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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 3 | Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study显示文摘 | J. Tischendorf H. Wasmuth A. Koch H. Hecker C. Trautwein R. Winograd | 2007 | Endoscopy2007，，12： | 2 |
| 4 | HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR显示文摘 | Klase Z Kale P Winograd R | 2007 | BMC Molecular Biology2007，8，： | 1 |
| 5 | Uterine artery embolization for postpartum hemorrhage 显示文摘 | Winograd RH | 2008 | Best Pract Res Clin Obstet Gynaecol2008，12，6： | 1 |
| 6 | prevention of post-surgical adhesion formation using aspirin in a rodent model report显示文摘 | Golan A Maymon R Winograd I | 1995 | Hum Reprod1995，10，7： | 1 |
| 7 | The Complex Trial Protocol (CTP) : A new, countermeasure-resistant, accurate P300-based method for detection of concealed informa- tion 显示文摘 | Rosenfeld J P Labkovsky E Lui M A Winograd M Van- denboom C & Chedid K | 2008 | Psychophysiology2008，45，： | 1 |
| 8 | Uterine artery embolization for postpartum hemorrhage 显示文摘 | Winograd RH | 2008 | Best Pract Res Clin Obstet Gynaecol2008，22，6： | 1 |
| 9 | The interactive workspaces project: Experiences with ubiquitous computing rooms 显示文摘 | JOHANSON B FOX A WINOGRAD T | 2002 | IEEE Pervasive Computing2002，1，2： | 1 |
| 10 | A language/action perspective on the design of cooperative work 显示文摘 | Winograd T | 1988 | ACM SIGCHI Bulletin1988，20，1： | 1 |
| 11 | Activity and cellular onigin of gelatinases in patients with colon and rectal carcinoma显示文摘 | Koprowski E Dietrich CG Winograd R | 2008 | Cancer2008，92，： | 1 |
| 12 | Successful distraction osteogenesis across a growing cranial suture without an osteotomy 显示文摘 | Tung TH Robertson BR Winograd JM | 1999 | Plast Reconstr Surg1999，103，2： | 1 |
| 13 | Cancer Inst 显示文摘 | Onetto N Canett R Winograd B | 1993 | monogr1993，，15： | 1 |
| 14 | LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms显示文摘 | KING C E WANG L WINOGRAD R MADISON B B | 2011 | Oncogene2011，30，： | 1 |
| 15 | On computing the discrete Fourier transform Proc显示文摘 | WINOGRAD S | 1976 | Nat Acad Sci USA1976，，10： | 1 |
| 16 | Fast Algorithms for the Discrete Cosine Transform显示文摘 | FEIG E WINOGRAD S | 1992 | IEEE Transactions on Signal Processing1992，40，9： | 1 |
| 17 | Perinatal lethality and multiple craniofacial malformations in Msx 2 transgenic mice显示文摘 | Winograd J Reilly MP Roe R | 1997 | Hum Molec Genet1997，6，： | 1 |
| 18 | Activity and cellular origin of gelatinases in patients with colon and rectal carcinoma显示文摘 | Roeb E Dietrich CG Winograd R | 2010 | Cancer2010，92，： | 1 |
| 19 | The relative contributions of summer and cool-season precipitation to groundwater recharge, Spring Mountains, Nevada, USA显示文摘 | Winograd I J Riggs AC Coplen TB | 1998 | Hydrogeology Journal1998，6，1： | 1 |
| 20 | Successful distraction osteogenesis aross a growing cranial suture without an osteotomy 显示文摘 | Tung TH Robertson BR Winograd JM | 1999 | Plast Reconstr Surg1999，103，2： | 1 |
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