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| 1 | Low-radiation and high image quality coronary computed tomography angiography in “real-world” unselected patients显示文摘AIM To determine the radiation dose and image quality in coronary computed tomography angiography(CCTA)using state-of-the-art dose reduction methods in unselected'real world'patients.METHODS In this single-centre study,consecutive patients in sinus rhythm underwent CCTA for suspected coronary artery disease(CAD)using a 320-row detector CT scanner.All patients underwent the standard CT acquisition protocol at our institute(Morriston Hospital)a combination of dose saving advances including prospective electrocardiogram-gating,automated tube current modulation,tube voltage reduction,heart rate reduction,and the most recent novel adaptive iterative dose reconstruction 3D(AIDR3D)algorithm.The cohort comprised real-world patients for routine CCTA who were not selected on age,body mass index,or heart rate.Subjective image quality was graded on a 4-point scale(4=excellent,1=non-diagnostic).RESULTS A total of 543 patients were included in the study with a mean body weight of 81±18 kg and a pre-scan mean heart rate of 70±11 beats per minute(bpm).When indicated,patients received rate-limiting medication with an oral beta-blocker followed by additional intravenous beta-blocker to achieve a heart rate below 65 bpm.The median effective radiation dose was 0.88 mSv(IQR,0.6-1.4 mSv)derived from a Dose Length Product of61.45 mGy.cm(IQR,42.86-100.00 mGy.cm).This also includes what we believe to be the lowest ever-reported radiation dose for a routine clinical CCTA(0.18 mSv).The mean image quality(SD)was 3.65±0.61,with a subjective image quality score of 3('good')or above for 93%of patient CCTAs.CONCLUSION Combining a low-dose scan protocol and AIDR3D with a 320-detector row CT scanner can provide high quality images at exceptionally low radiation dose in unselected patients being investigated for CAD. | Caryl Elizabeth Richards Stephen Dorman Patricia John Anthony Davies Sharon Evans Tishi Ninan David Martin Sriranj Kannoly Gail Roberts-Davies Mark Ramsey Daniel Rhys Obaid | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT OF MEN WITH SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC ENLARGEMENT: THE CLasP STUDY显示文摘 | JENNY L. DONOVAN TIM J. PETERS DAVID E. NEAL SARA T. BROOKES SANDEEP GUJRAL K. NINAN CHACKO MARK WRIGHT L. GAIL KENNEDY PAUL ABRAMS | 2000 | The Journal of Urology2000，，1： | 3 |
| 3 | Effectiveness and safety of auricular acupoint bloodletting in treatment of insomnia:an assessor-blinded pilot randomized controlled trial显示文摘OBJECTIVE: To evaluate the effectiveness and safety of auricular acupoint bloodletting in treatment of insomniaMETHODS: Participants(n = 60) with insomnia were randomized into two groups to receive treatment of auricular acupoint bloodletting: low frequency group, 1 times/week for five weeks(n = 30);high frequency group, 2 times/week for two weeks(n = 30). The following outcomes were measured blindly at baseline, after first treatment, 4 weeks,and 8 weeks: Pittsburgh sleep quality index scale(PSQI).RESULTS: The groups were balanced at baseline for insomnia and demographic characteristics. There were no significant differences between the groups in terms of any of the outcomes, at the first follow-up time point. However, the therapeutic effect of LFG(once per week) is obviously lower than that of HFG(twice per week). In addition, there was no significant difference in the side effects between the two groups.CONCLUSION: The treatment of insomnia with different frequencies of auricular acupoint bloodletting is effective and has less side effects. More reasonable treatment frequencies are worth further study. | Ni Jing Wang Bin Wang Fuzhuang Zhou Hongwei Shi Huaxin Zhang Ninan Zhao Hong Xie Qi | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 2 |
| 4 | Synthesis and properties of polyether nitrile copolymers with pendant methyl groups显示文摘 | Saxena A Rao V L Ninan K N | 2003 | European Polymer Journal2003，39，： | 1 |
| 5 | Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMK II 显示文摘 | Liu S Fa M Ninan I Trinchese F Dauer W Arancio O | 2007 | Eur J Neurosci2007，25，12： | 1 |
| 6 | Investigations on the cure chemistry and polymer properties of benzoxazine - eyanate ester blends显示文摘 | Santhosh Kumar K S Reghunadhan Nair C P Ninan K N | 2009 | European Polymer Journal2009，45，2： | 1 |
| 7 | Brittle asthma显示文摘 | Ayres JG Jyothish D Ninan T | | 0，，： | 1 |
| 8 | Synthesis and prop- erties of polyether nitrile copolymers with pendant methyl groups 显示文摘 | Saxena A Rao V L Ninan K N | 2003 | European Polymer Journal2003，39，： | 1 |
| 9 | DSC study on the effect of isoeyanates and catalysts on the HTPB cure reaction 显示文摘 | Korah Bina C Kannan K G Ninan K N | 2004 | Journal of Thermal Analysis and Calorimetry2004，78，3： | 1 |
| 10 | Adjunctive modafinil at initiation of treatment with a selective serotonin reuptake inhibitor enhances the degree and onset of therapeutic effects in patients with major depressive disorder and fatigue显示文摘 | Ninan PT Hassman HA Giass SJ | 2004 | J Clin Psychiatry2004，65，3： | 1 |
| 11 | Synthesis and properties of poly ether nitrile copolymers with pendant methyl groups 显示文摘 | SAXENA A RAO V L NINAN K N | 2003 | Eur Polym J2003，39，： | 1 |
| 12 | Effect of polymeric additives on properties of glass bisphenol A dicyanate laminate composites 显示文摘 | Mathew Do Reghunadhan N C P Ninan K N | 2000 | J Appl Polym Sci2000，77，： | 1 |
| 13 | The exonomics of biodiversity conservation:a study of a coffee growing region in the Western Ghats of India 显示文摘 | K N Ninan Jyothis Sathyapalan | 2005 | Ecological Econ2005，55，1： | 1 |
| 14 | Phosphazene Triazine Cyclomatrix Network Polymers:Some Aspects of Synthesis, Thermal- and Flame-retardant Characteristics显示文摘 | Mathew D Nair C P R Ninan K N | 2000 | Polym Int2000，49，1： | 1 |
| 15 | Addition-cure-type phenolic resin based on alderene reaction: Synthesis and laminate composite properties 显示文摘 | Bindu RL Reghunadhan Nair CP Ninan KN | 2001 | Journal of Applied Polymer Science2001，80，5： | 1 |
| 16 | Modeling of modularity and scaling for integration of customer in design of engineer-to-or- der products 显示文摘 | Zahed Siddique Jiju A Ninan | 2006 | Integrated Computer-Aided Engineering2006，13，2： | 1 |
| 17 | Fourier transform infrared and wide-angle X-ray diffraction studies of the thermal cyclization reactions of high-molar-mass poly ( acrylonitrile-co-itaconic acid) 显示文摘 | Devasia R Nair CR P Sadhana R Babu N S Ninan K N | 2006 | Journal of Applied Polymer Science2006，100，： | 1 |
| 18 | Studies on the adhesive properties of solid elastomer-modified novolac epoxy resin显示文摘 | Gouri C Ramasamy R Ninan K N | | 0，，： | 1 |
| 19 | Pectin/carboxymethylcellulose/microfibrillated cellulose composite scaffolds for tissueengineering显示文摘 | Ninan N Muthiah M park I K | 2013 | Carbohydr Polym2013，98，1： | 1 |
| 20 | Phenolic resins bearing maleimide functions ; synthesis and characterisation 显示文摘 | Reghunadhan Nair CP Bindu RL Ninan KN | 2000 | Journal of Applied Polymer Science Part A Polymer Chemistry2000，38，2： | 1 |
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