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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Simple-sequence repeat markers used in merging linkage maps of melon ( Cucumis melo L.)显示文摘 | M. J. Gonzalo M. Oliver J. Garcia-Mas A. Monfort R. Dolcet-Sanjuan N. Katzir P. Arús A. J. Monforte | 2005 | Theoretical and Applied Genetics2005，，5： | 2 |
| 3 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 4 | Simple-sequence repeat markers used in merging linkage maps of melon (Cucumis melo L.)显示文摘 | M. J. Gonzalo M. Oliver J. Garcia-Mas A. Monfort R. Dolcet-Sanjuan N. Katzir P. Arús A. J. Monforte | 2005 | Theoretical and Applied Genetics2005，，5： | 2 |
| 5 | Strontium isotopes as trancers of ecosystem processes:theory and methods显示文摘 | Rosemary C C Brian W S Oliver A C | 1998 | Geoderma1998，82，： | 1 |
| 6 | 显示文摘 | Py X Olives R Mauran S | 2001 | International Journal of Heat and Mass Transfer2001，44，14： | 1 |
| 7 | Pharmacokinetics and tolerability of gemifloxacin (SB- 265805) after administration of single oral doses to healthy volunteers 显示文摘 | Allen A Bygate E Oliver S | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 8 | The relative effects of deformation and thermal advection on fluid pathways in basin-related mineralization显示文摘 | Mclellan J G Oliver N H S Hobbs B E | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 9 | Sildenafil for 'blue babies'显示文摘 | Oliver J Webb D Patole S | 2002 | BMJ2002，325，： | 1 |
| 10 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 11 | Extrahepatic metastases of hepatocellular carcinoma 显示文摘 | Katyal S Oliver J H Peterson M S | 2000 | Radiology2000，216，3： | 1 |
| 12 | 显示文摘 | OLIVER S G WINSON M K KELL D B | 1998 | Trends in Biotechnology1998，16，9： | 1 |
| 13 | Trunk muscle activity during bridging exercises on and off a Swiss ball 显示文摘 | Lehman GJ Hoda W Oliver S | 2005 | Chiropr Os- teopat2005，13，： | 1 |
| 14 | A geostatistical analysis of the spatial variation of soil mineral nitrogen and potentially available nitrogen within an arable field显示文摘 | Baxter S J Oliver M A Gaunt J | 2003 | Precision Agriculture2003，，4： | 1 |
| 15 | Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells 显示文摘 | Khan S M Oliver R H Yeh J | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
| 16 | Expression of indoleamine 2, 3- dioxygenase in tumor endothelial cells correlates with Long-term survival of patients with renal cell carcinoma 显示文摘 | Rainer R Christoph W Oliver S | 2007 | Clin Cancer Res2007，13，23： | 1 |
| 17 | Response Determi-nants in Satisfaction Judgments显示文摘 | DESARBO W S | 1998 | Journal of Con-sumer Research1998，14，3： | 1 |
| 18 | Testosterone:its role in development of prostate cancer and potential risk from use as hormone replacement therapy显示文摘 | Slater S Oliver RTD | 2000 | Drugs Aging2000，17，6： | 1 |
| 19 | An iterative ensemble Kalman filter for multiphase fluid flow data assimilation 显示文摘 | Gu Y Oliver D S | 2007 | SPE Journal2007，12，4： | 1 |
| 20 | Potential virulencefactors of Streptococcus dysgalactiae associated with bovinemastitis显示文摘 | Calvinho L F Almeida R A S P Oliver | 1998 | Vet Microbiol1998，61，： | 1 |
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