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| 1 | Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia显示文摘 | Catherine D Nobes Alan Hall | 1995 | Cell1995，，1： | 3 |
| 2 | Effects of Kampo medicine, Keishi-ka Shakuyaku-to (TJ-60) on alteration of diacylglycerol metabolism in gastrointestinal smooth muscle of diabetic rats显示文摘AIM:To examine the effects of Kampo medicine,Keishi-ka-Shakuyaku-to(TJ-60) on the signal transduction in diabetic gastrointestinal dysfunction.METHODS:Experimental diabetic models were prepared using streptozotocin (STZ)-treated Wistar rats.Randomly selected STZ rats were treated with insulin (12U·kg^-1·d^-1) or TJ-60(1% of food intake).Diacylglycerol(DG) and DG kinase activities were quantified in isolated aortic smooth muscle tissue.RESULTS:One of the key element of the PI-turnover,DG kinase activity in resting state in gastric smooth muscle was significantly increased compared to the control value,and carbachol (CCh)-induced response was not detectable,but it was detected in the control rats.On the other hand resting activity in ileum did not differ from the control,but the CCh-induced responses were suppressed.Treatment with TJ-60 indicated resistant effects for the alteration of DG kinase activities in diabetic intestinal tissues.In order to reveal the mechanism of the effects,total content of DG was measured,because the DG plays important role in the PI-turnover and the DG converted from not only PI but also incorporated glucose under high glucose condition.Patterns of the change in DG levels were similar to those in DG kinase.These results indicate that the effect of TJ-60 occurs at the cellular level of DG.CONCLUSION:Dysfunction of gastrointestinal smooth muscle in diabetes in mediated by an alternation of DG and DG kinase.TJ-60 influences the alteration and relief the dysfunction. | NOBE Koji MOMOSE Kazutaka SAKAI Yasushi | 2002 | Acta Pharmacologica Sinica2002，23，12： | 3 |
| 3 | 白内障摘除术后的急性眼内炎文献的系统回顾显示文摘目的:确定白内障摘除术后随时间推移报道的急性眼内炎的发生率并探讨可能引起的因素,如白内障手术切口类型。
方法:以白内障摘除术、眼内炎及术后并发症为关键词,对1963—2003年PubMed上的英文文献进行广泛检索。并进行系统性回顾。附加的研究确认为与其相切题的文献和已发表的会议记录。在可能提供的情况下。记录手术方式。对用不同手术切口技术导致眼内炎发展的累计发生率和相关危险度进行评估。用不同切口的技术评估累计眼内炎的发生率与发展眼内炎的相对危险因素。
结果:从4916篇特定且具潜在相关性的引文中对其中215篇涉及眼内炎且符合入选标准的研究进行分析。总共3140650例白内障手术后,累计0.128%发生眼内炎。然而,急性眼内炎的发生率随着时代不同而改变。与过去lO年相比。2000年以来发生率明显升高(相对危险度,2.44;95%可信区间,2.27—2.61)。2000—2003年眼内炎发生率为0.265%。20世纪90年代为0.087%,80年代为0.158%,70年代为0.327%。并且,与1991年及以前相比,1992年以来发生率有上升趋势。手术切口类型似乎是产生显著影响的危险因素,因为1992—2003年中,经透明角膜切口白内障手术后眼内炎发生率为0.189%。与经巩膜切口0.074%(相对危险度,2.55;95%可信区间,1.75—3.71)及经角巩膜缘切口0.062%(相对危险度,3.06;95%可信区间,2.48—3.76)的发生率相比较,手术切口类型似乎是产生显著影响的危险因素。
结论:这一系统回顾显示,与白内障摘除术相关眼内炎的发生率在过去10年中有所上升。其发生频率的上升趋势与当前无缝线透明角膜白内障摘除术的进展相一致。 | Mehran Taban Ashley Behrens Robert L. Newcomb Matthew Y. Nobe Golnaz Saedi Paula M. Sweet Peter J. McDonnell 胡妙妙(译) 蒋幼芹(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，1： | 2 |
| 4 | Mixing characteristics of axisymmetric free jets from a contoured nozzle, an orifice plate and a pipe显示文摘 | Mi J Nathan G J Nobes D S | 2001 | Transactions of the ASME2001，123，： | 1 |
| 5 | Electrodissolution kinetics of copper in acidic chloride solutions显示文摘 | BRAUN M NOBE K | 1979 | J Electro Chem Soc1979，126，3： | 1 |
| 6 | Gender differences in various types of idiopathic ventricular tachycardia显示文摘 | Nakagawa M Takahashi N Nobe S | 2002 | J Cardiovasc Electrophysiol2002，13，： | 1 |
| 7 | Oxidative reactions of phenol and chlorobenzene with in situ electro generated Fenton's reagent显示文摘 | Hsiao Y Nobe K | 1993 | Chem Eng Common1993，126，1： | 1 |
| 8 | Catalytic reduction of SO2 with CO on cobalt oxides显示文摘 | Bazes J G Caretto L S Nobe K | 1975 | Ind Eng Chem Prod Res Dev1975，14，4： | 1 |
| 9 | Starch, Fiber and CaCO3 Effects on the Physical Properties of Foams Made by a Baking Process显示文摘 | Gleen G M Orts W J Nobes G A R | 2001 | Industrial Crops and Products2001，14，3： | 1 |
| 10 | Electronic structure, properties and phase stability of inorganic crystals: A pseudopotential plane-wave study显示文摘 | MILMAN V WINKLER B WHITE J A PICKARD C J PAYNE M C AKHMATSKAYA E V NOBES R H | 2000 | International Journal of Quantum Chemistry2000，77，5： | 1 |
| 11 | Electrodeposited iron group thinfilm alloys : structure-property relationships 显示文摘 | MYUNG N V NOBE K | 2001 | J Electrochem Soc2001，148，13： | 1 |
| 12 | Observations on measuring the differences between domestic accounting standards and IAS 显示文摘 | Nobes C | 2009 | Journal of Accounting and Public Policy2009，28，： | 1 |
| 13 | Electrodeposited iron group thin-film alloys structure property relationship显示文摘 | Myung N V Nobe K | 2001 | J Electrochemical Society2001，148，3： | 1 |
| 14 | A study of the geoelectrical properties of peatlands and their influence onground-penetrating radar surveying显示文摘 | Theimer B D Nobes D C Warner B G | 1994 | Geophys Prospect1994，42，： | 1 |
| 15 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia显示文摘 | Nobes CD Hall A | 1995 | Cell1995，81，： | 1 |
| 16 | Activation of the GTP-binding protein Gq by rhodopsin in squid photoreceptor显示文摘 | NOBES C BAVERSTOCK J SAIBIL H | 1992 | Biochemical Journal1992，287，： | 1 |
| 17 | Thrombin-induced force development in vascular endothelial cells: contribution to alteration of permeability mediated by calcium-dependent and -independent pathways 显示文摘 | Nobe K Sone T Paul R J | 2005 | J Pharmacol Sci2005，99，3： | 1 |
| 18 | Numerical analyses of breaking waves using the Moving Particle Semi-implicit Method 显示文摘 | Koshizuka S Nobe A Oka Y | 1998 | Int J Numer Meth Fluids1998，26，： | 1 |
| 19 | Rho GTPases molecular switches that control the organization and dynamics of the actin cytoskeleton显示文摘 | Hall A Nobes CD | 2000 | Philos Trans Royal Soc Lond B Biol Sci2000，355，： | 1 |
| 20 | High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development显示文摘 | Nobe K Miyatake M Sone T | 2006 | Pharmacol Exp Ther2006，318，2： | 1 |
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