 | THATCHER M E OLIVER J R | 2001 | Journal of Management Information Systems2001，18，2： | 1 |
| 10 | Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells 显示文摘 | Khan S M Oliver R H Yeh J | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 11 | Investigation of mixing in a rotor shape modified Taylor-vortex reactor by the means of a chemical test reaction显示文摘 | Oliver R Markus M Bettina K C | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 12 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 13 | Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli显示文摘 | PUNT P J OLIVER R P DINGEMANSE M A | 1987 | Gene1987，56，1： | 1 |
| 14 | The SAPHO syndrome: a clinical and imaging study 显示文摘 | Salles M Olive A Perez - Andres R | 2011 | ClinRheumatol2011，30，2： | 1 |
| 15 | Absorption,distribution,metabolism,and excretion of ticagrelor in healthy subjects显示文摘 | TENG R OLIVER S HAYES M A | 2010 | Drug Metab Dispos2010，38，： | 1 |
| 16 | Outbreak of Cryptosporidium parvum among children after a school excursion to an adventure farm,south west England显示文摘 | Hoek M R Oliver l Barlow M | 2008 | Journal of water and health2008，6，3： | 1 |
| 17 | Connexin 31 (GJB3) is expressed in the peripheral and auditory nerves and causes neuropathy and hearing impairment显示文摘 | Lopez-Bigas N Olive M Rabionet R | 2001 | Hum Mol Genet2001，10，： | 1 |
| 18 | The colour of flour streams as related to ash and pigment contents 显示文摘 | Oliver J R Blakeney A B Allen H M | 1993 | Journal of Cereal Science1993，17，： | 1 |
| 19 | Critical flow velocities for the growth and dominance of Anabaena circinalis in some turbid freshwater rivers显示文摘 | MITROVIC S M OLIVER R L REES C | 2003 | Freshwater Biology2003，48，： | 1 |
| 20 | Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects显示文摘 | TENG R OLIVER S HAYES M A | 2010 | Drug Metab Dispos2010，38，9： | 1 |
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