|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 2 | HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption显示文摘 | Ioanna Papandreou Rob A. Cairns Lucrezia Fontana Ai Lin Lim Nicholas C. Denko | 2006 | Cell Metabolism2006，，3： | 2 |
| 3 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 4 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，9： | 1 |
| 5 | The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography显示文摘 | Jung Yul Lim Andrea D. Dreiss Zhiyi Zhou Joshua C. Hansen Christopher A. Siedlecki Robert W. Hengstebeck Juan Cheng Nicholas Winograd Henry J. Donahue | 2006 | Biomaterials2006，，： | 1 |
| 6 | Hospitalization for variceal hemorrhage in an era with more prevalent cirrhosis显示文摘AIM: To examine hospitalization rates for variceal hemorrhage and relation to cause of cirrhosis during an era of increased cirrhosis prevalence.METHODS: We performed a retrospective review of patients with cirrhosis and gastroesophageal variceal hemorrhage who were admitted to a tertiary care referral center from 1998 to 2009. Subjects were classified according to the etiology of their liver disease: alcoholic cirrhosis and non-alcoholic cirrhosis. Rates of hospitalization for variceal bleeding were determined. Data were also collected on total hospital admissions per year and cirrhosis-related admissions per year over the same time period. These data were then compared and analyzed for trends in admission rates.RESULTS: Hospitalizations for cirrhosis significantly increased from 611 per 100000 admissions in 1998-2001 to 1232 per 100000 admissions in 2006-9(P value for trend < 0.0001). This increase was seen in admissions for both alcoholic and non-alcoholic cirrhosis(P values for trend < 0.001 and < 0.0001 respectively). During the same time period, there were 243 admissions for gastroesophageal variceal bleeding(68% male, mean age 54.3 years, 62% alcoholic cirrhosis). Hospitalizations for gastroesophageal variceal bleeding significantly decreased from 96.6 per 100000 admissions for the time period 1998-2001 to 70.6 per 100000 admissions for the time period 2006-2009(P value for trend = 0.01). There were significant reductions in variceal hemorrhage from non-alcoholic cirrhosis(41.6 per 100000 admissions in 1998-2001 to 19.7 per 100000 admissions in 2006-2009, P value for trend = 0.007). CONCLUSION: Hospitalizations for variceal hemorrhage have decreased, most notably in patients with non-alcoholic cirrhosis, and this may reflect broader use of strategies to prevent bleeding. | Nicholas Lim Michael J Desarno Steven D Lidofsky Eric Ganguly | 2014 | World Journal of Gastroenterology2014，20，32： | 1 |
| 7 | Impact on 30-d readmissions for cirrhotic patients with ascites after an educational intervention: A pilot study显示文摘BACKGROUND A low proportion of patients admitted to hospital with cirrhosis receive quality care with timely paracentesis an important target for improvement.We hypothesized that a medical educational intervention,delivered to medical residents caring for patients with cirrhosis,would improve quality of care.AIM To determine if an educational intervention can improve quality of care in cirrhotic patients admitted to hospital with ascites.METHODS We performed a pilot prospective cohort study with time-based randomization over six months at a large teaching hospital.Residents rotating on hospital medicine teams received an educational intervention while residents rotating on hospital medicine teams on alternate months comprised the control group.The primary outcome was provision of quality care-defined as adherence to all quality-based indicators derived from evidence-based practice guidelines-in admissions for patients with cirrhosis and ascites.Patient clinical outcomesincluding length of hospital stay(LOS);30-d readmission;in-hospital mortality and overall mortality-and resident educational outcomes were also evaluated.RESULTS Eighty-five admissions(60 unique patients)met inclusion criteria over the study period-46 admissions in the intervention group and 39 admissions in the control group.Thirty-seven admissions were female patients,and 44 admissions were for alcoholic liver disease.Mean model for end-stage liver disease(MELD)-Na score at admission was 25.8.Forty-seven(55.3%)admissions received quality care.There was no difference in the provision of quality care(56.41%vs 54.35%,P=0.9)between the two groups.30-d readmission was lower in the intervention group(35%vs 52.78%,P=0.1)and after correction for age,gender and MELD-Na score[RR=0.62(0.39,1.00),P=0.05].No significant differences were seen for LOS,complications,in-hospital mortality or overall mortality between the two groups.Resident medical knowledge and self-efficacy with paracentesis improved after the educational intervention.CONCLUSION Medical education has the potential to improve clinical outcomes in patients admitted to hospital with cirrhosis and ascites. | Nicholas Lim Otto Sanchez Andrew Olson | 2019 | World Journal of Hepatology2019，11，10： | 1 |
| 8 | Cellular reaction to hypoxia: sensing and responding to an adverse environment显示文摘 | Ioanna Papandreou Ashley Powell Ai Lin Lim Nicholas Denko | 2004 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2004，，1： | 1 |
| 9 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，9： | 1 |
| 10 | Thrombus Aspiration Alone: A Potential Strategy in ST Elevation Myocardial Infarction Intervention显示文摘 | Fei Chong Nicholas Cox Yean Lim | 2011 | Heart Lung and Circulation2011，，11： | 1 |
| 11 | A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia显示文摘Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid modulation.Methods:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH patients.Treatments were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the analysis.Bile acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with placebo.The top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with placebo.SUCRA found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile acids.Conclusions:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic dyslipidemia.Future studies are required to evaluate the cardiovascular outcomes. | Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan Wen-Hui Lim Grace Lim Jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun J.Sanyaland Mark D.Muthiah | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
| 12 | Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models显示文摘In addition to their canonical roles in regulating cell cycle transition and transcription,cyclin-dependent kinases(CDKs)have been shown to coordinate DNA damage response pathways,suggesting a rational pairing of CDK inhibitors with genotoxic chemotherapeutic agents in the treatment of human malignancies.Here,we report that roniciclib(BAY1000394),a potent pan-CDK inhibitor,displays promising anti-neoplastic activity as a single agent and potentiates cisplatin lethality in preclinical nasopharyngeal carcinoma(NPC)models.Proliferation of the NPC cell lines HONE-1,CNE-2,C666-1,and HK-1 was effectively curbed by roniciclib treatment,with IC_(50)values between 11 and 38 nmol/L.These anticancer effects were mediated by pleiotropic mechanisms consistent with successful blockade of cell cycle CDKs 1,2,3,and 4 and transcriptional CDKs 7 and 9,ultimately resulting in arrest at G1/S and G2/M,downregulation of the transcriptional apparatus,and repression of anti-apoptotic proteins.Considerably enhanced tumor cell apoptosis was achieved following combined treatment with 10 nmol/L roniciclib and 2.0μmol/L cisplatin;this combination therapy achieved a response over 250%greater than either drug alone.Although roniciclib chemosensitized NPC cells to cisplatin,it did not sensitize untransformed(NP69)cells.The administration of 0.5 mg/kg roniciclib to BALB/c xenograft mice was well tolerated and effectively restrained tumor growth comparable to treatment with 6 mg/kg cisplatin,whereas combining these two agents produced far greater tumor suppression than either of the monotherapies.In summary,these data demonstrate that roniciclib has strong anti-NPC activity and synergizes with cisplatin chemotherapy at clinically relevant doses,thus justifying further evaluation of this combinatorial approach in clinical settings. | Nicholas LSyn Pei Li Lim Li Ren Kong Lingzhi Wang Andrea Li-Ann Wong Chwee Ming Lim Thomas Kwok Seng Loh Gerhard Siemeister Boon Cher Goh Wen-Son Hsieh | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 13 | Neither autophagy nor exercise training mode affect exercise-induced beneficial adaptations in high fat-fed mice显示文摘Exercise mitigates obesity-associated pathologies;however,there is controversy regarding optimal exercise interventions.Autophagy,is known to decrease during obesity and is an important moderator for exercise adaptations.Purpose:To investigate individual and combined effects of different exercise interventions and autophagy inhibition on exercise adaptations during obesity.Methods:C57BL/6J mice initiated 45%high fat diet at 8 weeks of age.After 6 weeks of diet,animals were divided into moderate(MOD)or high intensity interval training interventions(HIIT),animals were further divided into autophagy inhibition or vehicle conditions(n=10/group).Animals exercised and autophagy was inhibited 3X/week by NSC185058 injections,thereby blocking autophagosome formation.Interventions continued for 4 weeks.Results:High fat diet impaired glucose handling~17%;exercise interventions normalized glucoregulation to prehigh fat diet levels,without differences between any interventions.High fat diet induced~25%decrease in aerobic capacity,which returned to baseline after exercise interventions,with no differences between any interventions.No effects of autophagy inhibition were noted.Conclusions:HIIT and MOD training confer similar health-related adaptations. | Megan E.Rosa-Caldwell Lisa T.Jansen Seongkyun Lim Kirsten R.Dunlap Wesley S.Haynie Tyrone A.Washington Nicholas P.Greene | 2020 | Sports Medicine and Health Science2020，2，1： | 0 |
| 14 | Development and progression of cancer cachexia:Perspectives from bench to bedside显示文摘Cancer cachexia(CC)is a devastating syndrome characterized by weight loss,reduced fat mass and muscle mass that affects approximately 80%of cancer patients and is responsible for 22%-30%of cancer-associated deaths.Understanding underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer outcomes.CC is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting;however,CC can impair other organs such as the liver,heart,brain,and bone as well.A considerable amount of CC research focuses on changes that occur within the muscle,but cancer-related impairments in other organ systems are understudied.Furthermore,metabolic changes in organ systems other than muscle may contribute to CC.Therefore,the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body perspective.Outlining the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat CC.As much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from preclinical models. | Seongkyun Lim Jacob L.Brown Tyrone A.Washington Nicholas P.Greene | 2020 | Sports Medicine and Health Science2020，2，4： | 0 |
| 15 | Lymphangitic spread from appendiceal adenocarcinoma to ileocecal valve, mimicking Crohn's disease显示文摘Due to the anatomical peculiarity of the appendix,diagnosis of tumors arising from this area can be challenging by clinicoradiologic means.We report a case of a rare primary appendiceal signet ring carcinoma with an uncommon presentation.An 86-year-old woman was admitted toour hospital with subacute epigastric pain.Computed tomography demonstrated bowel wall thickening with fat stranding in the ileocecal region.The leading diagnostic consideration was inflammatory bowel disease.Upon colonoscopy,a swollen,distorted ileocecal valve was identified.The remaining colon was otherwise unremarkable.Extensive biopsy sampling of the ileocecal region and colon was performed.A lymphangitic signet ring carcinoma within the ileocecal region was diagnosed on biopsy;there was no dysplasia or carcinoma of the remaining biopsies.By cytomorphology and immunoprofile,a lymphangitic signet ring carcinoma of appendiceal origin was the primary consideration,further confirmed upon subsequent laparotomy.This case represents an unusual pattern of appendiceal tumor spread with localized,lymphangitic involvement,creating a milieu which closely simulates Crohn’s disease on imaging modalities. | Tricia Murdock Nicholas Lim Maryam Zenali | 2015 | World Journal of Gastroenterology2015，21，7： | 0 |
| 16 | PNAS:科学家或成功实现利用基因疗法来治疗阿尔兹海默氏症显示文摘日前,来自帝国理工学院的研究人员通过利用病毒将特殊的基因片段运输到小鼠大脑中,从而成功抑制小鼠患阿尔兹海默氏症,相关研究刊登于国际杂志PNAS上,该研究或为后期开发治疗诸如阿尔兹海默氏症等神经性疾病的新型疗法提供思路。 | Loukia Katsouri Yau M. Lim Katrin Blondrath Ioanna Eleftheriadou Laura Lombardero Amy M. Birch Nazanin Mirzaei Elaine E. Irvine Nicholas D. Mazarakis Magdalena Sastre | 2017 | 现代生物医学进展2017，17，4： | 0 |
| 17 | Foregut bypass vs.restrictive bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals显示文摘Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological outcomes.Thus,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with NAFLD.Methods:Medline and Embase were searched for articles relating to bariatric procedures and NAFLD.Pairwise meta-analysis was conducted to compare efficacy of bariatric procedures pre-vs.post-procedure with subgroup analysis to further compare restrictive against foregut bypass procedures.Results:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were included.Both foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis resolution.Compared to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive procedures.No significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management. | Wen Hui Lim Snow Yunni Lin Cheng Han Ng Darren Jun Hao Tan Jieling Xiao Jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin Arun J.Sanyal Mohammad Shadab Siddiqui Mark D.Muthiah | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员