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153篇 您的检索式:作者名="Cittadini"
    题名 作者 年代 出处 被引量
1Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives显示文摘Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies.A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the development of novel,more powerful therapies.The traditional,so-called'stochastic model'of tumor development,which assumes that each cancer cell is tumorigenic,has been deeply challenged during the past decade by the identification of cancer stem cells(CSCs),a biologically distinct subset of cells within the bulk of tumor mass.This discovery led to the development of the hierarchical model of tumorigenesis which assumes that only CSCs have the ability to initiate tumor growth,both at primary and metastatic sites.This model implies that the elimination of all CSCs is fundamental to eradicate tumors and that failure to do so might be responsible for the occurrence of relapses and/or metastases frequently observed in the clinical management of colorectal cancer patients.Identification and isolation of CSCs is essential for a better understanding of their role in the tumorigenetic process and for the development of CSC-specific therapies.Several methods have been used for this purpose and many efforts have been focused on the identification of specific CSC-surface markers.This review provides an overview of the proposed roles of CSC in human colorectal tumorigenesis focusing on the most important molecules identified as CSC-specific markers in colorectal cancer and on the potential strategies for the development of CSC-targeted therapy.Caterina Fanali Donatella Lucchetti Marisa Farina Maddalena Corbi Valerio Cufino Achille Cittadini Alessandro Sgambato 2014World Journal of Gastroenterology2014,20,4:7
2Multiple functions of p27(Kip1) and its alterations in tumor cells:a review显示文摘Sgambato A Cittadini A Faraglia B 2000J Cell Physiol2000,183,1:2
3Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocadial infarction显示文摘 Grossman JD Napoli R 1997JACC1997,29,5:1
4Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally ad-vanced cervical cancer显示文摘Sala P MarchiolèP Cittadini G 0,,:1
5Multiple functions of p27Kip1 and its alterations in tumor cells显示文摘Sgambato AA Cittadini A Weinstein IB 2000J Cell Physiol2000,183,1:1
6Role of ultrasonography in the staging of gastrointestinal neoplasms 显示文摘Neumaier CE Cittadini G Grasso A 2001Semin Surg Oneol2001,20,2:1
7Static electromagnetic fields generated by corrosion currents inhibit human osteoblast differentiation显示文摘Denaro V Cittadini A Bamaba SA 2008Spine (Phila Pa 1976)2008,33,9:1
8An ultrastructural study of calcium induced degenerative change in dissociated heart cells显示文摘Russo MA Cittadini A Dani AM 1981J Mol Cell Cardiol1981,13,:1
9Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshoht in experimental heart failure 显示文摘Cittadini A Monli MG Isgaard J ct al 2003Cardiovasc Res2003,58,:1
10Capillary zone electrophoresis of potassium in human vitreous humour:validation of a new method显示文摘Tagliaro F Manetto G Cittadini F 1999J Chromatogr B Biomed Sci Appl1999,733,1:1
11Multiple functions of p27(Kip1)and its alterations in tumor cells:a review显示文摘Sgambato A Cittadini A Faraglia B 2000J Cell Physiol2000,183,1:1
12Growth hormone and the heart显示文摘Sacca L Cittadini A Fazio S 1994Endocr Rev1994,15,5:1
13Magnesium in cell proliferation and differentiation显示文摘Wolf FI Cittadini A 1999Front Biosci1999,4,:1
14Cardiovascular effects of short-term growth hormone hypersecretion显示文摘Fazio S Cittadini A Biondi B 2000J Clin Ecdocrinol Metab2000,85,1:1
15Evidence for biventricular in volvementin a cromegaly:a doppler echocar-diographic study显示文摘Fazio S Cittadini A Sabatini D Eur Heart J0,14,:1
16Inorganic byproducts in waters disinfected with chlorine dioxide 显示文摘Veschetti E Cittadini B Maresca D 2005Microchem J2005,79,12:1
17Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo显示文摘Bonci D Cittadini A Latronico MY 2003Gene Ther2003,10,:1
18Cardiovascular effects of short-term growth hormone hypersecretion显示文摘Fazio S Cittadini A Biondi B 2000J Clin Endocrinol Metab2000,85,1:1
19Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles显示文摘Cittadini A Ishiguro Y Stromer H 1998Circ Res1998,83,:1
20Cardiovascular effects of short-term growth hormone hypersecretion显示文摘Fazio S Cittadini A Biondi B 2000J Clin Ecdocrinol Metab2000,85,1:1
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