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| 1 | Neurotrophins role in depression neurobiology:a review of basic and clinical ev-idence显示文摘 | Neto FL Borges G Torres-Sanchez S | 2011 | Curr Neuropharmacol2011，9，4： | 1 |
| 2 | Lung ultrasound in critically ill patients:a new diagnostic tool显示文摘 | Dexheimer Neto FL Dalcin Pde TjTeixeira C | 2012 | J Bras Pneumol2012，38，2： | 1 |
| 3 | Neurotrophins role in depression neurobiology:a review of basic and clinical evidence显示文摘 | Neto FL Borges G Torres-Sanchez S | 2011 | Curr Neuropharmacol2011，9，4： | 1 |
| 4 | Experiment nonunion in dogs显示文摘 | Dos S Neto FL Volpon JB | 1984 | Clin Orthop Rel Res1984，187，： | 1 |
| 5 | Xylo-oligosaccharides from lignocellulosic materials: Chemical structure, health benefits and production by chemical and enzymatic hydrolysis显示文摘 | Ana Flávia Azevedo Carvalho Pedro de Oliva Neto Douglas Fernandes da Silva Gláucia Maria Pastore | 2013 | Food Research International2013，，1： | 1 |
| 6 | Cytokine profiles in women with different subtypes of major depressive disorder显示文摘 | Marques--Deak AH Neto FL Dominguez WV | 2005 | J Psyehiatr Res2005，12，： | 1 |
| 7 | Neurotrophins role in depression neurobiology: a review of basic and clinical evidence 显示文摘 | Neto FL Borges G Torres-Sanchez S | 2011 | Curr Neuropharmaco12011，9，： | 1 |
| 8 | Immunoexpression of inhibitors of apoptosis proteins and their antagonistSMAC/DIABLO in colorectal carcinoma: Correlation with apoptotic index, cellularproliferation and prognosis显示文摘 | Flávio De Oliveira Lima Henrique De Oliveira Costa Luis Barrezueta Celina Fujiyama Oshima José Silva Thiago Gomes Nathanael Pinheiro Ricardo Neto Marcello Franco | 2009 | Oncology Reports2009，，2： | 1 |
| 9 | Experiment nonunion in dogs显示文摘 | Dos Sant OS Neto FL Volpon JB | 1984 | Clin Orthop Rel Res1984，187，： | 1 |
| 10 | Experiment nonunion in dogs显示文摘 | Dos Santos Neto FL Volpon JB | 1984 | Clin Orthop Rel Res1984，187，： | 1 |
| 11 | Out-of-bed extubation: a feasibility study显示文摘 | Dexheimer Neto FL Vesz PS Cremonese RV | 2014 | Rev Bras Ter Intensiva2014，26，3： | 1 |
| 12 | Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer显示文摘 | Belmiro Parada Flávio Reis Raquel Cerejo Patrícia Garrido José Sereno Maria Xavier-Cunha Paula Neto Alfredo Mota Arnaldo Figueiredo Frederico Teixeira Achille Cittadini | 2013 | BioMed Research International2013，，： | 1 |
| 13 | Lung ultrasound in critically ill patients:a new diagnostic tool显示文摘 | Dexheimer Neto FL Dalcin Pde T Teixeira C | | 0，，02： | 1 |
| 14 | Lung ultrasound in critically ill patients:a new diagnostic tool显示文摘 | Dexheimer Neto FL Dalcin Pde T Teixeira C | | 0，，： | 1 |
| 15 | Immunoexpression of inhibitors of apoptosis proteins and their antagonistSMAC/DIABLO in colorectal carcinoma: Correlation with apoptotic index, cellularproliferation and prognosis显示文摘 | Flávio De Oliveira Lima Henrique De Oliveira Costa Luis Barrezueta Celina Fujiyama Oshima José Silva Thiago Gomes Nathanael Pinheiro Ricardo Neto Marcello Franco | 2009 | Oncology Reports2009，，2： | 1 |
| 16 | Can gadoxetic acid–enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major cause of liver disease worldwide.The diagnosis of nonalcoholic steatohepatitis(NASH),the most severe form of NAFLD,is crucial and has prognostic and therapeutic implications.However,currently this diagnosis is based on liver biopsy and has several limitations.AIM To evaluate the performance of gadoxetic acid–enhanced magnetic resonance imaging(GA-MRI)in differentiating isolated steatosis from NASH in patients with NAFLD.METHODS In this prospective study,56 patients with NAFLD(18 with isolated steatosis and 38 with NASH)underwent GA-MRI.The contrast enhancement index(CEI)was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA administration.Between-group differences in mean CEI were examined using Student's t test.The area under the receiver operator characteristic curve and the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging were evaluated.RESULTS The mean CEI for all subjects was 1.82±0.19.The mean CEI was significantly lower in patients with NASH than in those with isolated steatosis(P=0.008).Two CEI cut-off points were used:<1.66(94%specificity)to characterize NASH and>2.00(89%sensitivity)to characterize isolated steatosis.CEI values between 1.66 and 2.00 indicated liver biopsy,and the procedure could be avoided in 40%of patients with NAFLD.CONCLUSION GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis,and could help to avoid liver biopsy in patients with NAFLD. | Viviane Brandão Amorim Daniella Braz Parente Fernando Fernandes Paiva Jaime Araújo Oliveira Neto Amanda Almeida Miranda Cláudia Cravo Moreira Flávia Ferreira Fernandes Carlos Frederico FerreiraCampos Nathalie Carvalho Leite Renata de Mello Perez Rosana Souza Rodrigues | 2020 | World Journal of Hepatology2020，12，9： | 0 |
| 17 | In vitro induced pluripotency from urine-derived cells in porcine显示文摘BACKGROUND The generation of induced pluripotent stem cells(iPSC)has been a game-changer in translational and regenerative medicine;however,their large-scale applicability is still hampered by the scarcity of accessible,safe,and reproducible protocols.The porcine model is a large biomedical model that enables translational applications,including gene editing,long term in vivo and offspring analysis;therefore,suitable for both medicine and animal production.AIM To reprogramme in vitro into pluripotency,and herein urine-derived cells(UDCs)were isolated from porcine urine.METHODS The UDCs were reprogrammed in vitro using human or murine octamer-binding transcription factor 4(OCT4),SRY-box2(SOX2),Kruppel-like factor 4(KLF4),and C-MYC,and cultured with basic fibroblast growth factor(bFGF)supplementation.To characterize the putative porcine iPSCs three clonal lineages were submitted to immunocytochemistry for alkaline phosphatase(AP),OCT4,SOX2,NANOG,TRA181 and SSEA 1 detection.Endogenous transcripts related to the pluripotency(OCT4,SOX2 and NANOG)were analyzed via reverse transcription quantitative realtime polymerase chain reaction in different time points during the culture,and all three lineages formed embryoid bodies(EBs)when cultured in suspension without bFGF supplementation.RESULTS The UDCs were isolated from swine urine samples and when at passage 2 submitted to in vitro reprogramming.Colonies of putative iPSCs were obtained only from UDCs transduced with the murine factors(mOSKM),but not from human factors(hOSKM).Three clonal lineages were isolated and further cultured for at least 28 passages,all the lineages were positive for AP detection,the OCT4,SOX2,NANOG markers,albeit the immunocytochemical analysis also revealed heterogeneous phenotypic profiles among lineages and passages for NANOG and SSEA1,similar results were observed in the abundance of the endogenous transcripts related to pluripotent state.All the clonal lineages when cultured in suspension without bFGF were able to form EBs expressing ectoderm and mesoderm layers transcripts.CONCLUSION For the first time UDCs were isolated in the swine model and reprogrammed into a pluripotentlike state,enabling new numerous applications in both human or veterinary regenerative medicine. | Kaiana Recchia Lucas Simões Machado Ramon Cesar Botigelli Naira Caroline Godoy Pieri Gabriela Barbosa Raquel Vasconcelos Guimarães de Castro Mariana Groke Marques Laís Vicari de Figueiredo Pessôa Paulo Fantinato Neto Flávio Vieira Meirelles Aline Fernanda de Souza Simone Maria Massami Kitamura Martins Fabiana Fernandes Bressan | 2022 | World Journal of Stem Cells2022，14，3： | 0 |
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