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| 1 | Differential diagnosis in inflammatory bowel disease colitis:State of the art and future perspectives显示文摘Distinction between Crohn's disease of the colonrectum and ulcerative colitis or inflammatory bowel disease(IBD) type unclassified can be of pivotal importance for a tailored clinical management,as each entity often involves specific therapeutic strategies and prognosis.Nonetheless,no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations.Hence,we have performed a literature search to address the problem of differential diagnosis in IBD colitis,revised current and emerging diagnostic tools and refined disease classification strategies.Nowadays,the differential diagnosis is an untangled issue,and the proper diagnosis cannot be reached in up to 10% of patients presenting with IBD colitis.This topic is receiving emerging attention,as medical therapies,surgical approaches and leading prognostic outcomes require more and more disease-specific strategies in IBD patients.The optimization of standard diagnostic approaches based on clinical features,biomarkers,radiology,endoscopy and histopathology appears to provide only marginal benefits.Conversely,emerging diagnostic techniques in the field of gastrointestinal endoscopy,molecular pathology,genetics,epigenetics,metabolomics and proteomics have already shown promising results.Novel advanced endoscopic imaging techniques and biomarkers can shed new light for the differential diagnosis of IBD,better reflecting diverse disease behaviors based on specific pathogenic pathways. | Gian Eugenio Tontini Maurizio Vecchi Luca Pastorelli Markus F Neurath Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，1： | 13 |
| 2 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 3 | New endoscopic approaches in IBD显示文摘Recent advances in endoscopic imaging techniques have revolutionized the diagnostic approach of patients with inflammatory bowel disease(IBD).New,emerging endoscopic imaging techniques visualized a plethora of new mucosal details even at the cellular and subcellular level.This review offers an overview about new endoscopic techniques,including chromoendoscopy,magnification endoscopy,spectroscopy,confocal laser endomicroscopy and endocytoscopy in the face of IBD. | Helmut Neumann Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | 东方蜜蜂高效的卫生行为机制对于西方蜜蜂抗病育种的启示显示文摘西方蜜蜂(Apismellifera)在世界各地大范围的蜂群损失现象已引起科学界和公众的广泛关注,其健康状况与东方蜜蜂(Apis cerana)相比明显较劣。东方蜜蜂群内可检测到的病原体和寄生虫相对较少,即它们对于生物威胁具有更强的抵抗力,即便是面对异种入侵的新病原(如蜜蜂残翅病毒)。 | Lin Z Page P Li L Qin Y Zhang Y Hu F Neumann P Zheng H Dietemann V 蔺哲广 郑火青 胡福良 | 2016 | 中国蜂业2016，67，12： | 5 |
| 5 | First case report of exacerbated ulcerative colitis after anti-interleukin-6R salvage therapy显示文摘We present the case of a 53-year-old woman with long-standing ulcerative colitis and severe, steroid-dependent disease course unresponsive to treatment with azathioprine, methotrexate, anti-TNF antibodies(infliximab, adalimumab) and tacrolimus, who refused colectomy as a therapeutic option. As the pro-inflammatory cytokine interleukin-6(IL-6) had been identified as a crucial regulator in the immunopathogenesis of inflammatory bowel diseases, we treated the patient with biweekly intravenous infusions of an anti-IL-6R antibody(tocilizumab) for 12 wk. However, no clinical improvement of disease activity was noted. In fact, endoscopic, histological and endomicroscopic assessment demonstrated exacerbation of mucosal inflammation and ulcer formation upon anti-IL-6R therapy. Mechanistic studies revealed that tocilizumab treatment failed to suppress intestinal IL-6 production, impaired epithelial barrier function and induced production of pro-inflammatory cytokines such as TNF, IL-21 and IFN-γ. Inhibition of IL-6 by tocilizumab had no clinical benefit in this patient with intractable ulcerative colitis and even led to exacerbation of mucosal inflammation. Our findings suggest that anti-IL-6R antibody therapy may leadto aggravation of anti-TNF resistant ulcerative colitis. When targeting IL-6, the differential responsiveness of target cells has to be taken into account, as IL-6 on the one side promotes acute and chronic mucosal inflammation via soluble IL-6R signaling but on the other side also strongly contributes to epithelial cell survival via membrane bound IL-6R signaling. | Raja Atreya Ulrike Billmeier Timo Rath Jonas Mudter Michael Vieth Helmut Neumann Markus F Neurath | 2015 | World Journal of Gastroenterology2015，21，45： | 5 |
| 6 | Influence of the layer charge and clay particle size on the interactions between the cationic dye methylene blue and clays in an aqueous suspension显示文摘 | NEUMANN M G GESSNER F SCHMITT C C | 2002 | J Colloid Interface Sci2002，255，： | 2 |
| 7 | Kinematic modeling of wheeled mobile robots 显示文摘 | MUIR P F NEUMANN C P | 1987 | J Robotics Systems1987，4，2： | 2 |
| 8 | Vessel size and long-term outcome after coronary stent placement显示文摘 | Eleizi S Kastrati A Neumann F | 1998 | Circulation1998，98，18： | 1 |
| 9 | The auditing standard of consistency显示文摘 | | 1968 | Journal of Accounting Research1968，，9： | 1 |
| 10 | Interactions between signaling pathways in mediating GnRH-stimulated GTH release from goldfish pituitary cells:protein kinase C,but not cyclic AMP is an important mediator of GnRH-stimulated gonadotropin secretion in goldfish显示文摘 | Jobin R M Van Goor F Neumann C M | | 0，，： | 1 |
| 11 | Perioperative intra- venous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery显示文摘 | Kopper W Weigand M Neumann F | 2004 | Anesth Analg2004，98，： | 1 |
| 12 | Proc(xagulantin inflammatory responds of monocytes after direct balloon angioplasty in acute myocar- dial infarction显示文摘 | Ott I Neumann F J Kenngott S | 2008 | Am J Cardlol2008，82，8： | 1 |
| 13 | Structural and functional properties of ribosomal protein L7 fromhumans and rodents显示文摘 | HEMMERICH P VON MIKECZ A NEUMANN F | 1993 | Nucleic Acids Res1993，21，2： | 1 |
| 14 | Synthetic 6-glucosyl phospholipid as a drug transport system 显示文摘 | Guerra F I Neumann J M Huynb-Dinh T | 1987 | Tetrahedron Lett1987，28，31： | 1 |
| 15 | A novel mechanism of Silicon uptake显示文摘 | NEUMANN D DE F C | 2002 | Protoplasma2002，220，12： | 1 |
| 16 | Noninvasive monitoring using serum amyloid A and serum neopterin in cardiac transplantation 显示文摘 | Muller T F Vogl M Neumann M C | 1998 | Clin Chim Acta1998，276，1： | 1 |
| 17 | Association between mycophenolic acid 12-h trough levels and clinical endpoints inpatients with autoimmune disease on mycophenolatemofetil显示文摘 | NEUMANN I FUHRMANN H FANG I F | 2008 | Nephrol Dial Transplant2008，23，11： | 1 |
| 18 | Abeiximab and heparin versus bivalirudin for non-ST-elevation myocardial in-farction 显示文摘 | Kastrati A Neumann F J Schulz S | 2011 | N Engl J Med2011，365，21： | 1 |
| 19 | Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation 显示文摘 | NEUMANN S BRADKE F TESSIER LAVIGNE M | 2002 | Neuron2002，34，： | 1 |
| 20 | Diffusion-and perfusion-weighted MRI The DWI/PWI mismatch region in acute stroke显示文摘 | Neumann Haefelin T Wittsack HJ Wenserski F | | 0，，： | 1 |
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