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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Predictors of outcome following hip fracture. Admission time predicts length of stay and in-hospital mortality显示文摘 | John E Clague Elaine Craddock Glynn Andrew Michael A Horan Neil Pendleton | 2002 | Injury2002，，1： | 2 |
| 4 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 5 | Cytokine therapy:a natural alternative for disease control显示文摘 | Lowenthal J W O Neil T E | 1999 | Vet Immunol Immunopathol1999，，72： | 1 |
| 6 | Trinexapac-ethyl influence on cell membrane thermostability of Kentucky bluegrass leaf tissue显示文摘 | Neil L H Garald L H Roch E G | 2002 | Scinesia Horticulturae2002，92，： | 1 |
| 7 | Extension of human cell lifespan by nicotinamide phosphoribosyltransferase显示文摘 | van der Veer E Ho C O'Neil C | 2007 | J Biol Chem2007，282，10： | 1 |
| 8 | Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O′Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 9 | Salinity effects on the microwave emission of soil显示文摘 | Jackson T J O'Neil P E | 1990 | Remote Sens Environ1990，31，： | 1 |
| 10 | N-acyl homoserine lactone binding to the CarR receptor determines quorumsensing specificity in Erwinia 显示文摘 | Martin W Daniel E T Neil A | 2000 | EMBO J2000，1999，4： | 1 |
| 11 | Model simulations examining the relation of lake-effect morphology to lake shape, wind direction, and wind speed显示文摘 | Neil F E John | 2003 | Mon Wea Rev2003，131，： | 1 |
| 12 | Effeets of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans显示文摘 | Tara E Saekett G H Neil Towers Murray B Isman | 2007 | Chemoecology2007，17，： | 1 |
| 13 | Comparison of the effects of two methods of cryopresevation on testicular sperm DNA显示文摘 | E Kristine Steele Neil Mcclure Sheena E | 2000 | Fertil Steril2000，74，： | 1 |
| 14 | Recombinant chicken IFN-γ expressed in Escherichia coli: Analysis of C-terminal truneation and effeet on biologie aetivity显示文摘 | Miehalski W P Shiell B J O'Neil T E | 1999 | Journal of Interferon & Cytokine Researeh1999，19，4： | 1 |
| 15 | Quantitative ex-pression of osteopontin in nasal mucosa of patients with allergic rhi-nitis :effects of pollen exposure and nasal glucocorticoid treatment显示文摘 | O’NEIL S E MALMHALL C SAMITAS K | 2010 | Allergy Asthma and Clinical Immunology2010，6，1： | 1 |
| 16 | Pre-B-cell colony-enhancing factor regulates NAD +-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation 显示文摘 | van der Veer E Nong Z O'Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 17 | Pre-B-cell colonyenhancing factor regulates NAD +-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O' Neil C | 2005 | Circ Res2005，97，1： | 1 |
| 18 | Role of calpain in skeletal-muscle protein degradation显示文摘 | HUANG J NEIL E F | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，12： | 1 |
| 19 | Potential use of cytokine therapy in poultry显示文摘 | Lowenthal J W York J J O'Neil T E | 1998 | Vet Immunol Immunopathol1998，63，12： | 1 |
| 20 | An optimality proof of the LRU-K page replacement algorithm显示文摘 | O'NEIL E 1 O'NEIL P E WEIKUM G | 1999 | Journal of the ACM1999，46，1： | 1 |
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