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| 1 | Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis显示文摘OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone metastasis.METHODS: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy.RESULTS: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group.CONCLUSION: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction. | Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 6 |
| 2 | Adsorption Performance of Sliding Wall-Climbing Robot显示文摘Sliding wall-climbing robot(SWCR) is applied worldwide for its continuous motion,however,considerable air leakage causes two problems:great power consumption and big noise,and they constraint the robot's comprehensive performance.So far,effective theoretical model is still lacked to solve the problems.The concept of SWCR's adsorption performance is presented,and the techniques of improving utilization rate of given adsorption force and utilization rate of power are studied respectively to improve SWCR's adsorption performance.The effect of locomotion mechanism selection and seal's pressure allocation upon utilization rate of given adsorption force is discussed,and the theoretical way for relevant parameters optimization are provided.The directions for improving utilization rate of power are pointed out based on the detail analysis results of suction system's thermodynamics and hydrodynamics.On this condition,a design method for SWCR-specific impeller is presented,which shows how the impeller's key parameters impact its aerodynamic performance with the aid of computational fluid dynamics(CFD) simulations.The robot prototype,BIT Climber,is developed,and its functions such as mobility,adaptability on wall surface,payload,obstacle ability and wall surface inspection are tested.Through the experiments for the adhesion performance of the robot adsorption system on the normal wall surface,at the impeller's rated rotating speed,the total adsorption force can reach 237.2 N,the average effective negative pressure is 3.02 kPa and the design error is 3.8% only,which indicates a high efficiency.Furthermore,it is found that the robot suction system's static pressure efficiency reaches 84% and utilization rate of adsorption force 81% by the experiment.This thermodynamics model and SWCR-specific impeller design method can effectively improve SWCR's adsorption performance and expand this robot applicability on the various walls.A sliding wall-climbing robot with high adhesion efficiency is developed,and this robot has the features of light body in weight,small size in structure and good capability in payload. | LI Jun GAO Xueshan FAN Ningjun LI Kejie JIANG Zhihong JIANG Zhijian | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 4 |
| 3 | Expression and actions of HIFprolyl-4-hydroxylase in the rat kidneys 显示文摘 | Ningjun LI Fan YI Christina M | 2007 | Am J Physiol Renal Physi-ol2007，292，： | 1 |
| 4 | Effects of homocysteine on intracell-ular nitric oxide and superoxide levels in the renal arterial endothelium显示文摘 | Ningjun Li Fuxian Yi Elizabeth Rute | 2002 | Am J Physiol Heart Circ Physiol2002，283，3： | 1 |
| 5 | Aquafeed fermentation improves dietary nutritional quality and benefits feeding behavior,meat flavor,and intestinal microbiota of Chinese mitten crab(Eriocheir sinensis)显示文摘Normally,proper fermentation can be an efficient and widely used method to improve feed quality in animal rearing;however,the studies on crustaceans,especially Eriocheir sinensis,remain limited.This study aimed to investigate whether feed fermentation could meliorate dietary nutritional value and benefit E.sinensis rearing.First,non-fermented feed(NFD)and fermented feed(FD)were produced and assessed,respectively.Then,the“Y”maze feed choice behavior test(180 times;30 times,6 rounds)was conducted to assess the attractiveness of these 2 feeds for crabs.Finally,a total of 80 crabs(44.10±0.80 g)were randomly assigned into 2 groups with 4 replicates,and fed the experimental diets for 8 weeks to evaluate the effects of each feed on growth,antioxidant capacity,meat flavor,and intestinal microbiota.In this study,FD showed higher levels of crude protein(P<0.01),soluble protein(P<0.01),amino acids(P<0.05),lactic acid(P<0.001),and lower levels of crude fiber(P<0.05)and antinutritional factors(agglutinin,trypsin inhibitor,glycinin,andβ-conglycinin)(P<0.001)than NFD.Additionally,FD was more attractive to crabs than NFD(P<0.01)and it stimulated the appetite of crabs more than NFD(P<0.05).The growth performance,feed efficiency,and digestive enzyme activity of FDfed crabs were significantly higher than those of NFD-fed crabs(P<0.05).The electronic sensory measurements and free amino acid profiles revealed that the FD diet had positive impacts on the meat flavor of crabs,particularly in“sweet”and“umami”tastes.Moreover,the antioxidant capacity of FD-fed crabs was significantly higher than that of NFD-fed crabs(P<0.05).Fermented feed also affected the diversity and composition of intestinal microflora.The functional prediction of microbial communities showed that crabs fed FD had a better microecological environment in the intestine.In conclusion,the fermentation of aquafeed could be an effective approach to enhance feed quality and therefore benefit E.sinensis rearing. | Weibo Jiang Xiaoyan Jia Ningjun Xie Chuang Wen Shuo Ma Guangzhen Jiang Xiangfei Li Cheng Chi Dingdong Zhang Wenbin Liu | 2023 | Animal Nutrition2023，，3： | 0 |
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