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| 1 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity显示文摘 | Beth Kelly Luke AJ O'Neill | 2015 | Cell Research2015，25，7： | 70 |
| 2 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 3 | 全球生态系统服务与自然资本的价值估算显示文摘编者按:地球上的生态系统是一种复杂的生命支持系统,生态系统对人类的贡献,在生态学研究中经常用“社会效益和经济效益”来表述,是可以用经济价值来估算的。然而,由于其复杂性和不确定性,对这两个效益如何进行估价,一直是困扰生态学家和经济学家的重要问题。Cos... | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) | 1999 | 生态学杂志1999，18，2： | 38 |
| 4 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 5 | Nitric Oxide Mediates Gravitropic Bending in Soybean Roots显示文摘 | Xiangyang Hu Steven J. Neill Zhangcheng Tang Weiming Cai | 2005 | 中国生物学文摘2005，19，7： | 23 |
| 6 | 知情同意:从纽伦堡到赫尔辛基显示文摘知情同意被视为临床伦理学与研究伦理学的基本原则。大量的文献倡导提高同意的必要条件。据说,同意应当更加明确、具体。经验主义的证据显示,满足任何一方标准是极其困难的,有时是不可能的,因此,这些目标很难行得通。倡导知情同意不实际与不可能的要求,有极小的价值。讨论告知不能作为临床伦理学与研究伦理学的基本标准,知情同意可以最好视为病人与受试者以及其他人所能选择性放弃其他的义务,而不采取侵害性行为的一种方法。它提供了一种调节根本的义务的重要方式,这一义务是由尊重真正执行同意所需要的伦理标准与认识力的双方提供。 | Onora O' Neill 张斌(译) 赵明杰(审校) | 2006 | 医学与哲学(A)2006，27，11： | 21 |
| 7 | 学龄前儿童体力活动研究的10大问题显示文摘本文目的是回顾与3~5岁儿童体力活动有关的重要研究问题。本文将从三个主要研究领域进行分析:健康效果、体力活动模式、干预和政策。研究的主要问题包括:确定体力活动的健康效果,确定体力活动对保持健康体重的影响,探明体力活动对学习和行为习惯的影响,以及静坐行为对健康的影响。与体力活动模式相关的研究问题包括3~5岁儿童满足现有体力活动推荐量的情况;影响体力活动的社会和环境因素,包括家庭、幼儿园、社区环境;体力活动如何对学龄儿童期、青少年时期和成年以后产生影响。关于干预和政策方面的研究问题包括确定在家庭、保育机构、社区环境最有效的促进体力活动的干预策略,以及不同幼儿适用的干预方案;确定有效的干预手段和宣传策略;制定有效的能够增加幼儿体力活动水平的国家、州、地方和机构的政策。总之,全面了解体力活动对3~5岁儿童健康的影响,以便于掌握该群体的体力活动特点,探索如何促进幼儿的体力活动。 | Russell R.Pate Jennifer R.O'Neill William H.Brown Kerry L.McIver Erin K.Howie Marsha Dowda | 2015 | 北京体育大学学报2015，38，6： | 19 |
| 8 | BH3-only proteins target BCL-xL/MCL-1,not BAX/BAK,to initiate apoptosis显示文摘It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins(BID,BIM,etc.)directly engage and allosterically activate effector proteins BAX/BAK.Here,through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins,we demonstrate that all BH3-only proteins primarily target the anti-apoptotic BCL-2 proteins BCL-xL/MCL-1,whose simultaneous suppression enables membrane-mediated spontaneous activation of BAX/BAK.BH3-only proteins*apoptotic activities correlate with affinities for BCL-xL/MCL1 instead of abilities to directly activate BAX/BAK.Further,BID and BIM do not distinguish BAX from BAK or accelerate BAX/BAK activation following inactivation of BCL-xL/MCL-1.Remarkably,death ligandinduced apoptosis in cells lacking BH3-only proteins and MCL-1 is fully restored by BID mutants capable of neutralizing BCL-xL,but not direct activation of BAX/BAK.Taken together,our findings provide a'Membrane-mediated Permissive'model,in which the BH3-only proteins only indirectly activate BAX/BAK by neutralizing the anti-apoptotic BCL-2 proteins,and thus allowing BAX/BAK to undergo unimpeded,spontaneous activation in the mitochondrial outer membrane milieu,leading to apoptosis initiation. | Kai Huang Katelyn L.O'Neill Jian Li Wei Zhou Na Han Xiaming Pang Wei Wu Lucas Struble Gloria Borgstahl Zhaorui Liu Liqiana Zhang Xu Luo | 2019 | Cell Research2019，29，11： | 16 |
| 9 | 虚拟国际规范文档——连接德国国家图书馆和美国国会图书馆的规范文档显示文摘德国国家图书馆、美国国会图书馆和OCLC联机计算机图书馆中心联合开发了一个个人名称的虚拟国际规范文档(VIAF),它连接世界各国国家书目机构的规范记录,并免费提供网上检索,以证明自动连接不同国家规范文档的规范记录的可行性和优点。美国国会图书馆和德国国家图书馆的规范文档和书目文档被用来创建初始的VIAF,其中包括600多万个名称和50多万个连接。该项目的一个关键点是利用规范记录和其对应书目记录的信息开发自动名称匹配算法。该项目显示了用算法建立不同国家规范文档的个人名称之间连接的实用性。VIAF项目的长远目标是将许多国家图书馆和其他重要来源的规范名称结合起来,形成一个共享的全球规范服务。参考文献3。 | Rick Bennett Christina Hengel-Dittrich Edward T.O’Neill Barbara B.Tillett 顾犇 | 2006 | 国家图书馆学刊2006，15，4： | 15 |
| 10 | Targeting immunometabolism as an anti-inflammatory strategy显示文摘The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors,but are also a way of controlling immunity and inflammation.Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses.Four anti-inflammatory therapies,DMF,Metformin,Methotrexate and Rapamycin all work by affecting metabolism and/or regulating or mimicking endogenous metabolites with anti-inflammatory effects.Evidence is emerging for the targeting of specific metabolic events as a strategy to limit inflammation in different contexts.Here we discuss these recent developments and speculate on the prospect of targeting immunometabolism in the effort to develop novel anti-inflammatory therapeutics.As accumulating evidence for roles of an intricate and elaborate network of metabolic processes,including lipid,amino acid and nucleotide metabolism provides key focal points for developing new therapies,we here turn our attention to glycolysis and the TCA cycle to provide examples of how metabolic intermediates and enzymes can provide potential novel therapeutic targets. | Eva M.Palsson-McDermott Luke A.J.O'Neill | 2020 | Cell Research2020，30，4： | 12 |
| 11 | Mitogen-activated protein kinases mediate the oxidative burst and saponin synthesis induced by chitosan in cell cultures of Panax ginseng显示文摘Chitosan (CHN) specially induced the activities of 39 kD and 42 kD protein kinases in ginseng cells, which could be suppressed by an inhibitor of mitogen-activated protein kinase (MAPK) pathway, PD98059. The immunoprecipitation (IP) using MAPK antibody or kinase assay in vitro also showed that CHN-induced 42 kD and 39 kD protein kinases belonged to the MAPK family. PD98059 suppressed CHN-induced transcriptions of ginseng squalene synthase and ginseng squalene epoxidase genes (gss and gse), CHN-induced accumulation of b-Amyrin synthase (b-AS) and synthesis of saponin. These results showed that CHN-induced activities of MAPKs were necessary for the CHN-induced saponin synthesis. EGTA and LaCl3 suppressed CHN-induced 39 kD and 42 kD MAPK activities. Ruthenium red (RR) could suppress CHN-induced 39 kD activity. All of them suppressed CHN-induced saponin synthesis. These results indicated that CHN-induced increment of cytosolic calcium was necessary for CHN-induced saponin synthesis. PD98059 also suppressed CHN-induced oxidative burst (in-cluding the increment of activity of plasma membrane NADPH oxidase and production of H2O2), but diphenylene iodonium (DPI), dimethylthiourea (DMTU) and 2,5-dihydroxycinnamic acid methyl ester (DHC) could not suppress CHN-induced MAPK activities, which indicated that MAPK was possibly function upstream of CHN-induced oxidative burst. | Steven J. NEILL | 2004 | Science China(Life Sciences)2004，47，4： | 12 |
| 12 | 更好地报告随机试验中的危害:CONSORT声明扩展版显示文摘面对随机对照试验(RCTs)报告质量过低的种种确凿证据和严重后果,许多医学杂志及编辑小组现已接受并支持一份包含有22个条目的清单和一个流程图的CONSORT声明(试验报告统一标准)。由于CONSORT的主旨是提高干预措施疗效的报告质量,故其中只有一个条目是具体针对安全性的。大量证据表明,报告RCT中的危害的相关数据的报告质量有待提高。2003年5月,CONSORT小组成员,包括杂志编辑和科学家,齐聚加拿大魁北克省Mentoebello探讨了这一问题,并形成以下文件:标准CONSORT清单附带报告危害相关问题的10个新推荐意见,并附上说明及恰当报告的实例。我们希望该声明连同其它CONSORT相关材料(www.consort-statement.org)将有助于作者提高RCT报告中与危害相关数据的报告质量。高质量报告有助于读者批判性评价和诠释试验结果。各杂志可通过修改稿约来向作者传达这一文件以支持这一目标。 | John P.A.Ioannidis Stephen J.W.Evans Peter C.G■tzsche Robert T.O’Neill Douglas G.Altman Kenneth Schulz David Moher 杜亮 | 2006 | 中国循证医学杂志2006，6，9： | 12 |
| 13 | Performance characterization of Ni60-WC coating on steel processed with supersonic laser deposition显示文摘Ni60-WC particles are used to improve the wear resistance of hard-facing steel due to their high hardness. An emerging technology that combines laser with cold spraying to deposit the hard-facing coatings is known as supersonic laser deposition. In this study, Ni60-WC is deposited on low-carbon steel using SLD. The microstructure and performance of the coatings are investigated through SEM, optical microscopy, EDS, XRD, microhardness and pin-on-disc wear tests. The experimental results of the coating processed with the optimal parameters are compared to those of the coating deposited using laser cladding. | Fang LUO Andrew COCKBURN Martin SPARKES Rocco LUPOI Zhi-jun CHEN William O'NEILL Jian-hua YAO Rong LIU | 2015 | Defence Technology(防务技术)2015，11，1： | 11 |
| 14 | 反熔丝FPGA技术是卫星应用的理想选择显示文摘 | KenO'Neill | 2005 | 电子产品世界2005，12，10B： | 11 |
| 15 | Gibberellin-regulated XET is differentially induced by auxin in rice leaf sheath bases during gravitropic bending显示文摘 | Dayong Cui Steven J. Neill Zhangcheng Tang Weiming Cai | 2005 | 中国生物学文摘2005，19，7： | 9 |
| 16 | Hardfacing steel with nanostructured coatings of Stellite-6 by supersonic laser deposition显示文摘The ability to manufacture coatings is critical to engineering design. Many components require the application of additional layers toenhance mechanical properties and protect against hostile environments. Supersonic laser deposition (SLD) is a novel coating methodbased on cold spray (CS) principles. In this technique, the deposition velocities can be significantly lower than those required foreffective bonding in CS applications. The addition of laser heat energy permits a change in the thermodynamic experience of impactingparticles, thereby offering a greater opportunity for efficient bonding at lower velocities as compared with the CS process. The workreported in this paper demonstrates the ability of the SLD process to deliver hardfacing materials to engineering surfaces. Stellite-6 hasbeen deposited on low-carbon steel tubes over a range of process parameters to establish the appropriate target power and traversespeeds for the coating formation. The coating properties and parameters were examined to determine the primary characteristics andgrain structure size. Their morphology and performance were studied through optical microscopy, scanning electron microscope(SEM), X-ray diffraction, hardness measurements and wear testing. The results have shown that SLD is capable of depositing layers ofStellite-6, with properties that are superior to those of their conventionally manufactured counterparts. | Rocco Lupoi Andrew Cockburn Chris Bryan Martin Sparkes Fang Luo William O’Neill | 2012 | Light(Science & Applications)2012，1，1： | 8 |
| 17 | Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort显示文摘BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a significant percentage change between a normal and abnormal EUS(P=0.213).Median baseline MIC-1/GDF15 was greater in those with neoplastic tumours(Median=1039.6,interquartile range=727.0-1977.7)compared to those diagnosed with a benign lesion(Median=570.1,interquartile range=460.7-865.2)on EUS and MRI(P=0.012).CONCLUSION In this pilot study MIC-1/GDF15 has predictive capacity for neoplastic tumours in asymptomatic individuals with a genetic predisposition for PC.Further imagining may be warranted in patients with abnormal EUS and raised serum MIC-1/GDF15.Larger multicentric prospective studies are required to further define the role of MIC-1/GDF15 as a serological biomarker in pre-malignant pancreatic lesions and neoplastic tumours. | Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 18 | 胶北粉子山群石榴云母片岩的三叠纪独居石年龄及其地质意义显示文摘胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和CaO含量变化特征表明其核部到边部温度先升高后降低,对应进变质及退变质过程。根据原位独居石Y元素成分面扫描图显示,部分独居石颗粒由核部到边部Y含量呈现逐渐降低趋势,说明测得的232.6±1.1Ma^229.5±3.7Ma的独居石U-Pb年龄,对应石榴石的进变质生长过程。结合1869±72Ma的锆石U-Pb年龄数据,可推断粉子山群石榴云母片岩至少经历了古元古代及三叠纪两期变质事件的改造。粉子山群石榴云母片岩卷入了苏鲁超高压变质带的俯冲碰撞造山事件。电子探针成分分析结果表明粉子山群石榴云母片岩中的石榴石属于铁铝榴石,反映出经受中级区域变质作用的特征。说明粉子山群石榴云母片岩虽然参与了三叠纪苏鲁超高压变质带的俯冲碰撞造山过程,但俯冲深度较浅。这可用大陆俯冲过程中上盘的俯冲剥蚀来解释,并可为陆-陆碰撞俯冲剥蚀模式提出的扬子板片在240~220Ma的深俯冲作用过程中拽动胶北地块向下俯冲又折返的运动过程提供佐证,但胶北地块是否经历了深俯冲超高压变质作用,还需要进一步验证。 | 曹汇 VERVOORT Jeff 王达 李广旭 NEILL Owen | 2016 | 岩石学报2016，32，12： | 7 |
| 19 | 绿篱控制土壤侵蚀效果的研究显示文摘在肯尼亚中部高地的淋溶土上 ,对树绿篱、草绿篱和树草绿篱等 3种生物绿篱进行了试验研究。分别对作物生长季节中试验区的土壤侵蚀量、干物质生物量和地形变化特征进行了调查和测试。树绿篱、树草绿篱、草绿篱和对照 (无绿篱 )各试验区累计平均土壤侵蚀量分别为 5 6、7 4、11 2和 10 9t/hm2 ;树绿篱、树草绿篱和草绿篱干物质生物量分别达到 2 980、9 2 4和 11 9t/ (hm2 ·a) ;地形测量表明 ,各绿篱试验区的梯田地形都有一个均一的变化过程 ,坡度降低 0 2 % ,但对照区坡度增加 0 2 %。该项研究对于开展复合农林业 ,保护土壤 ,发展可持续农业具有重要的指导意义。 | S.D.Angima M.K.O'Neill A.K.Omwega D.Estott 项欣 李岩 李强 | 2001 | 水土保持应用技术2001，，3： | 7 |
| 20 | 绝经过渡期与绝经后激素治疗指导国际绝经协会执行委员会的立场声明显示文摘 | F.Naftolin H.P.G.Schneider D.W.Sturdee M.Birkhauser M.P.Brincat M.Gambacciani A.R.Genazzani(Ex officio) K.K.Li mpaphayom S.O’Neill S.Palacios A.Pines N.Siseles D.Tan H.G.Burger(Ex officio) 宫伟雁 | 2005 | 国外医学(妇幼保健分册)2005，16，5： | 7 |
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