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| 1 | Progress in additive manufacturing on new materials: A review显示文摘Recent efforts and advances in additive manufacturing(AM) on different types of new materials are presented and reviewed. Special attention is paid to the material design of cladding layers, the choice of feedstock materials, the metallurgical behavior and synthesis principle during the AM process, and the resulted microstructures and properties, as well as the relationship between these factors. Thereafter,the trend of development in the future is forecasted, including: Effects of the particles size and size distribution of powders; Approaches for producing fine microstructures; Opportunities for creating new materials by AM; Wide applications in reconditioning of damaged components; Challenges for deep understanding and applications of the AMed new materials. The idea of 'Develop Materials' or 'Create Materials' by AM is highlighted, but a series of scientific, technological and engineering problems remain to be solved in future. | Neng Li Shuai Huang Guodong Zhang Renyao Qin Wei Liu Huaping Xiong Gongqi Shi Jon Blackburn | 2019 | Journal of Materials Science & Technology2019，35，2： | 47 |
| 2 | CMIP6和CMIP5模式对中国极端温度的模拟能力的评估显示文摘本文评估了CMIP5和CMIP6模式对中国在1979-2005年期间的极端温度的模拟性能。结果表明:CMIP6模式可以很好地再现年最大日最高气温,年最小日最低气温和霜冻日数的空间分布特征。对于年最大日最高气温,持续暖日日数和暖昼,CMIP6模式间的不确定性相对于CMIP5模式有所降低。并且,CMIP6模式也能表现出观测到的极端温度的趋势。然而,CMIP6模式再现暖昼和冷夜的能力仍然不足,特别是在青藏高原上存在明显的冷偏差或者暖偏差对于某些指数。单个CMIP6或CMIP5模式的模拟能力就不同的指数而有所不同,某些模式的模拟能力较为突出。对于一些来自同一机构不同版本的模式,改进的CMIP6模式与CMIP5模式的模拟结果没有明显差异。多模式中位数平均的模拟效果优于大多数单个模式。 | LUO Neng GUO Yan GAO Zhibo CHEN Kexin CHOU Jieming | 2020 | Atmospheric and Oceanic Science Letters2020，13，6： | 15 |
| 3 | Congenital expression of mdr-1 gene in tissues of carcinoma and its relation with patho morphology and prognosis显示文摘NTRODUCTIONMultidrugresistance(MDR)ofmalignanttumorcelhasarousedwidespreadinterest.IthasbeenshownthatMDRispresentinmanymalign... | ZHANG Li Jian 1, CHEN Ke Neng 1, XU Guang Wei 1, XING Hai Ping 2 and SHI Xiao Tian 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 15 |
| 4 | Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma显示文摘Background: Percutaneous radiofrequency ablation(RFA) is a first?line treatment for very?early?stage hepatocellular carcinoma(HCC), whereas the efficacy of percutaneous microwave ablation(MWA) for very?early?stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very?early?stage HCC.Methods: Clinical data of 460 patients who were diagnosed with very?early?stage HCC and treated with percutane?ous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Mili?tary Medical University, in Shanghai, China were retrospectively analyzed. Of these 460 patients, 159 received RFA, 301 received MWA. Overall survival(OS), recurrence?free survival(RFS), local tumor progression(LTP), complete ablation, and complication occurrence rates were compared between the two groups, and the prognostic factors associated with survival were analyzed.Results: No significant differences were observed between the two groups in terms of the 1?, 3?, or 5?year OS rates(99.3%, 90.4%, and 78.3% for MWA vs. 98.7%, 86.8%, and 73.3% for RFA, respectively; P = 0.331). Furthermore, no signif?icant differences were observed between the two groups in terms of the corresponding RFS rates(94.4%, 71.8%, and 46.9% for MWA vs. 89.9%, 67.3%, and 54.9% for RFA, respectively; P ete ablation rates(98.3% vs. 98.1%, P = 0.309), the LTP rates(9.6% vs. 10.1%, P = 0.883), the compl multivariate analysis, LTP, an= 0.860), or the occurrence rates of major complications(0.7% vs. 0.6%, P = 0.691). Bytiviral therapy, and treatment of recurrence were independent risk fac?tors for OS(P < 0.001), and the alpha?fetoprotein level was an independent prognostic factor for RFS(P = 0.002).Conclusions: MWA is as safe and effective as RFA in treating very?early?stage HCC, supporting MWA as a first?line treatment option for this disease. | Yun Xu Qiang Shen Neng Wang Pan-Pan Wu Bin Huang Ming Kuang Guo-Jun Qian | 2017 | Chinese Journal of Cancer2017，36，5： | 15 |
| 5 | NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro显示文摘 | Wen-juan WANG Lin-mei LONG Neng YANG Qing-qing ZHANG Wen-jun JI Jiang-hu ZHAO Zheng-hong QIN ZhongWANG Gang CHEN Zhong-qin LIANG | 2013 | Acta Pharmacologica Sinica2013，34，5： | 14 |
| 6 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 7 | Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells显示文摘INTRODUCTIONThe treatment of human epithelial malignancies islimited by drug resistance and toxic and side effects,which results in the failure in the treatment ofmajority of advanced cancer victims.To seek for anew,and specific antineoplastic therapy willprovide hope for tumor treatment.Althoughdisordered intermediary metabolism in cancer cellshas been known for many years,much of the | Pei Lin Huang Shi Neng Zhu Shi Lun Lu Zhen Sheng Dai Yue Lin Jin | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 8 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 9 | Unravelling charge carrier dynamics in protonated g-C3N4 interfaced with carbon nanodots as co-catalysts toward enhanced photocatalytic CO2 reduction: A combined experimental and first-principles DFT study显示文摘在这个工作,我们表明了没有金属的 zerodimensional/ 的成功的构造二维的碳 nanodot (CND )-hybridized protonated g-C 3 N 4(pCN )(CND/pCN ) 借助于静电的吸引力的异质接面光催化剂。我们试验性地发现有 4.4 nm 的一条平均直径的 CND 在用电子显微镜学分析的 pCN 的表面上是一致地分布式的。有 3 wt.% 的一个 CND 内容的 CND/pCN-3 样品在可见、模仿的太阳的光下面在 CO 2 光致还原过程显示出最高催化的活动。这个过程导致在可见光的活动的 10 h 被发现是 29.23 和 58.82 摩尔 ? 以后, CH 4 和公司的全部的数量由 CND/pCN-3 光催化剂产生了的 CH 4 和公司的进化 ? 挠潲獳氭湩敫 ? 牧灡敨敮 ?????? ?? 吗?? | Wee-Jun Ong Lutfi Kurnianditia Putri Yoong-Chuen Tan Lling-Lling Tan Neng Li Yun Hau Ng Xiaoming Wen Siang-Piao Chai | 2017 | Nano Research2017，10，5： | 11 |
| 10 | Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma显示文摘Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f,which displays potential anticancer activity.In the present study,we investigated the anticancer effects of celastrol against clear cell renal cell carcinoma(ccRCC)and the underlying mechanisms.Using Cancer Genome Atlas(TCGA)database and genotype-tissue expression(GTEx)database we conducted a bioinformatics analysis,which showed that the mRNA levels of liver-X receptorsα(LXRα)and ATP-binding cassette transporter A1(ABCA1)in ccRCC tissues were significantly lower than those in adjacent normal tissues.This result was confirmed by immunoblotting analysis of 4 ccRCC clinical specimens,which showed that the protein expression of LXRαand ABCA1 was downregulated.Similar results were obtained in a panel of ccRCC cell lines(786-O,A498,SN12C,and OS-RC-2).In 786-O and SN12C cells,treatment with celastrol(0.25–2.0μM)concentration-dependently inhibited the cell proliferation,migration,and invasion as well as the epithelial-mesenchymal transition(EMT)process.Furthermore,we demonstrated that celastrol inhibited the invasion of 786-O cells through reducing lipid accumulation;celastrol concentration-dependently promoted autophagy to reduce lipid storage.Moreover,we revealed that celastrol dramatically activated LXRαsignaling,and degraded lipid droplets by inducing lipophagy in 786-O cells.Finally,celastrol promoted cholesterol efflux from 786-O cells via ABCA1.In high-fat diet-promoted ccRCC cell line 786-O xenograft model,administration of celastrol(0.25,0.5,1.0 mg·kg^(−1)·d^(−1),for 4 weeks,i.p.)dose-dependently inhibited the tumor growth with upregulated LXRαand ABCA1 protein in tumor tissue.In conclusion,this study reveals that celastrol triggers lipophagy in ccRCC by activating LXRα,promotes ABCA1-mediated cholesterol efflux,suppresses EMT progress,and ultimately inhibits cell proliferation,migration,and invasion as well as tumor growth.Thus,our study provides evidence that celastrol can be used as a lipid metabolism-based anticancer therapeutic approach. | Chan-juan Zhang Neng Zhu Jia Long Hong-tao Wu Yu-xiang Wang Bi-yuan Liu Duan-fang Liao Li Qin | 2021 | Acta Pharmacologica Sinica2021，42，9： | 8 |
| 11 | Spatial Pattern Evolution and Casual Analysis of County Level Economy in Changsha-Zhuzhou-Xiangtan Urban Agglomeration, China显示文摘In order to evaluate whether or not the county units′ economy in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan) Urban Agglomeration was growing as expected, this study analyzed the spatial economy pattern at county-level by using the Exploratory Spatial Data Analysis(ESDA) method. In this process, the global Moran′s I and local Getis-Ord G*i indexes were employed to analyze indicators including per capita GDP and three industrials(i.e. primary, secondary and tertiary industry) from 2000 to 2010. The results show that: 1) the county units′ economy in the Chang-Zhu-Tan Urban Agglomeration has exhibited a strong spatial autocorrelation and an accelerated integration trend since 2008(Moran′ s I increased from 0.26 to 0.56); 2) there is a significant difference in economy development between the northern and southern county units in the Chang-Zhu-Tan Urban Agglomeration: the hotspot zone with high economic level was formed among the northern county units whereas the coldspot zone with low economic level was located in the southern areas. This difference was caused primarily by the increasingly prominent economic radiation effect of Changsha ′upheaval′; 3) town density, secondary industry, and the integration policy are the major contributors driving the evolution of the spatial economy pattern in the Chang-Zhu-Tan Urban Agglomeration. | DONG Minghui ZOU Bin PU Qiang WAN Neng YANG Lingbin LUO Yanqing | 2014 | Chinese Geographical Science2014，24，5： | 8 |
| 12 | Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield显示文摘有高 photoluminescent 量收益(PLQY ) 的做 Heteroatom 的碳点(CD ) 最近在化学传感器,光催化, bioimaging,和药交货中由于他们的应用吸引了注意。氮和磷在到在周期表的碳的靠近的最近并且是关键的在生物医学的成像的地里追踪元素。这二个元素改变 CD 的光、电子的性质并且帮助改进他们的 PLQY 的基本理解。这能也在 photoimaging 和 photothermal 治疗导致多功能的用法。然而,源于做 P 的 CD 的合成的大多数 PLQY 当前低于 50% 。这些 CD 在 bioimaging 和药交货的地里限制了实用性。在这研究,一个单个步的、高效率的热水的方法被使用综合氮和磷药的碳点((N, P ) 有有独立排放的多达 53.8% 的 PLQY 的 -CDs) 行为。而且, CD 在一个大 pH 范围上介绍了高 monodispersity,柔韧的刺激无关的光,和稳定性。分光镜的调查显示 PLQY (N, P ) CD 主要由于 P 的增加和氧化表面的钝化效果。优秀荧光性质(N, P ) CD 能被 Hg 2+ 离子有效地并且有选择地熄灭。如此的系统与一短反应时间在 0-900 nM 集中范围显示出线性回答,显示他们为化学和生物学的领域里的应用程序的潜力。 | Quan Xu Bofan Li Yingchun Ye Wei Cai Weijun Li Chuanyao Yang Yusheng Chen Meng Xu Neng Li Xusheng Zheng Jason Street Yan Luo Lulu Cai | 2018 | Nano Research2018，11，7： | 7 |
| 13 | Three-dimensional image of hepatocellular carcinoma under confocal laser scanning microscope显示文摘AIM To investigate the application of confocallaser scanning microscopy(CLSM)in tumorpathology and three-dimensional( 3-D )reconstruction by CLSM in pathologic specimensof hepatocellular carcinoma(HCC).METHODS The 30μm thick sections were cutfrom the paraffin-embedded tissues of HCC,hyperplasia and normal liver,stained with DNAfluorescent probe YOYO-1 iodide and examinedby CLSM to collect optical sections of nuclei and3-D images reconstructed.RESULTS HCC displayed chaotic arrangementof carcinoma cell nuclei,marked pleomorphism,indented and irregular nuclear surface,andirregular and coarse chromatin texture.CONCLUSION The serial optical tomograms ofCLSM can be used to create 3-D reconstruction ofcancer cell nuclei.Such 3-D impressions mightbe helpful or even essential in making anaccurate diagnosis. | Wang Hai Zhang Shi Neng Zhu Shi Lun Lu Ya Lin Huang Peng Zhao | 2000 | World Journal of Gastroenterology2000，6，3： | 7 |
| 14 | Enhanced Vitamin C Production Mediated by an ABA-Induced PTP-like Nucleotidase Improves Plant Drought Tolerance in Arabidopsis and Maize显示文摘Abscisic acid(ABA)is a key phytohormone that mediates environmental stress responses.Vitamin C,or L-ascorbic acid(AsA),is the most abundant antioxidant protecting against stress damage in plants.How the ABA and AsA signaling pathways interact in stress responses remains elusive.In this study,we characterized the role of a previously unidentified gene,PTPN(PTP-like Nucleotidase)in plant drought tolerance.In Arabidopsis,(AtPTPN was expressed in multiple tissues and upregulated by ABA and drought treatments.Loss-of-function mutants oiAtPTPN were hyposensitive to ABA but hypersensitive to drought stresses,whereas plants with enhanced expression AtPTPN showed opposite phenotypes to.Overexpression of maize PTPN(ZmPTPN)promoted,while knockdown oiZmPTPN inhibited plant drought tolerance,indicating conserved and positive roles of PTPN in plant drought tolerance.We found that both AtPTPN and ZmPTPN release Pi by hydrolyzing GDP/GMP/dGMP/IMP/dIMP,and that AtPTPN positively regulated AsA production via endogenous Pi content control.Consistently,overexpression of VTC2,the rate-limiting synthetic enzyme in AsA biosynthesis,promoted AsA production and plant drought tolerance,and these effects were largely dependent on AtPTPN activity.Furthermore,we demonstrated that the heat shock transcription factor HSFA6a directly binds the AtPTPN promoter and activates AtPTPN expression.Genetic analyses showed that AtPTPN is required for HSFA6a to regulate ABA and drought responses.Taken together,our data indicate that PTPN-mediated crosstalk between the ABA signaling and AsA biosynthesis pathways positively controls plant drought tolerance. | Hui Zhang Yanli Xiang Neng He Xiangguo Liu Hongbo Liu Liping Fang Fei Zhang Xiaopeng Sun Delin Zhang Xingwang Li William Terzaghi Jianbing Yan Mingqiu Dai | 2020 | Molecular Plant2020，13，5： | 7 |
| 15 | Red/orange dual-emissive carbon dots for pH sensing and cell imaging显示文摘The dual-emissive N,S co-doped carbon dots (N,S-CDs) with a long emission wavelength were synthesized via solvothermal method.The N,S-CDs possess relatively high photoluminescence (PL) quantum yield (QY) (35.7%) towards near-infrared fluorescent peak up to 648 nm.With the advanced characterization techniques including X-ray photoelectron spectroscopy (XPS),Fourier transform infrared spectroscopy (FTIR),etc.It is found that the doped N,S elements play an important role in the formation of high QY CDs.The N,S-CDs exist distinct pH-sensitive feature with reversible fluorescence in a good linear relationship with pH values in the range of 1.0-13.0.What is more,N,S-CDs can be used as an ultrasensitive Ag+ probe sensor with the resolution up to 0.4 μM.This finding will expand the application of as prepared N,S-CDs in sensing and environmental fields. | Miaoran Zhang Rigu Su Jian Zhong Ling Fei Wei Cai Qingwen Guan Weijun Li Neng Li Yusheng Chen Lulu Cai Quan Xu | 2019 | Nano Research2019，12，4： | 6 |
| 16 | Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in prevention of autoimmune diabetes in non-obese diabetic mice treated with α- galactosylceramide显示文摘 | Weipeng Li Fang Ji Yong Zhang Ying Wang Neng Yang Hailiang Ge Fuqing Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 5 |
| 17 | Microstructure Characteristics and Mechanical Properties of Nb-17Si-23Ti Ternary Alloys Fabricated by In Situ Reaction Laser Melting Deposition显示文摘Fabrication of ternary Nb–17 Si–23 Ti alloys was attempted by in situ reaction laser melting deposition(LMD)with dual powder feeding method from Nb-28 at.% Ti powder mixture and pure Si powder. The microstructures of the asdeposited alloys were examined with scanning electronic microscope, and the phase constituents were analyzed by X-ray energy-dispersive spectrometer and X-ray diffraction. Furthermore, the effect of laser power on microstructure characteristics, microhardness and indentation fracture toughness was also investigated. The in situ reaction LMD process resulted in remarkable refinement of the microstructure. The as-deposited samples mainly consisted of NbSS,metastable(Nb Ti)3 Si and Ti-rich NbSS. With the increase in the laser power from 1000 to 2000 W, the NbSSmorphology changed from discontinuous dendritic to near equiaxed, but the Ti-rich NbSSphase tended to vanish. Furthermore, with the increase in the laser power, the microhardness of as-deposited samples increased from 822 to 951 HV, while the indentation fracture toughness was improved from 12.3 to 14.1 MPa m1/2. The corresponding mechanism is also discussed. | Wei Liu Hua-Ping Xiong Neng Li Shao-Qing Guo Ren-Yao Qin | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，4： | 5 |
| 18 | Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-KB signaling pathway显示文摘 | Neng YANG Pan WANG Wen-juan WANG Yun-zhen SONG Zhong-qin LIANG | 2015 | Acta Pharmacologica Sinica2015，36，3： | 5 |
| 19 | A flow cytometer based protocol for quantitative analysis of bloom-forming cyanobacteria(Microcystis) in lake sediments显示文摘A quantitative protocol for the rapid analysis of Microcystis cells and colonies in lake sediment was developed using a modified flow cytometer,the CytoSense.For cell enumeration,diluted sediment samples containing Microcystis were processed with sonication to disintegrate colonies into single cells.An optimized procedure suggested that 5 mg dw(dry weight)/mL dilution combined with 200 W × 2 min sonication yielded the highest counting efficiency.Under the optimized determination conditions,the quantification limit of this protocol was 3.3×10 4 cells/g dw.For colony analysis,Microcystis were isolated from the sediment by filtration.Colony lengths measured by flow cytometry were similar to those measured by microscopy for the size range of one single cell to almost 400 μm in length.Moreover,the relationship between colony size and cell number was determined for three Microcystis species,including Microcystis flos-aquae,M.aeruginosa and M.wessenbergii.Regression formulas were used to calculate the cell numbers in differentsized colonies.The developed protocol was applied to field sediment samples from Lake Taihu.The results indicated the potential and applicability of flow cytometry as a tool for the rapid analysis of benthic Microcystis.This study provided a new capability for the high frequency monitoring of benthic overwintering and population dynamics of this bloom-forming cyanobacterium. | Quan Zhou Wei Chen Huiyong Zhang Liang Peng Liming Liu Zhiguo Han Neng Wan Lin Li Lirong Song | 2012 | Journal of Environmental Sciences2012，24，9： | 5 |
| 20 | Novel lignans from the stems and leaves of Trachelospermum jasminoides显示文摘5-methoxydibenzylhydroxybutyrolactone lignans 说出 5-methoxytracheloside 和 5-methoxytrachelogenin 的二篇小说从 Trachelospermum jasminoides ( Lindl )的茎和叶子被孤立 Lem ,他们的结构是被决定( 8S , 8S )-8-hydroxy-3, 3 , 4 , 5-tertramethoxylignan-9 , 9-olide-4-O--d-glucopyranoside 并且( 8S , 8S )-4, 8-dihydroxy-3 , 3 , 4 , 5-tertramethoxylignan-9 ,由各种各样的分光镜的分析的 9-olide 。5-Methoxytracheloside 是新混合物, 5-methoxytrachelogenin 第一次从生来的来源被孤立。 | Ling Jing Neng Jiang Yu Yu Shan Li Le Fu Yi Min Zhao | 2011 | Chinese Chemical Letters2011，22，9： | 5 |
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