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| 1 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 2 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 6 | Survival of glass fibre reinforced composite post restorations after 2 years-an observational clinical study 显示文摘 | Naumarm M Blankenstein F Dietrich T | 2005 | ] Dent2005，33，4： | 1 |
| 7 | Small diffemnces in-tntlschemlc brain temperature critically determine the extent of is-chemic neuronal injury显示文摘 | Dietrich WD Globus M | 1987 | J Cereb Blood Flow Metab1987，7，： | 1 |
| 8 | Death don't have no mercy: Cell death programs in plant-microbe interactions 显示文摘 | Dangl J L Dietrich R A Richberg M H | 1996 | Plant Cell1996，8，： | 1 |
| 9 | Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice显示文摘 | Mayr U Mayr M Li CH Wernig F Dietrich H Hu Y | 2002 | Circ Res2002，90，2： | 1 |
| 10 | An Arabidopsis aspartic protease functions as an anti-cell death component in repro- duction and embryogenesis 显示文摘 | Ge X Dietrich C Matsuno M | 2005 | EMBO Rep2005，6，： | 1 |
| 11 | Low-dose high- resolution CT of the petrous bone 显示文摘 | Husstedt HW Prokop M Dietrich B | 2001 | J Neuroradiol2001，27，： | 1 |
| 12 | Systematic investigation of cracks in encapsulated solar cells after mechanical loading显示文摘 | Sander M Dietrich S Pander M | 2013 | Solar Energy Materials and Solar Cells2013，111，： | 1 |
| 13 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 14 | Non - linear waveform inversion of plane wave seismograms in stratified elastic media显示文摘 | KORMENDI F DIETRICH M | 1991 | Geophysics1991，56，： | 1 |
| 15 | Photochemistry on metal nanoparticles显示文摘 | DIETRICH M NIKLAS N | 2006 | Chemical Reviews2006，106，10： | 1 |
| 16 | Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease显示文摘 | Dietrich T Jimenez M Krall Kaye EA | 2008 | Circulation2008，117，13： | 1 |
| 17 | High levels of human chorionic gonadotropin (hCG) correlate with increased aquaporin -9 (AQP9) expression in explants from human preeclamptic placenta显示文摘 | Marino GI Castro - Parodi M Dietrich V | 2010 | Reprod Sci2010，17，5： | 1 |
| 18 | A point-of-care assessment of the effects ofdesmopressin on impaired platelet function using multiple electrode whole-bloodaggregometry in patients after cardie surgeiy显示文摘 | Weber CF Dietrich W Spannaql M | 2010 | Anesth Analg2010，110，3： | 1 |
| 19 | Sonographic assessment of splanchnic arteries and the bowel wall显示文摘 | DIETRICH C F JEDRZEJCZYK M IGNEE A | 2007 | Eur JRadiol2007，64，： | 1 |
| 20 | Control of pulp levels in flotation cells 显示文摘 | Jamsa-Jounela S L Dietrich M Halmevaara K | 2003 | Control Engineering Practice2003，11，： | 1 |
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