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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation 显示文摘 | Lamph W W Dwarki V J Ofir R | 1990 | Proc Natl Acad Sci USA1990，87，11： | 1 |
| 3 | PLA2G6 mutation underlies infantile neuroaxonal dystrophy显示文摘 | KhateebS Flusser H Ofir R | 2006 | Am J Hum Genet2006，79，5： | 1 |
| 4 | Inhibition of serotonin re-uptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S Vaya J | 2003 | J Mol Neurosci2003，20，2： | 1 |
| 5 | Inhibition of serotonin reuptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S | 2003 | J Mol Neurosei2003，20，2： | 1 |
| 6 | Measuring Images of Foreign Products显示文摘 | OFIR C LEHMANN D R | | 0，，02： | 1 |
| 7 | Taxol-induced apoptosis in human SKOV3 ovarian and MCF-7 breast cancer cells is Cas- pase-3 and Caspase-9 independent 显示文摘 | Ofir R Seidman R Rabinski T | 2002 | Cell Death Differ2002，9，6： | 1 |
| 8 | Ovine growth hormone gene duplication - structural and evolutionary implications 显示文摘 | OFIR R GOOTWINE E | 1997 | Mamm Genome1997，8，10： | 1 |
| 9 | A generalized method for HEN synthesis using stochastic optimization – I. General framework and MER optimal synthesis显示文摘 | Daniel R Lewin Hao Wang Ofir Shalev | 1998 | Computers and Chemical Engineering1998，，10： | 1 |
| 10 | Comparison of oral mucosal pH valuesin bulimia nervosa,GERD,BMS patients and healthy population显示文摘 | Aframian DJ Ofir M Benoliel R | 2010 | Oral Dis2010，16，8： | 1 |
| 11 | Taxol-induced ap- optosis in human SKOV3 ovarian and MCF 7 breast cancer cells is Caspase-3 and Caspase 9 independent显示文摘 | OFIR R SEIDMAN R RABINSKI T | 2002 | Cell Death Differ2002，9，6： | 1 |
| 12 | Cloning and characterization of the A6 polyunsaturated fatty acid elongase from the green microalga Parientochloris incisa显示文摘 | ISKANDAROV U KHOZIN-GOLDBERG I OFIR R | 2009 | Lipids2009，44，6： | 1 |
| 13 | Taxol-indtsced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent显示文摘 | OFIR R SEIDMAN R RABINSKI T | 2002 | Cell Death and Differentiation2002，9，6： | 1 |
| 14 | Ovine growth hormone gene duplicationstructural and evolutionary implications显示文摘 | Ofir R Goot wine E | 1997 | Mammalian G enome1997，8，10： | 1 |
| 15 | Comparison of oral mucosal pH values in bulimia nervosa,GERD,BMS patients and healthy population显示文摘 | Aframian D J Ofir M Benoliel R | 2010 | Oral Dis2010，16，： | 1 |
| 16 | Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ显示文摘 | Barel O Shorer Z Flusser H Ofir R Narkis G Finer G | 2008 | Am J Hum Genet2008，82，： | 1 |
| 17 | Comparison of oral mucosal pH values in bulimia nervosa,GERD,BMS patients and healthy popu- lation 显示文摘 | Aframian DJ Ofir M Benoliel R | 2010 | Oral Dis2010，16，8： | 1 |
| 18 | Inhibition of serotonin reuptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S | 2003 | J Mol Neurosci2003，20，2： | 1 |
| 19 | Inhibition of serotonin re-uptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S | 2003 | Journal Molecule Neuroscience2003，20，2： | 1 |
| 20 | Ovine growth hormone gene duplication -structural and evolutionary implications 显示文摘 | Ofir R Gootwine E | 1997 | Mammalian Genome1997，8，10： | 1 |
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