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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | A novel DNA virus (TTV) associated with elevated transaminase levels in post-transfusion hepatitis of unknown etiology显示文摘 | Nishizawa T Okamoto H Konishi K | | 0，，： | 3 |
| 3 | Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology显示文摘 | Okamoto H Nishizawa T Kato N | | 0，，： | 2 |
| 4 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 5 | Arrayed-waveguide grating multiplexer with flat spectral response显示文摘 | Okamoto K Yamada H | 1995 | Optics Lett1995，20，1： | 2 |
| 6 | Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N- acetylcysteine-treated in vivo model 显示文摘 | Urashima H Okamoto T Takeji Y | 2004 | Cornea2004，23，6： | 1 |
| 7 | Human lens epithelial cell line显示文摘 | Ibaraki N Chen SC Lin LR Okamoto H Pipas JM Reddy VN | 1998 | Exp Eye Res1998，67，5： | 1 |
| 8 | Typing hepatitis B virus by homology in nucleotide sequence:comparison of surface antigen subtype 显示文摘 | OKAMOTO H TSUDA F SAKUGAWA H | 1988 | Gen Virol1988，69，10： | 1 |
| 9 | Fe-Co-B/Ni-Fe soft magnetic underlayer with high-saturation magnetization for perpendicular magnetic recording media显示文摘 | Okamoto T Nakagawa S | 2003 | IEEE Trans Magn2003，39，5： | 1 |
| 10 | Hydrothermal synthesis of biocompatible whisker显示文摘 | Suda H Okamoto K | 1994 | J Mater Sci1994，29，13： | 1 |
| 11 | Genetic variability and evolution of hepatitis E virus显示文摘 | Okamoto H | 2007 | Virus Res2007，127，2： | 1 |
| 12 | FEN219, an auxin-regulated gene, difins a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development显示文摘 | Hsieh H L Okamoto H Wang M L | 2000 | Genes & Development2000，5，3： | 1 |
| 13 | Trichostatin A, an inhibitor of histone deacetylase,inhibits smooth muscle cell proliferation via induction of p21 (WAF1) 显示文摘 | Okamoto H Fujioka Y Takahashi A Takahashi T Taniguchi T Ishikawa Y | 2006 | J Atheroscler Thromb2006，13，： | 1 |
| 14 | Development of a novel Chemical - Looping Combustion:Synthesis of a looping material with a double metal oxide of CoO - NiO 显示文摘 | Jin H Okamoto T Ishida M | 1998 | Energy & Fuels1998，12，6： | 1 |
| 15 | Presence of antibodies to hepatitis Evirus in Japanese pet cats 显示文摘 | Okamoto H Takahashi M Nishizawa T | 2004 | Infection2004，32，1： | 1 |
| 16 | Flow cytometric analysis of proliferative activity of pleomorphic adenoma of salivary gland 显示文摘 | Okamoto H Tsuruta Y Miyahara H | 1998 | Nippon Jibiinkoka Gakkai Kaiho1998，101，6： | 1 |
| 17 | Use of early-phase dynamic spiral computed tomography for the primary screening of multiple trauma显示文摘 | Okamoto K Norio H kaneko N | 2002 | Am J Emerge Med2002，20，： | 1 |
| 18 | A novel DNA virus (TTV) associated with elevated transaminase levels in post transfusion hepatitis of unknown etiology显示文摘 | Nishizawa T Okamoto H Konishi K | 1997 | Biochem Biophys Res Commun1997，241，： | 1 |
| 19 | Plasmid-encoded metallo-beta-lactamase(IMP-6) conferring resistance to carbapenems, especially meropenem显示文摘 | Yano H Kuga A Okamoto R | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 20 | Naproxen partical design using porous starch显示文摘 | NAGATE K OKAMOTO H DAN JO K | 2001 | Drug Develop Indus Pharm2001，21，4： | 1 |
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