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| 1 | 水通道蛋白对人体皮肤重要性的研究显示文摘目的探讨水通道蛋白(AQPs)在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30~40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21~60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中,AQP3从基底层到粒层均有表达,但在角质层下方开始消失,AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20~80岁之间的健康女性皮肤间接免疫荧光研究也发现,在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关,水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。 | Frédéric Bonté Emmanuelle Noblesse Miléne Juan Jean Marc Verbawatz Marc Dumas | 2009 | 中华皮肤科杂志2009，42，5： | 4 |
| 2 | Practical evaluation of the drag of a ship for design and optimization显示文摘We consider two major components of the drag of a ship,the'friction drag'and the'wave drag',that are related to viscous friction at the hull surface and wavemaking,and mostly depend on the Reynolds number and the Froude number,respectively.We also consider the influence of sinkage and trim,viscosity,and nonlinearities on the drag.The sum of the friction drag given by the classical ITTC friction formula and the wave drag predicted by the modification,called Neumann-Michell(NM)theory,of the classical Neumann-Kelvin theory of ship waves is found to be within about 10%of experimental drag measurements for four ship hulls for which theoretical predictions and experimental measurements are compared.The sum of the ITTC friction drag and the NM wave drag can then be expected to yield realistic practical estimates that can be useful for routine applications to design and hullform optimization of a broad range of displacement ships.Furthermore,we note several simple extensions of this highly simplified approach that can be expected to significantly improve accuracy. | YANG Chi HUANG Fuxin NOBLESSE Francis | 2013 | Journal of Hydrodynamics2013，25，5： | 4 |
| 3 | RANSE-based simulation and analysis of scale effects on open-water performance of the PPTC-II benchmark propeller显示文摘This paper presents our numerical study of the scale effects on a tip-rake propeller,the PPTC-II,based on the RANS simulations using software FLUENT 6.3.The low Re option in SST k-ωmodel is adopted at model scale,together with fine prism grids to resolve the viscous sub-layer.At full scale,standard wall function is adopted.The scale-effect corrections yielded by our RANS simulations are compared with those obtained from the ITTC method.To explain the CFD results,an analysis of sectional forces is performed.To investigate how the tip rake influences propeller scale effects,the geometry of PPTC-II is modified by removing the tip rake only,and the RANS-predicted scale effects for the modified propeller,PPTC-II-m,are compared with those for the PPTC-II.The study indicates that the scale effect on propeller thrust can be as important as that on the torque;somehow the RANS-and ITTC-based predictions for full-scale efficiency agree quite well;the tip-rake reduces tip loading and tip vortex strength,and brings about large differences in the scale effects as compared with the propeller without tip-rake. | Xiao-Qian Dong Wei Li Chen-Jun Yang Francis Noblesse | 2018 | Journal of Ocean Engineering and Science2018，3，3： | 3 |
| 4 | Effects of Blade Loading Distribution on the Cavitation and Excitation Forces of a Tunnel Thruster显示文摘Compared with open propellers, the impeller of a tunnel thruster is more vulnerable to cavitation and structural vibration problems because the impeller is typically subject to severe non-uniformity of inflow produced by the blunt gearbox. Model tests and numerical simulations are carried out in the cavitation tunnel of Shanghai Jiao Tong University for a tunnel thruster using a 'flat plate' impeller and a tip-unloaded one. The characteristics of fluctuating pressures on the tunnel wall and the resultant excitation forces are investigated. It is found that although unloading the blade tips of an impeller is effective in reducing the fluctuating pressures in a local tunnel wall area near the tips, the same trend does not apply to the case of the excitation forces. The results show that care should be taken when the experimentally measured fluctuating pressures are utilized as the input to the analysis of structural vibrations. | 郁程 董小倩 杨晨俊 李巍 NOBLESSE Francis | 2019 | Journal of Shanghai Jiaotong university(Science)2019，24，2： | 2 |
| 5 | Ship bow waves显示文摘The bow wave generated by a ship hull that advances at constant speed in calm water is considered. The bow wave only depends on the shape of the ship bow (not on the hull geometry aft of the bow wave). This basic property makes it possible to determine the bow waves generated by a canonical family of ship bows defined in terms of relatively few parameters. Fast ships with fine bows generate overturning bow waves that consist of detached thin sheets of water, which are mostly steady until they hit the main free surface and undergo turbulent breaking up and diffusion. However, slow ships with blunt bows create highly unsteady and turbulent breaking bow waves. These two alternative flow regimes are due to a nonlinear constraint related to the Bernoulli relation at the free surface. Recent results about the overturning and breaking bow wave regimes, and the boundary that divides these two basic flow regimes, are reviewed. Questions and conjectures about the energy of breaking ship bow waves, and free-surface effects on flow circulation, are also noted. | NOBLESSE Francis DELHOMMEAU Gerard LIU Hua WAN De-cheng YANG Chi | 2013 | Journal of Hydrodynamics2013，25，4： | 2 |
| 6 | The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model显示文摘 | Bouez C Rcynaud C Noblesse E | 2006 | Clinical Cancer Research2006，12，： | 1 |
| 7 | Practical hydrodynamic optimization of a monohull显示文摘 | D Hendrix S Percival F Noblesse | 2001 | SNAME Transactions2001，109，： | 1 |
| 8 | A slender-ship theory of wave resistance 显示文摘 | Noblesse F | 1987 | Journal of Ship Research1987，27，： | 1 |
| 9 | Neurostimulatory and ablative treatment options in major depressive disorder:a systematic review显示文摘 | Andrade P Noblesse LH Temel Y | 2010 | Acta Neurochir(Wien)2010，152，4： | 1 |
| 10 | Observations and computations of narrow Kelvin ship wakes显示文摘Computations of far-field ship waves,based on linear potential flow theory and the Hogner approximation,are reported for monohull ships and catamarans.Specifically,far-field ship waves are computed for six monohull ships at four Froude numbers F≡V/√gL=0.58,0.68,0.86,1.58 and for six catamarans with nondimensional hull spacing s≡S/L=0.25 at two Froude numbers F s≡V/√gS=1 and 2.5.Here,g is the gravitational acceleration,V and L denote the ship speed and length,and S is the separation distance between the twin hulls of a catamaran.The computations show that,although the amplitudes of the waves created by a ship are strongly influenced by the shape of the ship hull,as well known,the ray angles where the largest waves are found are only weakly influenced by the hull shape and indeed are mostly a kinematic feature of the flow around a ship hull.An important practical consequence of this flow feature is that the apparent wake angle of general monohull ships or catamarans(with arbitrarily-shaped hulls)can be estimated,without computations,by means of simple analytical relations;these relations,obtained elsewhere via parametric computations,are given here.Moreover,the influence of the two parameters F s and s that largely determine the ray angles of the dominant waves created by a catamaran is illustrated via computations for three catamarans with hull spacings s=0.2,0.35,0.5 at four Froude numbers F s=1,1.5,2,2.5.These computations confirm that the largest waves created by wide and/or fast catamarans are found at ray angles that only depend on F s(i.e.that do not depend on the hull spacing s)in agreement with an elementary analysis of lateral interference between the dominant waves created by the bows(or sterns)of the twin hulls of a catamaran.The dominant-waves ray angles predicted by the theory of wave-interference effects for monohull ships and catamarans are also compared with the observations of narrow Kelvin ship wakes reported by Rabaud and Moisy,and found to be consistent with these observations. | Francis Noblesse Chenliang Zhang Jiayi He Yi Zhu Chenjun Yang Wei Li | 2016 | Journal of Ocean Engineering and Science2016，1，1： | 1 |
| 11 | Hydrodynamic optimization of ship hull forms显示文摘 | Percival S Hendrix D Noblesse F | 2001 | Applied Ocean Research2001，23，： | 1 |
| 12 | Integral identities of potential theory of ladiation and diffraction of regular wave by a body 显示文摘 | Noblesse F | 1983 | Journal of Engineering Mathematics1983，17，1： | 1 |
| 13 | The fundamental solution in thetheory of steady motion of a ship 显示文摘 | NOBLESSE F | 1977 | Journal ofShip Research1977，21，2： | 1 |
| 14 | Comparison between theoretical predictions of wave resistance and experimental data for the Wigley hull显示文摘 | Chen C Y Noblesse F | 1983 | Journal of Ship Research1983，27，4： | 1 |
| 15 | A slender-ship theory of wave resistance显示文摘 | Noblesse F | 1983 | J of Ship Research1983，27，1： | 1 |
| 16 | Numerical evaluation of the green function of water-wave radition and diffraction 显示文摘 | TELSTE J G NOBLESSE F N | 1986 | Joural of Ship Research1986，30，2： | 1 |
| 17 | The Green function in the theory of radiation and diffraction of regular waves by a body显示文摘 | Noblesse F | 1982 | J Engg Math1982，16，： | 1 |
| 18 | A slender ship theory of wave resistance显示文摘 | | | JSR0，1983，： | 1 |
| 19 | Neurostimulatory and ablative treatment options in major depressive disorder: a systematic review显示文摘 | Pablo Andrade Lieke H. M. Noblesse Yasin Temel Linda Ackermans Lee W. Lim Harry W. M. Steinbusch Veerle Visser-Vandewalle | 2010 | Acta Neurochirurgica2010，，4： | 1 |
| 20 | Explicit approximations for calculating potential flow about a body显示文摘 | Triantafyllou G | 1983 | JSR1983，27，1： | 1 |
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