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| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 3 | Enhancement of enzymatic fibrinolysis with 2-MHz ultrasound and microbubbles显示文摘 | Cintas P Nguyen F Boneu B | 2004 | Thromb Haemost2004，2，7： | 1 |
| 4 | Macrophage accumulation in human progressive diabetic nephropathy显示文摘 | Nguyen D Ping F Mu W | 2006 | Nephrology (Carlton)2006，11，3： | 1 |
| 5 | Water-soluble poly (aniline- co-o-anthranilicacid) copolymers 显示文摘 | Nguyen M T Diaz A F | 1995 | Macromolecules1995，28，9： | 1 |
| 6 | Effectiveness of imageguided radiotherapy for locally advanced rectal Cancer显示文摘 | Nguyen NP Ceizyk M Almeida F | | 0，，02： | 1 |
| 7 | Applications of CFD in hydraulics and river engineering显示文摘 | Nguyen V Nestmann F | | 0，，2： | 1 |
| 8 | Physically Based Modeling and Animation of Fire 显示文摘 | Nguyen D Q Ronald F Jensen H W | 2002 | ACM Transactions on Graphics2002，21，3： | 1 |
| 9 | Severe sepsis and septic shock:review of the literature and emergency department management guidelines显示文摘 | Nguyen H B Rivers E P Abrahamiam F M | 2006 | Ann Emerg Med2006，48，1： | 1 |
| 10 | A proba- bilistic model for the vulnerability of metal plates un- der the impact of cylindrical projectiles 显示文摘 | Mebarki A Nguyen Q B Mercier F | 2007 | Journal of Loss Prevention in the Process Industries2007，20，2： | 1 |
| 11 | Adaptive response surface method based on a double weighted regression technique 显示文摘 | Nguyen X S Sellier A Duprat F | 2009 | Probabilistic Engineering Mechanics2009，24，2： | 1 |
| 12 | Scalp nerve blocks decrease the severity of pain after craniotomy显示文摘 | Nguyen A Girard F Boudreault D | 2001 | Anesth Analg2001，93，5： | 1 |
| 13 | SIRT2 deacetylates FOXO3a in re- sponse to oxidative stress and caloric restriction显示文摘 | Wang F Nguyen M Qin FX | 2007 | Aging Ce112007，6，4： | 1 |
| 14 | Single event effect characterization of high density commercial NAND and NOR nonvolatile flash memories 显示文摘 | IROM F NGUYEN D N | 2007 | IEEE Transactions on Nuclear Science2007，54，6： | 1 |
| 15 | Prognosis and prediction of response to surgery in allergi patients with chronic sinusitis显示文摘 | LAVIGNE F NGUYEN C T CAMERON L | 2002 | J Allergy Clin Immunol2002，105，： | 1 |
| 16 | Etch-stop characteristics of Sc2O3 and HfO2 films for multilayer dielectric grating applications显示文摘 | Britten J A Nguyen H T Falabella S F | 1996 | J Vac Sci Technol A1996，14，5： | 1 |
| 17 | Reliabili- ty analysis of metallic targets under metallic rods im- pact: towards a simplified probabilistic approach 显示文摘 | Mebarki A Nguyen Q B Mercier F | 2008 | Journal of Loss Prevention in the Process Industries2008，21，5： | 1 |
| 18 | AT( 1 ) receptor antagonist therapy preferentially ameliorated right ventricular function and phenotype during the early phase of remodelingpost - MI 显示文摘 | Nguyen QT Colombo F Clement R | 2003 | Br J Pharmacol2003，138，8： | 1 |
| 19 | The structure of haplotype blocks in the human genome 显示文摘 | GABRIEL S B SEHAFFNER S F NGUYEN H | 2002 | Science2002，296，5576： | 1 |
| 20 | Applications of CFD in hydraulics and river engineering 显示文摘 | NGUYEN V NESTMANN F | 2006 | International Journal of Computational Fluid Dynamics2006，18，2： | 1 |
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