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| 1 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 2 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 3 | Mechanisms of cardiovas cular changes in an experimental model of syndrome X and pharmacological intervention on the renin-angiotensin-system显示文摘 | Montserrat C Norma R | 2004 | Current Vascular Pharmacology2004，2，： | 1 |
| 4 | A new rapid fluorogenic method for measuring bacteriocin activity显示文摘 | Norma de la Fuente-Salcido Salcedo-Hernandez R Ala- nis-Guzman MG | 2007 | Journal of Microbi- ological Methods2007，70，1： | 1 |
| 5 | Lifetstyle changes in women with polycystic ovary syndrome显示文摘 | Moran LJ Hutchison SK Norma R J | 2011 | Cochrane Database Syst Rev2011，7，00： | 1 |
| 6 | Quantifying Self-Report Measures’ Overestimation of Mobility Scores Postarthroplasty/Invited Commentary/Invited Commentary/Author Response显示文摘 | Stratford Paul W Kennedy Deborah M Maly Monica R MacIntyre Norma J Mizner Ryan L Pua Yong Hao Bennell Kim L | 2010 | Physical Therapy2010，，9： | 1 |
| 7 | Electrodeposited polyaniline in a nanoporous WO3 ma- trix: An organic/inorganic hybrid exhibiting both p- and n- type photoelectrochemical activity 显示文摘 | Csaba Jandky Norma R de Tacconi Wilaiwan Chanmanee | 2012 | J Phys Chem C2012，116，6： | 1 |
| 8 | Metabolic profiles of sunflower genotypes with contrasting response to Sclerotinia sclerotiorum infection显示文摘 | Peluffo L Lia V Troglia C Maringolo C Norma P Escande A Esteban Hopp H Lytovchenko A Fernie A R Heinz R Carrari F | 2010 | Phytochemistry2010，71，1： | 1 |
| 9 | Spect roelectrochemist ry of palladium hexaeyanoferrate films on platinum substrates 显示文摘 | REYNALDO O L ROBERTO R NORMA R D T | 2003 | Journal of Electroanalytical Chemistry2003，544，： | 1 |
| 10 | Species of agave with antimicrobial activity against selected pathogenic bacteria and fungi显示文摘 | ANGELES V S JULIA V SANTOS G NORMA H AZUCENA O CATALINA R | 2008 | World J Microbiol Biotcchnol2008，24，： | 1 |
| 11 | Creep and dynamic mechanical behavior of PP-jute composites: Effect of the interfacial adhesion显示文摘 | Betiana A A Maria M R Norma E M | 2007 | Composites: Part A Applied Science and Manufacturing2007，38，6： | 1 |
| 12 | RAPD and ISSR markers indicate diminished gene flow due to recent fragmentation of Polylepis australis woodlands in central Argendna显示文摘 | NORMA J ANA S JUAN R D JULIO D R DANIEL R ISABELL H | 2008 | Biockemical Systematics and Ecology2008，36，： | 1 |
| 13 | Improving reproductive performance in overweight/obese women with effective weight management显示文摘 | Norma RJ Noakes M Wu R | 2004 | Hum Reprod Update2004，20，3： | 1 |
| 14 | Acute heat stress effects on physiology and fear-related behaviour in red jungle fowl and domestic fowl 显示文摘 | Zulkifli I Dass R T Che Norma M T | 1999 | Canadian Journal of Animal Science1999，79，： | 1 |
| 15 | Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia : a prospective cohort study of air force veterans显示文摘 | Amit G Norma K Claus G R | 2006 | Environ Health Perspect2006，114，11： | 1 |
| 16 | Effects of enalapril on the vascular wall in an experimental model of syndrome显示文摘 | Norma R Susana G | 2002 | XAJH2002，15，： | 1 |
| 17 | Methods for determination of toxic organic compounds in air显示文摘 | William T W Norma T M Riggan R M | 2009 | NJ USA: Noyes Data Corporation2009，，： | 1 |
| 18 | Viruses and virus like particles detected during examination of feces from calves and piglets with diarrhea显示文摘 | Durham P J K Hassard L E Norma G R B | 1989 | Can Vet J1989，30，11： | 1 |
| 19 | Adsorption isotherm studies of chromium (VI) from aqueous solutions using sol-gel hydrotalcite-like compounds 显示文摘 | ESTHELA R R NORMA L GUTIERREZ O | 2009 | J Hazard Mater2009，172，： | 1 |
| 20 | Acute heat stress effects on physiology and fear-related behaviour inred jungle fowl and domestic fowl显示文摘 | ZULKIFLI I DASS R T NORMA M T | 1999 | Canadian Journal of Animal Science1999，79，： | 1 |
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