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| 1 | Enhanced Vitamin C Production Mediated by an ABA-Induced PTP-like Nucleotidase Improves Plant Drought Tolerance in Arabidopsis and Maize显示文摘Abscisic acid(ABA)is a key phytohormone that mediates environmental stress responses.Vitamin C,or L-ascorbic acid(AsA),is the most abundant antioxidant protecting against stress damage in plants.How the ABA and AsA signaling pathways interact in stress responses remains elusive.In this study,we characterized the role of a previously unidentified gene,PTPN(PTP-like Nucleotidase)in plant drought tolerance.In Arabidopsis,(AtPTPN was expressed in multiple tissues and upregulated by ABA and drought treatments.Loss-of-function mutants oiAtPTPN were hyposensitive to ABA but hypersensitive to drought stresses,whereas plants with enhanced expression AtPTPN showed opposite phenotypes to.Overexpression of maize PTPN(ZmPTPN)promoted,while knockdown oiZmPTPN inhibited plant drought tolerance,indicating conserved and positive roles of PTPN in plant drought tolerance.We found that both AtPTPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP,and that AtPTPN positively regulated AsA production via endogenous Pi content control.Consistently,overexpression of VTC2,the rate-limiting synthetic enzyme in AsA biosynthesis,promoted AsA production and plant drought tolerance,and these effects were largely dependent on AtPTPN activity.Furthermore,we demonstrated that the heat shock transcription factor HSFA6a directly binds the AtPTPN promoter and activates AtPTPN expression.Genetic analyses showed that AtPTPN is required for HSFA6a to regulate ABA and drought responses.Taken together,our data indicate that PTPN-mediated crosstalk between the ABA signaling and AsA biosynthesis pathways positively controls plant drought tolerance. | Hui Zhang Yanli Xiang Neng He Xiangguo Liu Hongbo Liu Liping Fang Fei Zhang Xiaopeng Sun Delin Zhang Xingwang Li William Terzaghi Jianbing Yan Mingqiu Dai | 2020 | Molecular Plant2020，13，5： | 7 |
| 2 | Research Progress of Refractory High Entropy Alloys:A Review显示文摘Owing to superior comprehensive performance than conventional superalloys at high temperature,refractory high entropy alloy(RHEA)is becoming a promising candidate for the next generation high-temperature material.Herein,contemporary aspects of corresponding development of RHEAs are reviewed to discuss various factors affecting the organization structure and service performance.It mainly covers alloying system and strengthening mechanism,the preparation method,plastic deformation and the related mechanism,as well as microstructure control by heat treatment.Firstly,the alloy systems and strengthening mechanism are introduced.This is followed by different preparation methods and the comparison of strengths and shortcomings based on different RHEAs.Then,hot deformation behavior and plastic deformation under different loadings are analyzed.Based on this,the influence of heat treatment on microstructures prior to and after the deformation is further summarized.Finally,some important research areas to be carried out in future are pointed out.This review will give a deep understanding of the effects of different factors on the service performance and provide scientific guide in designing RHEAs with improved performance. | Xiaochang Xie Neng Li Wei Liu Shuai Huang Xiaoyong He Qiuying Yu Huaping Xiong Enhui Wang Xinmei Hou | 2022 | Chinese Journal of Mechanical Engineering2022，35，6： | 4 |
| 3 | New Dopamine Derivative from Lycium Barbarum显示文摘A new dopamine derivative, lyciumide A, was isolated from the fruits of Lyciumbarbarum. Its structure was elucidated as p-methoxy-cis-cinnamoyl dopamine by spectral methods. | Cheng ZOU Qing ZHAO Chang Xiang CHEN Yi Neng HE(Faculty of Pharmacy, Kunming Medical College, Kunming 650031)(Yunnan College of Traditional Chinese Medicine, Kunming 650200)(Laboratory of Phytochemistry, Kunming Institute of Botany, the Chinese Academy | 1999 | Chinese Chemical Letters1999，10，2： | 3 |
| 4 | Accumulated Clinical Experiences from Successful Treatment of 1377 Severe and Critically Ill COVID-19 Cases显示文摘Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of China.The West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill cases.The treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world. | Yong GAO Hai-bo QIU Shu ZHOU Zhen-ning WANG Jian-chu ZHANG Zheng-liang ZHANG Zhao-xin QIAN Hong-bo WANG Shi-huan YU Yi-feng LUO Ya dan WANG Zhuang LIU Wei-ci WANG Ming JIA Li-ming ZHANG Yu ZHANG Yang JIN Yong ZHANG Yong LIU Zi-hua ZHOU Ying SU Hui-qing LI Wei-min XIAO Kai HUANG Ping HE Gang LI Zhao-hui FU Shi LIU Neng xing LIN Fan-jun CHENG | 2020 | Current Medical Science2020，40，4： | 2 |
| 5 | Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid–blood barrier显示文摘 | Wenjing Zhang Min Dai Anders Fridberger Ahmed Hassan Jacqueline DeGagne Lingling Neng Fei Zhang Wenxuan He Tianying Ren Dennis Trune Manfred Auer Xiaorui Shi | 2012 | Proceedings of the National Academy of Sciences2012，，26： | 2 |
| 6 | An efficient GPU-based parallel tabu search algorithm for hardware/software co-design显示文摘Hardware/software partitioning is an essential step in hardware/software co-design.For large size problems,it is difficult to consider both solution quality and time.This paper presents an efficient GPU-based parallel tabu search algorithm(GPTS)for HW/SW partitioning.A single GPU kernel of compacting neighborhood is proposed to reduce the amount of GPU global memory accesses theoretically.A kernel fusion strategy is further proposed to reduce the amount of GPU global memory accesses of GPTS.To further minimize the transfer overhead of GPTS between CPU and GPU,an optimized transfer strategy for GPU-based tabu evaluation is proposed,which considers that all the candidates do not satisfy the given constraint.Experiments show that GPTS outperforms state-of-the-art work of tabu search and is competitive with other methods for HW/SW partitioning.The proposed parallelization is significant when considering the ordinary GPU platform. | Neng Hou Fazhi He Yi Zhou Yilin Chen | 2020 | Frontiers of Computer Science2020，14，5： | 2 |
| 7 | Krüppel-like factor 4 negatively regulates β-catenin expression andinhibits the proliferation, invasion and metastasis of gastric cancer显示文摘 | Neng Zhang Jun Zhang Leiyuan Shuai Lang Zha Miao He Zhen Huang Ziwei Wang | 2012 | International Journal of Oncology2012，，6： | 1 |
| 8 | Tartaric acid-assisted co-precipitation synthesis of Er^(3+)-doped Lu_2O_3 nanopowders显示文摘Erbium-doped lutetia nanopowders were synthesized by a novel co-precipitation method using tartaric acid as precipitant.The properties of the samples were investigated by Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),TG-DSC, field emission scanning electron microscopy(FE-SEM),and upconversion luminescence analysis.Pure cubic Lu_2O_3 nanopowders were directly obtained when the precursor was calcined at 800℃for 2 h,the samples showed strong upconversion luminescence under excitation of 980 nm laser diode. | Neng Li Wang Xi Yan Zhang Peng He Wang | 2012 | Chinese Chemical Letters2012，23，11： | 1 |
| 9 | WSGM-SD: An Approach to RESTful Service Discovery Based on Weighted Service Goal Model显示文摘Faced with the rapidly increasing Web services, it becomes a challenging issue for users to effectively and accurately discover and reuse services. Existing service discovery approaches are mainly developed for services with WSDL documents, while only a few attention is being paid to services described in natural language,especially to the RESTful services. Towards this issue, we introduce a Weighted service goal model(WSGM) by measuring the weights of service goals extracted from the textual descriptions of services. Based on the WSGM, a novel service discovery approach called Service discovery based on WSGM(WSGM-SD) is proposed. Experiments on Programmable Web, a public Web service repository, demonstrate the effectiveness of the proposed approach. | ZHANG Neng HE Keqing WANG Jian LI Zheng | 2016 | Chinese Journal of Electronics2016，25，2： | 0 |
| 10 | Research on the Revitalization of Rural Talents under the Strategy of Rural Revitalization显示文摘Since the implementation of the rural revitalization strategy,it has provided multiple assistance for the development of the vast number of villages in China.Talents are the key to the revitalization and development of the countryside.Only when a large number of high-quality talents take root in the countryside and help the rural construction in different fields can we give full play to the role of talents in promoting rural development.This paper takes the rural areas of China as the research object,analyzes the current situation of the development of rural talents,discusses the problems existing in the development of rural human resources,and puts forward effective measures for the revitalization of rural talents,to provide a solid theoretical basis for the better development of the countryside. | Xinsheng LI Minghua GU Neng CHEN Yongxian LIU Mengling NONG Yimiao LI Ya ZHANG Qijun WEN Yilin WANG Wei LIU Lishan HE | 2021 | Asian Agricultural Research2021，13，6： | 0 |
| 11 | Anomalous-plasmoid-ejection-induced secondary magnetic reconnection: modeling solar flares and coronal mass ejections by laser–plasma experiments显示文摘The driving mechanism of solar flares and coronal mass ejections is a topic of ongoing debate, apart from the consensus that magnetic reconnection plays a key role during the impulsive process. While present solar research mostly depends on observations and theoretical models, laboratory experiments based on high-energy density facilities provide the third method for quantitatively comparing astrophysical observations and models with data achieved in experimental settings.In this article, we show laboratory modeling of solar flares and coronal mass ejections by constructing the magnetic reconnection system with two mutually approaching laser-produced plasmas circumfused of self-generated megagauss magnetic fields. Due to the Euler similarity between the laboratory and solar plasma systems, the present experiments demonstrate the morphological reproduction of flares and coronal mass ejections in solar observations in a scaled sense,and confirm the theory and model predictions about the current-sheet-born anomalous plasmoid as the initial stage of coronal mass ejections, and the behavior of moving-away plasmoid stretching the primary reconnected field lines into a secondary current sheet conjoined with two bright ridges identified as solar flares. | Quanli Dong Dawei Yuan Shoujun Wang Xun Liu Yutong Li Xiaoxuan Lin Huigang Wei Jiayong Zhong Shaoen Jiang Yongkun Ding Bobin Jiang Kai Du Yongjian Tang Mingyang Yu Xiantu He Neng Hua Zhanfeng Qiao Kuixi Huang Ming Chen Jianqiang Zhu Gang Zhao Zhengming Sheng Jie Zhang | 2013 | High Power Laser Science and Engineering2013，1，1： | 0 |
| 12 | How should congenital absence of cruciate ligaments be treated? A case report and literature review显示文摘BACKGROUND Hypoplasia of bilateral cruciate ligaments is a rare congenital malformation.The diagnosis of such diseases and indications for the various treatment options require further analysis and discussion.CASE SUMMARY The patient is a 26-year-old Chinese woman who has been suffering from knee pain since the age of 8 years,2-3 episodes a year.Three years ago,due to the practice of advanced yoga poses,the frequency of left knee pain increased,requiring prompt medical treatment.Magnetic resonance imaging demonstrated an absence of both anterior and posterior cruciate ligaments of both knees with abnormal posterior tilting of the tibial plateau.Bilateral subluxation of the knee joint was also found,therefore tibial osteotomy was performed.The patient reported at the 24 mo follow-up that the frequency of pain and instability had been reduced and function restored.CONCLUSION Osteotomy may be an effective method to treat patients with congenital cruciate ligament deficiency with posterior tibial plateau tilting.The diagnosis of congenital cruciate ligament deficiency shall be based on the combination of patient’s medical history,clinical manifestations,and findings from imaging to avoid possible misdiagnosis.Based on the symptoms,frequency of attacks,and intent of the individual,appropriate treatment options shall be identified. | Ran Lu Dong-Ping Zhu Neng Chen He Sun Ze-Hui Li Xue-Wei Cao | 2019 | World Journal of Clinical Cases2019，7，19： | 0 |
| 13 | Pulmonary Nodules Developed Rapidly in Staffs in the Isolation Ward of a Chinese Hospital during the COVID-19 Epidemic显示文摘In December 2019,the novel 2019 coronavirus disease(COVID-19)emerged in Wuhan and spread all over the country.The Zibo Central Hospital had set up a febrile clinic and isolation ward for confirmed and suspected patients since January 23,2020.Suspected patients were hospitalized immediately to the isolation ward.Every healthcare staff was authorized to undergo low-dose computed tomography(LDCT)of the chest free of charge before and after their assignment in the isolation ward. | LI Yu Hua YU Ke Wen SUN Neng Jun JIN Xiao Dong LUO Xin YANG Jing HE Bing LI Bo | 2020 | Biomedical and Environmental Sciences2020，33，12： | 0 |
| 14 | An enhanced GPU reduction at the warp-level显示文摘In recent years, graphical processing unit(GPU)-accelerated intelligent algorithms have been widely utilized for solving combination optimization problems, which are NP-hard. These intelligent algorithms involves a common operation, namely reduction, in which the best suitable candidate solution in the neighborhood is selected. As one of the main procedures, it is necessary to optimize the reduction on the GPU. In this paper, we propose an enhanced warp-based reduction on the GPU. Compared with existing block-based reduction methods, our method exploit efficiently the potential of implementation at warp level, which better matches the characteristics of current GPU architecture. Firstly, in order to improve the global memory access performance, the vectoring accessing is utilized. Secondly, at the level of thread block reduction, an enhanced warp-based reduction on the shared memory are presented to form partial results. Thirdly, for the configuration of the number of thread blocks, the number of thread blocks can be obtained by maximizing the size of thread block and the maximum size of threads per stream multi-processor on GPU. Finally, the proposed method is evaluated on three generations of NVIDIA GPUs with the better performances than previous methods. | Hou Neng He Fazhi Zhou Yi | 2016 | Computer Aided Drafting,Design and Manufacturing2016，26，2： | 0 |
| 15 | Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing显示文摘The common marmoset(Callithrix jacchus)has emerged as a valuable nonhuman primate model in biomedical research with the recent release of high-quality reference genome assemblies.Epileptic marmosets have been independently reported in two Asian primate research centers.Nevertheless,the population genetics within these primate centers and the specific genetic variants associated with epilepsy in marmosets have not yet been elucidated.Here,we characterized the genetic relationships and risk variants for epilepsy in 41 samples from two epileptic marmoset pedigrees using whole-genome sequencing.We identified 14558184 single nucleotide polymorphisms(SNPs)from the 41 samples and found higher chimerism levels in blood samples than in fingernail samples.Genetic analysis showed fourth-degree of relatedness among marmosets at the primate centers.In addition,SNP and copy number variation(CNV)analyses suggested that the WW domain-containing oxidoreductase(WWOX)and Tyrosine-protein phosphatase nonreceptor type 21(PTPN21)genes may be associated with epilepsy in marmosets.Notably,KCTD18-like gene deletion was more common in epileptic marmosets than control marmosets.This study provides valuable population genomic resources for marmosets in two Asian primate centers.Genetic analyses identified a reasonable breeding strategy for genetic diversity maintenance in the two centers,while the case-control study revealed potential risk genes/variants associated with epilepsy in marmosets. | Xiangyu Yang Yafei Mao Xuan-Kai Wang Dong-Ni Ma Zhen Xu Neng Gong Barbara Henning Xu Zhang Guang He Yong-Yong Shi Evan EEichler Zhi-Qiang Li Eiki Takahashi Wei-Dong Li | 2023 | Zoological Research2023，44，5： | 0 |
| 16 | Three New Styrylpyroncs from Goniothalamus leiocarpus显示文摘Three new styrylpyrones. named 7-epi-goniodiol 1. leiocarpin B 2 and leiocarpin C 3.were isolated from the stem barks of Goniothalamus leiocarpus. Their structures were elucidated bymeans of spectral and chemical methods. The relative configuration of 1 and 2 were determined byX-ray crystallographic analysis. | Qing MU Chao Ming LI Yi Neng HE Han Dong SUN Hui Lan ZHENG Yang LU Qi Tai ZHENG Nan WU Ren Wang JIANG(Phytochemistry Laboratory, Kunming Institute of Botany, the Chinese Acadmy of Sciences,Kunming 650204)(Institute of Meteria Medica. Chinese Academ | 1999 | Chinese Chemical Letters1999，10，2： | 0 |
| 17 | A New Triterpenoid Saponin: Se-saponin A显示文摘A new triterpenoid saponin, se-saponin A, was isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Its structure was determined by spectral and chemical methods. Only one triterpenoid saponin has been isolated from Clerodendrum genus before. Se-saponin A is the second instance. | Hui YANG~(1,2) Qin MU~1 Yi Neng HE~1 Han Dong SUN~1 (1Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences. Kunming 650204 (2Chemistry Department, College of Life Science and Chemistry, Yunnan University, Kunming 650091) | 2000 | Chinese Chemical Letters2000，11，4： | 0 |
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