共被期刊论文引用了2次
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| 1 | 缺氧与脂肪组织胰岛素抵抗显示文摘肥胖患者脂肪细胞肥大导致缺氧,缺氧诱导因子1α(HIF-1α)高度表达。缺氧使得糖稳态失衡,HIF-1α调控细胞外基质蛋白高度表达导致脂肪组织纤维化、炎性反应,引起脂肪组织功能紊乱,最终导致胰岛素抵抗。 | 杨朝强 李赟晨 黄芳 | 2015 | 大家健康(学术版)2015，，11： | 1 |
| 2 | Glucose metabolic phenotype of pancreatic cancer显示文摘AIM: To construct a global 'metabolic phenotype' of pancreatic ductal adenocarcinoma(PDAC) reflecting tumour-related metabolic enzyme expression.METHODS: A systematic review of the literature was performed using Ovid SP and Pub Med databases using keywords 'pancreatic cancer' and individual glycolytic and mitochondrial oxidative phosphorylation(MOP) enzymes. Both human and animal studies investigating the oncological effect of enzyme expression changes and inhibitors in both an in vitro and in vivo setting were included in the review. Data reporting changes in enzyme expression and the effects on PDAC cells, such as survival and metastatic potential, were extracted to construct a metabolic phenotype. RESULTS: Seven hundred and ten papers were initially retrieved, and were screened to meet the review inclusion criteria. 107 unique articles were identified as reporting data involving glycolytic enzymes, and 28 articles involving MOP enzymes in PDAC. Data extraction followed a pre-defined protocol. There is consistent over-expression of glycolytic enzymes and lactate dehydrogenase in keeping with the Warburg effect to facilitate rapid adenosine-triphosphate production from glycolysis. Certain isoforms of these enzymes were over-expressed specifically in PDAC. Altering expression levels of HK, PGI, FBA, enolase, PK-M2 and LDA-A with metabolic inhibitors have shown a favourable effect on PDAC, thus identifying these as potential therapeutic targets. However, the Warburg effect on MOP enzymes is less clear, with different expression levels at different points in the Krebs cycle resulting in a fundamental change of metabolite levels, suggesting that other essential anabolic pathways are being stimulated. CONCLUSION: Further characterisation of the PDAC metabolic phenotype is necessary as currently there are few clinical studies and no successful clinical trials targeting metabolic enzymes. | Anthony KC Chan Jason IE Bruce Ajith K Siriwardena | 2016 | World Journal of Gastroenterology2016，22，12： | 0 |
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