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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | 瑞典卡罗林斯卡医学院公共卫生硕士的培养特色及启示显示文摘公共卫生硕士(master of public health,MPH)是国际公认的公共卫生领域主流学位,是为公共卫生领域培养的一种高层次人才。我国MPH教育尚处于起步阶段,随着高等教育的国际化趋势,人才培养模式必须适应国际化需求。本文从培养目标、课程专业设置、教学方法与管理、国际多元化培训等方面介绍了瑞典卡罗林斯卡医学院MPH的培养特色,提出我国未来MPH的发展要求,建立合理明确的培养目标,设置专业化硕士课程,采用灵活的教学方式,有效提升学生及授课教师的国际合作交流能力。 | 林玉兰 Nele Brusselaers | 2019 | 南京医科大学学报(社会科学版)2019，19，2： | 6 |
| 3 | Forty-six genes causing nonsyndromic hearing impairment: Which ones should be analyzed in DNA diagnostics?显示文摘 | Nele Hilgert Richard J.H. Smith Guy Van Camp | 2008 | Mutation Research-Reviews in Mutation Research2008，，2： | 3 |
| 4 | 微生物与矿物建筑材料的相互作用(英文)显示文摘综合介绍了比利时根特大学Magnel实验室与其他合作单位关于微生物与建筑材料(混凝土和石材)之间相互作用的研究概况。第一个研究课题是生物硫酸腐蚀,主要研究混凝土下水道系统和储肥设施的侵蚀。整个过程可用纯化学或微生物侵蚀实验来模拟。利用化学硫酸实验来模拟侵蚀过程的缺点是忽视了混凝土本身的杀菌效果。微生物实验结果表明使用具有高度中和能力的材料可限制生物腐蚀的发生。因此,生物硫酸侵蚀模型中不但需要考虑耐久性(如孔隙率),也需要把混凝土碱性列为参数之一。第二个研究课题是细菌在胶结固化和混凝土自修复中的应用。细菌诱导产生的碳酸钙用于水泥基材料和石灰石的表面防护。研究表明:沉积在表面的生物碳酸钙可有效降低混凝土吸水率、碳化和氯离子侵蚀;还能提高混凝土抗冻融性能。多孔石灰石表面固化深度可达到30mm甚至更多,固结区的强度可增加300%。与此同时,微生物碳酸钙也被应用于混凝土裂缝自修复。细菌先被固载于硅藻土或微胶囊内,然后加入到混凝土中与其一起搅拌。结果显示:加有硅藻土固载的细菌的砂浆试块上0.15~O.17mitt宽的裂缝可在40d内被细菌诱导产生的碳酸钙完全修复;而加有微胶囊固载的细菌的试块上1rnm宽的裂缝可以在3周内自修复完毕。微生物在混凝土中的另一个应用是创造绿色生态混凝土墙壁。这种混凝土墙壁经过特殊设计获得特定的微观结构和生物兼容性,从而可充当生物生长的基体。为了适于生物生长,使用低pH值的磷酸镁水泥混凝土和碳化水泥混凝土,并对其他影响生物兼容性的因素如混凝土孔隙率、表面粗糙度等进行了优化研究。 | Nele DE BELIE WANG Jianyun Willem DE MUYNCK Sandra MANSO BLANCO Ignacio SEGURO PEREZ | 2014 | 硅酸盐学报2014，42，5： | 3 |
| 5 | Integration of machine learning with phase field method to model the electromigration induced Cu_(6)Sn_(5) IMC growth at anode side Cu/Sn interface显示文摘Currently,in the era of big data and 5G communication technology,electromigration has become a serious reliability issue for the miniaturized solder joints used in microelectronic devices.Since the effective charge number(Z*)is considered as the driving force for electromigration,the lack of accurate experimental values for Z* poses severe challenges for the simulation-aided design of electronic materials.In this work,a data-driven framework is developed to predict the Z* values of Cu and Sn species at the anode based LIQUID,Cu_(6)Sn_(5) intermetallic compound(IMC)and FCC phases for the binary Cu-Sn system undergoing electromigration at 523.15 K.The growth rate constants(kem)of the anode IMC at several magnitudes of applied low current density(j=1×10^6 to 10×10^6A/m^2)are extracted from simulations based on a 1D multi-phase field model.A neural network employing Z* and j as input features,whereas utilizing these computed kemdata as the expected output is trained.The results of the neural network analysis are optimized with experimental growth rate constants to estimate the effective charge numbers.For a negligible increase in temperature at low j values,effective charge numbers of all phases are found to increase with current density and the increase is much more pronounced for the IMC phase.The predicted values of effective charge numbers Z* are then utilized in a 2D simulation to observe the anode IMC grain growth and electrical resistance changes in the multi-phase system.As the work consists of the aspects of experiments,theory,computation,and machine learning,it can be called the four paradigms approach for the study of electromigration in Pb-free solder.Such a combination of multiple paradigms of materials design can be problem-solving for any future research scenario that is marked by uncertainties regarding the determination of material properties. | Anil Kunwar Yuri Amorim Coutinho Johan Hektor Haitao Ma Nele Moelans | 2020 | Journal of Materials Science & Technology2020，59，24： | 3 |
| 6 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 7 | Bacterial carbonate precipitation as an alternative surface treatment for concrete显示文摘 | Willem D M Kathelijn C Nele D B | 2008 | Construction and Building Materials2008，22，5： | 1 |
| 8 | Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis显示文摘 | Sonia O Labeau Katrien Van de Vyver Nele Brusselaers Dirk Vogelaers Stijn I Blot | 2011 | The Lancet Infectious Diseases2011，，11： | 1 |
| 9 | Enhancing the Trust-based Recommendation Process with Explicit Dis-trust显示文摘 | Patricia V Nele V Chris C | 2013 | ACM Transactions on the Web2013，7，2： | 1 |
| 10 | Acoustic emission analysis for the quantification of autonomous crack healing in concrete显示文摘 | Van Tittelboom Kim De Belie Nele Lehmann Frank | 2012 | Construction and Building Materials2012，28，： | 1 |
| 11 | A torque and thrust prediction model for drilling of composite materials显示文摘 | Langella A Nele L Maio A | 2005 | Composites Part A:Applied Science and Manufacturing2005，36，1： | 1 |
| 12 | Influence of mix composition on the extent of autogenous crack healing by continued hydration or calcium carbonate formation显示文摘 | Kim Van Tittelboom Elke Gruyaert Hubert Rahier Nele De Belie | 2012 | Construction and Building Materials2012，，： | 1 |
| 13 | Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings 显示文摘 | NELE W SASCHA T JOKE D | 2010 | Environmental Pollution2010，158，9： | 1 |
| 14 | Asorbate and dehydroaseorbate influence cell cycle progression in a tobacco cell suspension显示文摘 | Potters G Nele H Roland J C | 2000 | Plant Physiol2000，11，24： | 1 |
| 15 | Use of bacteria to repair cracks in concrete显示文摘 | Kim Van Tittelboom Nele De Belie Willem De Muynck Willy Verstraete | 2009 | Cement and Concrete Research2009，，1： | 1 |
| 16 | Formation of 4-viayl and 4-ethyl derivatives from hydroxycinnamic acids: Occurrence of volatile phenolic flavour compounds in beer and distribution of Padl-aetivity among brewing yeasts显示文摘 | Nele Vanbeneden | 2007 | Food Chemistry2007，，8： | 1 |
| 17 | Bio-deposition of a calcium carbonate layer on degraded limestone by Bacillus species显示文摘 | Jan Dick Wim Windt Bernard Graef Hans Saveyn Paul Meeren Nele Belie Willy Verstraete | 2006 | Biodegradation2006，，4： | 1 |
| 18 | Improved ruthenium catalysts for the modifed friedlaender quinoline synthesis显示文摘 | Hans V M Nele L Bart A | 2007 | New J Chem2007，31，： | 1 |
| 19 | Pseudofossils in relictmethane seep carbonates resemble endemic microbial consortia 显示文摘 | BaileyJ Raub T D Nele Meckler A | 2010 | Palaeogeography Palaeoclimatology Palaeoecology2010，285，： | 1 |
| 20 | Safety and toxicity of intrathecal liposomal cytarabine ( Depocyte ) in children and adolescents with recurrent or refractory brain tumors:a multi-institutional retrospective study显示文摘 | Martin B Nele S Katja yon H | 2009 | Anti-Cancer Drugs2009，11，9： | 1 |
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