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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Asorbate and dehydroaseorbate influence cell cycle progression in a tobacco cell suspension显示文摘 | Potters G Nele H Roland J C | 2000 | Plant Physiol2000，11，24： | 1 |
| 3 | Asorbate and dehydroascorbate influence cell cycle progression in a tobacco cell suspension显示文摘 | Potters G Nele H Roland J C Asard H | | 0，，： | 1 |
| 4 | Effect of Tool Wear on Cutting Forces in the Orthogonal Cutting of Unidirectional Glass Fibre--reinforced Plastics 显示文摘 | Caprino G Iorio I D Nele L | 1996 | Composites Part1996，27，： | 1 |
| 5 | Relationship be- tween bacterial community composition and bottom-up versus top- down variables in four eutropbic shallow lakes显示文摘 | Koenraad M Katleen V D G Nele V | 2002 | Appl Environ Microbiol2002，68，10： | 1 |
| 6 | Composition effects on the activity of Cu-Zn O-Al2O3based catalysts for the water gas shift reaction:A statistical approach显示文摘 | Lima A A G Nele M Moreno E L | 1998 | Appl Catal A1998，171，： | 1 |
| 7 | Characterization of bacterial communities in four freshwater lakes difering in nutrient load and food web structure显示文摘 | Katleen V G Tom V Nele V | 2005 | FEMS Microbial Ecology2005，53，： | 1 |
| 8 | Characterization of bacterial communities in four freshwater lakes differing in nutrient load and food web structure 显示文摘 | KATLEEN V G TOM V NELE V | | FEMS Microbial Ecol0，53，： | 1 |
| 9 | Characterization of bacterial communities in four freshwater lakes differing in nutrient load and food web structure显示文摘 | KATLEEN V G TOM V NELE V | | 0，，： | 1 |
| 10 | Composition effects on the actiity of Cu-ZnO-Al2O3 based catalysts for the water gas shift reaction: a statistical approach显示文摘 | Lima A A G Nele M Moreno E L | 1998 | Applied Catalysis A:General1998，171，： | 1 |
| 11 | Dehydroascorbate Influences the Plant Cell Cycle Through a Glutathionereduction Mechanism 显示文摘 | POTTERS G HOREMANS NELE BELLONE S | 2004 | Plant Physiology2004，，134： | 1 |
| 12 | K-ras mutation in colorectal cancer:relations to patient age, sex and tumor location 显示文摘 | Breivik J Neling G I Spurkland A | 1994 | Br J Cancer1994，69，： | 1 |
| 13 | Detection of Legionellae in hospital water samples by quantitative realtime LightCycle PCR显示文摘 | Nele W G Cathrin F R Reinhard M R | 2001 | Appl Environ Microbiol2001，67，9： | 1 |
| 14 | Moisture dynamics of WPC and the impact on fungal testing显示文摘 | Nele D Soetkin G Bulckc J V | 2010 | International Biodeterioration and Biodegradation2010，64，： | 1 |
| 15 | Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples 显示文摘 | NELE G NICKI J E | 2002 | J Agric Food Chem2002，50，： | 1 |
| 16 | Short-term CO 2 and N 2 O emissions and microbial properties of biochar amended sandy loam soils显示文摘 | Nele Ameloot Stefaan De Neve Kanagaratnam Jegajeevagan Güray Yildiz David Buchan Yvonne Nkwain Funkuin Wolter Prins Liesbeth Bouckaert Steven Sleutel | 2013 | Soil Biology and Biochemistry2013，，： | 1 |
| 17 | Buckwheat honey increases serum antioxidant capacity in humans显示文摘 | NELE G WANG X H NICKI J E | 2003 | J Agric Food Chem2003，51，： | 1 |
| 18 | Effect of tool wear on cutting forces in the orthogonal cutting of unidirectional glass fibre reinforced plastics 显示文摘 | Caprino G De Iorio I Nele L | 1996 | Compos Part A1996，27，： | 1 |
| 19 | Different physical treatment modalities for lymphoedema developing after axillary lymph node dissection for breast cancer:A review显示文摘 | NELE D MARUKE VK INGE G | 2010 | Euro- pean Journal of Obstetrics & Gynecology and Reproductive Biol- ogy (2010)149:3-92010，，2010： | 1 |
| 20 | Impaired suppressive capacity of activatio~induced regulatory B cells in systemic lupus erythematosus显示文摘 | Nele G Dresel J Eckstein V | 2014 | Arthr Rheum2014，66，： | 1 |
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