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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 5 | Proteomic anal- ysis of the cambial region in juvenile Eucalyptus grandis at three ages 显示文摘 | Celedon P A F de Andrade A Meireles K G X | 2007 | Proteomics2007，7，13： | 1 |
| 6 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 7 | Natural occurrence of abscisic acid in heather honey and floral nectar显示文摘 | Ferreres F Andrade P Franeisco A | 1996 | J Agric FoodChem1996，44，： | 1 |
| 8 | Piezoresistive properties of nanocrystalline silicon thin films deposited on plastic substrates by hot-wire chemical vapor deposition显示文摘 | ALPUIM P ANDRADE M SENCADAS V | | 0，，515： | 1 |
| 9 | Preliminary study offlavonols in port wine grape varieties 显示文摘 | ANDRADE P B MENDES G FALCO V | 2001 | Food Chem2001，73，4： | 1 |
| 10 | Full-face carbon dioxide laser resurfacing: a 10-year follow-up descriptive study 显示文摘 | Prado A Andrades P Danilla S | 2008 | Plast Reeonstr Surg2008，121，3： | 1 |
| 11 | The life cycle of Hebella furax (Cnidaria, Hydrozoa) :a link between a lafoeid hydroid and a laodiceid medusa显示文摘 | Migotto A E De Andrade L P | 2000 | J Nat Hist2000，34，： | 1 |
| 12 | Arbutin-2'-sulphonyl from the infusion of llex theezans leaves 显示文摘 | ANDRADE F D P PIACENTE S PIZZA C | 2004 | Fitoterapia2004，，78： | 1 |
| 13 | Diagnosis and treatment of prostatic abscess显示文摘 | Oliveira P Andrade J A Porto H C | 2003 | Int Braz J Urol2003，29，1： | 1 |
| 14 | Influence of morphology on in vitro compatibility of bioactive glasses显示文摘 | ANDRADE A VALERIO P GOES A M | 2006 | J Non-Cryst Solids2006，352，： | 1 |
| 15 | Synthesis of aNiFe204 catalyst for the preferential oxidation of carbon monoxide (PROX)显示文摘 | SANTOS P T A COSTA A C F M KIMINAMI R H G A ANDRADE H M C LIRA H L GAMA L | 2009 | Journal of Alloy and Compounds2009，483，12： | 1 |
| 16 | Efficacy and safety of cryoballoon ablation for atrial fibrillation:a systematic review of published studies显示文摘 | Andrade JG Khairy P Guerra PG | 2011 | Heart Rhythm2011，8，9： | 1 |
| 17 | A computationalmethod for recording and analysis of mandibular movements显示文摘 | Pinheiro A P Andrade A O Pereira A A | 2008 | Journal of Applied Oral Science2008，16，5： | 1 |
| 18 | Pesticide desorption from soils facilitated by dissolved organic matter coming from composts: ex- perimental data and modelling approach显示文摘 | Barriuso E Andrades M S Benoit P | 2011 | Biogeochemistry2011，106，： | 1 |
| 19 | A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a NO domain found in outer membrane transport proteins 显示文摘 | Souza D P Andrade M O Alvarez-Martinez C E | 2011 | PLoS Pathogens2011，7，10： | 1 |
| 20 | Caracterizacao morfol6 gica de acessos do ge nero Stylosanthes no banco ativo de germoplasma da Embrapa Cerrados-colecao 1994/1995 显示文摘 | Karia C T de Andrade R P Charchar M J D | 2002 | Embrapa Cerrados Boletim de Pesquisa e Desenvolvimento2002，72，： | 1 |
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