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| 1 | 慢生花生根瘤菌的遗传多样性研究(英文)显示文摘用REP1R1和REP21DNA为引物,对22株四川土著慢生花生根瘤菌染色体DNA的基因外回文重复序列(RepetitiveExtrogenicpalindromicsequenceREP)进行了PCR扩增和凝胶电泳,并对电泳结果的指纹图型进行了相似性聚类分析.结果表明了四川土著慢生花生根瘤菌的遗传多样性. | 张小平 李登煜 NICK Giselle LINDSTR M Kristina | 1998 | 应用与环境生物学报1998，4，1： | 9 |
| 2 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 3 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 4 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 5 | Grid services, for distributed system integration显示文摘 | Foster I Kesselman C Nick J M | 2002 | Compute2002，35，6： | 1 |
| 6 | Phytomining 显示文摘 | BR()( )KS R R CHAMBERS M F NICKS J | 1998 | Trends in Plan* Sci1998，3，9： | 1 |
| 7 | Farming for metals显示文摘 | Nicks L J Chambers M F | 1995 | Mining Environmental Management1995，3，3： | 1 |
| 8 | Using soil erosion models for global change studies 显示文摘 | Williams J Nearing M Nicks A | 1996 | Journal of Soil and Water Conservation1996，51，38： | 1 |
| 9 | A randomized, pharmacokinetic and pharmacodynamic, cross-over study of duodenal or jejunal administration compared to nasogastric administration of omeprazole suspension in patients at risk for stress ulcers显示文摘 | Jeffrey O Phillips Keith M Olsen Jill A Rebuck Nick J Rangnekar Brent W Miedema Michael H Metzler | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 10 | Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Aetlvin and Inhibin 显示文摘 | NICKS K M PERRIEN D S AKEL N S | 2009 | Mol Cell Endocrinol2009，310，12： | 1 |
| 11 | A Cluster Analysis of the KM field显示文摘 | Moharmnad H R M Nick Bontis | 2009 | Management Decision2009，47，5： | 1 |
| 12 | Recombinant human ac-tivated protein C reduces human endotoxin-induced pulmonary in-flammation via inhibition of neutrophil chemotaxis显示文摘 | Nick J A Coldren C D Geraci M W | 2004 | Blood2004，104，13： | 1 |
| 13 | Update on buffer sizing in internet routers 显示文摘 | YASHAR G NICK M | 2006 | ACM SIGCOMM Computer Communication Review2006，36，5： | 1 |
| 14 | Venousthromboembolic events in minimally invasive gynecologicsurgery 显示文摘 | Ramirez PT Nick AM Frumovitz M | 2013 | J Minim Invasive Gynecol2013，20，6： | 1 |
| 15 | Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels显示文摘 | Masato Kato Tina W. Han Shanhai Xie Kevin Shi Xinlin Du Leeju C. Wu Hamid Mirzaei Elizabeth J. Goldsmith Jamie Longgood Jimin Pei Nick V. Grishin Douglas E. Frantz Jay W. Schneider She Chen Lin Li Michael R. Sawaya David Eisenberg Robert Tycko Steven L. M | 2012 | Cell2012，，： | 1 |
| 16 | Motion estimation using a complex-valued wavelet transform显示文摘 | JULIAN M NICK K | 1998 | IEEE Transactions on Signal Processing1998，46，4： | 1 |
| 17 | Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis 显示文摘 | Nick J A Coldren C D Geraci M W | 2004 | Blood2004，104，13： | 1 |
| 18 | Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer显示文摘 | HEASLEY L E THALER S NICKS M | 1997 | J Biol Chem1997，272，14： | 1 |
| 19 | ZnO thin films by MOCVD显示文摘 | Nick M Sbrockey Shanthi Ganesan | 2004 | III -Vs Review2004，17，7： | 1 |
| 20 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species显示文摘 | REBECCA N S JOHN C K NICK M M | 2000 | Fuel Processing Technology2000，6566，： | 1 |
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