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| 1 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity显示文摘 | Beth Kelly Luke AJ O'Neill | 2015 | Cell Research2015，25，7： | 70 |
| 2 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 3 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 4 | 知情同意:从纽伦堡到赫尔辛基显示文摘知情同意被视为临床伦理学与研究伦理学的基本原则。大量的文献倡导提高同意的必要条件。据说,同意应当更加明确、具体。经验主义的证据显示,满足任何一方标准是极其困难的,有时是不可能的,因此,这些目标很难行得通。倡导知情同意不实际与不可能的要求,有极小的价值。讨论告知不能作为临床伦理学与研究伦理学的基本标准,知情同意可以最好视为病人与受试者以及其他人所能选择性放弃其他的义务,而不采取侵害性行为的一种方法。它提供了一种调节根本的义务的重要方式,这一义务是由尊重真正执行同意所需要的伦理标准与认识力的双方提供。 | Onora O' Neill 张斌(译) 赵明杰(审校) | 2006 | 医学与哲学(A)2006，27，11： | 21 |
| 5 | Performance characterization of Ni60-WC coating on steel processed with supersonic laser deposition显示文摘Ni60-WC particles are used to improve the wear resistance of hard-facing steel due to their high hardness. An emerging technology that combines laser with cold spraying to deposit the hard-facing coatings is known as supersonic laser deposition. In this study, Ni60-WC is deposited on low-carbon steel using SLD. The microstructure and performance of the coatings are investigated through SEM, optical microscopy, EDS, XRD, microhardness and pin-on-disc wear tests. The experimental results of the coating processed with the optimal parameters are compared to those of the coating deposited using laser cladding. | Fang LUO Andrew COCKBURN Martin SPARKES Rocco LUPOI Zhi-jun CHEN William O'NEILL Jian-hua YAO Rong LIU | 2015 | Defence Technology(防务技术)2015，11，1： | 11 |
| 6 | Hardfacing steel with nanostructured coatings of Stellite-6 by supersonic laser deposition显示文摘The ability to manufacture coatings is critical to engineering design. Many components require the application of additional layers toenhance mechanical properties and protect against hostile environments. Supersonic laser deposition (SLD) is a novel coating methodbased on cold spray (CS) principles. In this technique, the deposition velocities can be significantly lower than those required foreffective bonding in CS applications. The addition of laser heat energy permits a change in the thermodynamic experience of impactingparticles, thereby offering a greater opportunity for efficient bonding at lower velocities as compared with the CS process. The workreported in this paper demonstrates the ability of the SLD process to deliver hardfacing materials to engineering surfaces. Stellite-6 hasbeen deposited on low-carbon steel tubes over a range of process parameters to establish the appropriate target power and traversespeeds for the coating formation. The coating properties and parameters were examined to determine the primary characteristics andgrain structure size. Their morphology and performance were studied through optical microscopy, scanning electron microscope(SEM), X-ray diffraction, hardness measurements and wear testing. The results have shown that SLD is capable of depositing layers ofStellite-6, with properties that are superior to those of their conventionally manufactured counterparts. | Rocco Lupoi Andrew Cockburn Chris Bryan Martin Sparkes Fang Luo William O’Neill | 2012 | Light(Science & Applications)2012，1，1： | 8 |
| 7 | Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort显示文摘BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a significant percentage change between a normal and abnormal EUS(P=0.213).Median baseline MIC-1/GDF15 was greater in those with neoplastic tumours(Median=1039.6,interquartile range=727.0-1977.7)compared to those diagnosed with a benign lesion(Median=570.1,interquartile range=460.7-865.2)on EUS and MRI(P=0.012).CONCLUSION In this pilot study MIC-1/GDF15 has predictive capacity for neoplastic tumours in asymptomatic individuals with a genetic predisposition for PC.Further imagining may be warranted in patients with abnormal EUS and raised serum MIC-1/GDF15.Larger multicentric prospective studies are required to further define the role of MIC-1/GDF15 as a serological biomarker in pre-malignant pancreatic lesions and neoplastic tumours. | Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 8 | Do probiotics have a therapeutic role in gastroenterology?显示文摘Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in ’probiotics’, live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scienti?c basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease. | Jimmy K Limdi Catherine O’Neill John McLaughlin | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 9 | 粉红色和白色紫芽茶树花SPME/GC-MS香气成分分析显示文摘通过对5种不同开花程度的粉红色和白色紫芽茶树花进行SPME/GC-MS挥发性成分分析,发现红色和白色紫芽茶树花的芳香物质成分大体相同,但含量差异明显。两种茶树花挥发性成分可分为醇类、醛类、酯类、酮类、杂氧类、烷烃类、烯烃类、含氮类(呋喃/吲哚/吡喃)、萘/苯类。粉红色紫芽茶树花主要香气成分是苯乙酮、苯乙醇、芳樟醇、香叶醇、苯甲醇、α-甲基-苯甲醇、水杨酸甲酯、α-金合欢烯、大根香叶烯、摩勒烯、依兰烯、二十烷、2,6,10,14-四甲基十六烷、8-Isopropyl-1-methyl-3-methylenetricyclo[4.4.0.02,7]decanerel;白色紫芽茶树花主要香气成分是苯乙酮、芳樟醇、香叶醇、水杨酸甲酯、2,2,6-三甲基-6-乙烯基四氢-2H-吡喃-3-醇、吉玛烯。两种不同颜色的茶树花挥发性成分含量差异最大的是苯乙酮、水杨酸甲酯、芳樟醇、8-Isopropyl-1-methyl-3-methylenetricyclo[4.4.0.02,7]decanerel。聚类分析结果表明,粉红色和白色茶树花香气成分受茶树品种影响较大,以及粉红色茶树花不同开花阶段香气成分相对于白色茶树花的差异大。 | 陈美伴 Dylan O'Neill Rothenberg 张凌云 | 2018 | 广东农业科学2018，45，12： | 6 |
| 10 | Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease显示文摘Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson's disease(PD), whereas pharmacological approaches to increase noradrenaline bioavailability may provide neuroprotection. Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production(e.g., tumor necrosis factor-α, interleukin-1β & inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus. Neighbouring astrocyte populations promote a neurotrophic environment in response to β_2-adrenoceptor(β_2-AR) stimulation via the production of growth factors(e.g., brain derived neurotrophic factor, cerebral dopamine neurotrophic factor & glial cell derived neurotrophic factor which have shown promising neuroprotective and neuro-restorative effects in the nigrostriatal dopaminergic system. More recent findings have demonstrated a role for the β_2-AR in down-regulating expression levels of the human α-synuclein gene SNCA and relative α-synuclein protein abundance. Given that α-synuclein is a major protein constituent of Lewy body pathology, a hallmark neuropathological feature in Parkinson's disease, these findings could open up new avenues for pharmacological intervention strategies aimed at alleviating the burden of α-synucleinopathies in the Parkinsonian brain. In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via(1) inhibiting nigral microglial activation & pro-inflammatory mediator production,(2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and(3) downregulating α-synuclein gene expression and protein abundance in a β_2-AR-dependent manner. Thus, taken together, either pharmacologically enhancing extra-synaptic noradrenaline bioavailability or targeting glial β_2-ARs directly makes itself as a promising treatment option aimed at slowing/halting PD progression. | Eoin O'Neill Andrew Harkin | 2018 | Neural Regeneration Research2018，13，8： | 5 |
| 11 | Characteristics of Stellite 6 Deposited by Supersonic Laser Deposition Under Optimized Parameters显示文摘Stellite 6 powders were deposited on low carbon steel using SLD (supersonic laser deposition) under optimized parameters. The structure, line scan of elements and porosity of coating were examined and analyzed using SEM (scanning electron microscope), OM (optical microscope) and XRD (X-ray diffraction). The adhesion strength between coating and substrate was tested by PAT-ADHESION/TENSILE and E900STM adhesive. The results showed the deposition characteristics of optimized coating with N2 at a pressure of 3.0 MPa, a temperature of 450 ℃ and a laser power of 1.5 kW were compared with those of Stellite 6 coating deposited by the HVOF (high velocity oxygen fuel). | LUO Fang Lupoi Rocco Cockburn Andrew Sparkes Martin O'neill William YAO Jian-hua | 2013 | Journal of Iron and Steel Research(International)2013，20，2： | 4 |
| 12 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d’Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O’Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 4 |
| 13 | 2019年全球二氧化碳排放量趋于稳定,预计2020年将下降显示文摘根据国际能源署(IEA)于2020年2月发布的一份报告[1],全球与能源相关的二氧化碳(CO2)排放量在2019年趋于稳定,为33Gt。这一稳定是在全球经济增长速度为2.9%的背景下发生的[2]。二氧化碳排放的明显停滞掩盖了由于地理、技术和商业波动而导致的排放量增加和减少的多样性。 | Sean O’Neill | 2020 | Engineering2020，6，9： | 4 |
| 14 | 室外空气污染、早产和低出生体重:世界卫生组织孕产妇和围产期保健全球调查分析显示文摘[背景]吸入细颗粒物(颗粒物直径≤2.5μm,PM2.5)能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外PM2.5是否与不良妊娠结局相关。[方法]以有新生儿出生的各医疗诊所周围50 km为半径的圆弧缓冲区计算室外PM2.5的长期均值(2001—2006年)。应用广义估计方程确定诊所的PM2.5水平与个体的早产和低出生体重之间的相关性,调整个人、诊所和国家水平的季节性因素及潜在的混杂因素。另外还对各国中的相关性进行了研究。[结果]在所有国家中,调整季节性因素后,PM2.5与早产无关联,但是与低出生体重相关[PM2.5的第四个四分位数段(〉20.2μg/m3)与第一个四分位数(〈6.3μg/m3)相比,比值比(OR)=1.22;95%CI:1.07-1.39]。中国是PM2.5测量值范围最大的国家,早产和低出生体重均仅与PM2.5的最高四分位数段相关,提示可能存在阈值效应(PM2.5≥36.5μg/m3与PM2.5〈12.5μg/m3相比,早产和低出生体重比值比分别为:OR=2.54;CI:1.42-4.55和OR=1.99;CI:1.06-3.72)。[结论]室外PM2.5浓度与低出生体重相关,但与早产不相关。在快速发展的国家中,例如中国,最高的空气污染水平可能与两个结局都相关。 | Nancy L.Fleischer Mario Merialdi Aaron van Donkelaar Felipe Vadillo-Ortega Randall V.Martin Ana Pilar Betran Jo?o Paulo Souza Marie S.O'Neill 王晓宇 汪源 金泰廙 | 2014 | 环境与职业医学2014，31，12： | 4 |
| 15 | 在“同一个健康”框架下,加强兽医与人医合作,有效监测和应对人畜共患病和新发传染病显示文摘新发传染病主要是人畜共患病,是世界经济和公共健康的沉重负担。这就要求加强检测、鉴别和监视传染病的能力方面投入。高致病禽流感H5N1、新甲型流感('猪流感')H1N1、非典型性肺炎、西尼罗河病毒、地方流行性狂犬病、布鲁氏菌病以及发展中国家暴发的其它人畜共患病及近期猪抗甲氧西林金黄色葡萄球菌,是人类、动物及其环境相互作用的典型范例。面临中国动物和人类常见的新发传染病坚持'同一个健康'战略,这就要求业已存在的兽医和人医及公共卫生机构的通力合作。人的疾病控制系统与动物疾病控制系统虽然都已经建立,但人畜共患病的暴发表明兽医机构和人医机构密切合作的重要性。在保证环境健康的同时,通过动物疾病和人类疾病监测系统的密切合作,中国就一定能够控制人畜共患病。以这种方式进行疾病预防、监测与应对,各层面及各动物生产部门间有效的兽医推广是加强和保持健康生态环境中人和动物健康的有效办法。中国还需大量努力才能达到从制度上保证预防和消灭疾病。透明而准确的人与动物疾病监督通常会产生经济且可持续的预防疾病方法。加拿大在兽医、公共健康、食品安全和人畜共患病预防方面所发挥的作用就是与中国农业部合作,促进必要的、可持续的兽医监督网络的建设。 | Javier Burchard Tyler O’Neill 孙佩元 李宝根 | 2010 | 中国动物检疫2010，27，3： | 4 |
| 16 | Lid tectonics-Preface显示文摘The idea that plate tectonics may not have operated deep in Earth’s Precambrian past has a long legacy. What predated plate tectonics is unknown, and advances in data - from geochemical,geological and tectonic, to paleomagnetic, as well as modelling approaches,and planetary science, have the potential to contribute significantly to the debate. To contrast with the activity of plate tectonics,in this issue we use the term ‘lid tectonics’ to encapsulate a variety of envisaged regimes e from stagnant, sluggish, plutonicsquishy,or heat pipe - which are characterized by comparatively subdued tectonic signatures.This special issue of Geoscience Frontiers aims to present a snapshot of current research in the field of lid-tectonics - from detailed field interpretations, to global conceptual models, data compilations,and insights from simulations, and provide unique insights into both the Precambrian Earth, and the dynamics of lid-tectonics. | Craig O’Neill NickM.W.Roberts | 2018 | Geoscience Frontiers2018，9，1： | 3 |
| 17 | Geoclimatic factors influence the population genetic connectivity of Incarvillea arguta(Bignoniaceae)in the Himalaya-Hengduan Mountains biodiversity hotspot显示文摘Geoclimatic factors related to the uplift of the Himalaya and the Quaternary climatic oscillations in fluence the population genetic connectivity in the Himalaya-Hengduan Mountains(HHM)biodiversity hotspot.Therefore,to explore the relative roles played by these two factors,we examined the population dynamics and dispersal corridors of Incarvillea arguta(Royle)Royle incorporating ensemble species distribution modelling(SDM).Thirty-seven populations were genotyped using plastid chloroplast DNA and low copy nuclear gene(ncpCS)sequences.Phylogeographic analysis was carried out to reveal the genetic structure and lineage differentiation.Ensemble SDMs were carried out for distributional change in the last glacial maximum,present,and future.Finally,the least cost path method was used to trace out possible dispersal corridors.The haplotypes were divided into four clades with strong geographical structure.The late Miocene origin of I.arguta in the western Himalaya ca.7.92 Ma indicates lineage diversification related to the uplift of the HHM.The variability in habitat connectivity revealed by SDM is due to change in suitability since the Pleistocene.A putative dispersal corridor was detected along the drainage systems and river valleys,with strong support in the eastern Hengduan Mountains group.Our results support the signature of geoclimatic influence on population genetic connectivity of I.arguta in the HHM.We proposed that the major drainage systems might have assisted the rapid dispersal of isolated riverine plant species I.arguta in the HHM.The population genetic connectivity,using the fine-tuned ensemble SDMs,enables scientists and policymakers to develop conservation strategies for the species gene pool in the HHM biodiversity hotspots. | Santosh Kumar Rana Dong Luo Hum Kala Rana Alexander Robert O'Neill Hang Sun | 2021 | Journal of Systematics and Evolution2021，59，1： | 3 |
| 18 | Diagnostic Accuracy of Noninvasive Coronary Angiography Using 64-Slice Spiral Computed Tomography显示文摘 | Gilbert L. Raff Michael J. Gallagher William W. O’Neill James A. Goldstein | 2005 | Journal of the American College of Cardiology2005，，3： | 3 |
| 19 | The role of basic sciences in a problem‐based learning clinical curriculum显示文摘 | O’Neill | 2001 | Medical Education2001，，8： | 3 |
| 20 | Leaf temperature of soybean grown under elevated CO2 increases Aphis glycines (Hemiptera" Aphididae) population growth显示文摘在提高的二氧化碳(CO2 ) 下面种的植物经历为昆虫作为食物影响他们的适用性的生理的变化。为了决定靠大豆( Glycine 最大 Linnaeus )生活的效果,在提高的 CO2 下面成长,大豆蚜虫(蚜虫属 glycines Matsumura )的人口生长在伊利诺大学在 SoyFACE 研究地点被决定,Urbana平原,美国伊利诺,在下面成年提高( 550 L/L )并且周围( 370 L/L ) CO2 的层次。在提高的 CO2 下面的蚜虫人口的生长在 1 个星期以后是显著地更大的,与达到在 CO2 的周围的层次下面种的植物上的那些的尺寸两次的人口。在 CO2 的提高的层次下面种的大豆叶子以前在 SoyFACE 被表明增加了减少的有气孔的传导力引起的叶温度。把增加的叶温度与提高的 CO2 的另外的效果分开,当 CO2 水平被增加时,空气温度被降低,它降低了全面的叶温度到为在 CO2 的周围的层次下面种的叶子测量的那些。在提高的 CO2 下面种并且减少空气温度的植物上的蚜虫人口生长不比在在 CO2 的周围的层次下面种的植物上显著地大。由增加 Glycine 最大叶温度,提高了 CO2 可以在庄稼生产率上增加蚜虫属 glycines 和他们的影响的人口。 | Bridget F. O'Neill Arthur R. Zangerl Evan H. DeLucia Clare Casteel Jorge A. Zavala May R. Berenbaum | 2011 | Insect Science2011，18，4： | 3 |
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