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| 1 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 2 | Liver support systems : will they ever reach prime time? 显示文摘 | Banares R Catalina MV Vaquero J | 2013 | Curr Gastroenterol Rep2013，15，3： | 1 |
| 3 | Car- diac dysfunction during liver transplantation incidence and preoperative predictors显示文摘 | RIPOLL C CATALINA M V YOTT I R | 2008 | Transplantation2008，85，： | 1 |
| 4 | Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells显示文摘 | CATALINA M D SULLIVAN J L BRODY R M | 2002 | J Immunol2002，168，8： | 1 |
| 5 | Determination of chlorphenoxy acid herbicides in water by in situ esterification followed by invial liquid-liquid extraction combined chromatography-mass spectrometry显示文摘 | M I Catalina J Dalluge R J J Vreuls | 2000 | Journal of Chromatography2000，887，： | 1 |
| 6 | A review of stir bar sorptive extraction显示文摘 | Fuensanta S R Catalina B O JoséM C P | 2009 | Chromatographia2009，69，12： | 1 |
| 7 | Surgical outcomes and seizure control rates after resection of dysembryoplastic neuroepithelial tumors显示文摘 | David I S John R Catalina D | 2005 | Neurosurg2005，6，： | 1 |
| 8 | Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties? 显示文摘 | Catalina P Montes R Ligero G | 2008 | Mol Cancer2008，7，： | 1 |
| 9 | Liver support systems:will they ever reach prime time显示文摘 | BAARES R CATALINA M V VAQUERO J | | 0，，03： | 1 |
| 10 | Antioxidant and antimicrebial activities of rosemary extracts linked to their polyphenol composition 显示文摘 | Silvia M Tamara S Catalina S R | 2006 | Free Radical Research2006，40，2： | 1 |
| 11 | Species of agave with antimicrobial activity against selected pathogenic bacteria and fungi显示文摘 | ANGELES V S JULIA V SANTOS G NORMA H AZUCENA O CATALINA R | 2008 | World J Microbiol Biotcchnol2008，24，： | 1 |
| 12 | Changes in polyamine content are related to low temperature resistance in potato plants显示文摘 | Manricio HM Jesus NR Catalina R 1999 | 1999 | Acta Biologica Colombiana1999，4，： | 1 |
| 13 | The markers of inflammation and endothelial dysfunction in correlation with glycated hemoglobin are present in type 2 diabetes mellitus patients but not in their relatives显示文摘 | GOMEZ JM VILA R CATALINA P | 2008 | Glycoconj J2008，25，6： | 1 |
| 14 | 1,2,4,5- Benzcnetetracarboxylic acid and 4,4'-bipyridine as lig- ands in dcsining low-dimensional coordination polymers 显示文摘 | Catalina R P Pablo L L Maria H M | 2004 | Eur J Inorg Chem2004，，： | 1 |
| 15 | Total phenolic compounds and antioxidant capacities of major fruits from Ecuador显示文摘 | Catalina V Jenny R Afaf K E | 2008 | Food Chemistry2008，111，4： | 1 |
| 16 | Mechanisms of regulation of G protein-coupled receptor kinases(GRKs)and cardiovascular disease显示文摘 | Petronila P Cristina M Catalina R | | 0，，01： | 1 |
| 17 | Mechanisms of regulation of G protein-coupled receptor kinases (GRKs)and cardiovascular disease显示文摘 | Petronila P Cristina M Catalina R | | 0，，： | 1 |
| 18 | Neonatal cholestasis and hepatosplenomegaly caused by congenital dyserythropoietic anemia type 1: A case report显示文摘BACKGROUND Congenital dyserythropoietic anemia type 1(CDA1)is an autosomal recessive disorder of ineffective erythropoiesis,resulting in increased iron storage.CDA1 is usually diagnosed in children and adolescents but can rarely present in the neonatal period with severe anemia at birth.There are no prior reports of neonatal liver histologic findings of CDA1.We report a case of CDA1 in a newborn presenting with severe anemia,cholestasis and liver failure,where liver biopsy helped confirm the diagnosis.CASE SUMMARY A term infant,born via emergency Cesarean section,presented with cholestasis,hepatosplenomegaly,multiorgan failure and severe anemia at birth.A prior pregnancy was significant for fetal demise at 35 wk without autopsy or known etiology for the fetal demise.Parents are both healthy and there is no history of consanguinity.On further evaluation,the patient was found to have severe ferritin elevation and pulmonary hypertension.An extensive infectious and metabolic work-up was negative.Salivary gland biopsy was negative for iron deposition.At 2 wk of age,a liver biopsy showed findings consistent with CDA1.A genome rapid sequencing panel revealed novel variants in the CDAN1 gene.The patient’s liver dysfunction,cholestasis and organomegaly resolved,however she remains transfusion-dependent.CONCLUSION We report liver pathology findings of CDA1 with a novel genetic mutation for the first time in a newborn. | Catalina Jaramillo Anna K Ermarth Angelica R Putnam Mark Deneau | 2019 | World Journal of Hepatology2019，11，5： | 1 |
| 19 | Cardiac dysfunction during liver transplantation: incidence and preoperative predictors显示文摘 | Ripoll C Catalina MV Yotti R | 2008 | Transplantation2008，85，： | 1 |
| 20 | Acute on chronic liver failure:A new concept for a classic complication显示文摘 | Catalina M V Ibanez L Banares R | 2014 | Gastroenterol Hepatol2014，37，22： | 1 |
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