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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 3 | Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis显示文摘 | Neel R Gandhi Paul Nunn Keertan Dheda H Simon Schaaf Matteo Zignol Dick van Soolingen Paul Jensen Jaime Bayona | 2010 | The Lancet2010，，9728： | 2 |
| 4 | Effcieney of boundary evaluation for a cellular model显示文摘 | Bidarra R Madeira J Neels W | 2005 | Computer- Aided Design2005，37，12： | 1 |
| 5 | Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems 显示文摘 | McLean K J Dunford A J Neel R | 2007 | Arch Biochem Biophys2007，464，2： | 1 |
| 6 | Two human c-onc genes are located on the long arm of chromosome 8 显示文摘 | Neel B G Jhanwar S C Chaganti R S Hayward W S | 1982 | Proc Natl Acad Scl USA1982，79，24： | 1 |
| 7 | Use of a smooth press - fit stem preserves physeal growth after tumor resection 显示文摘 | Neel MD Heck R Britton L | 2004 | Clin Orthop2004，，426： | 1 |
| 8 | Motion- induced inhibition of elongation and induction of dormancy in Liquidambar显示文摘 | Neel P L Harris R W | 1971 | Science1971，173，： | 1 |
| 9 | Chloroplast DNA diversity in populations of wild and cultivated barley显示文摘 | Neele D B Saghai M A Allard R W | 1988 | Genetics1988，120，： | 1 |
| 10 | Efficiency of boundary evaluation for a cellular model 显示文摘 | Bidarra R Bronsvoort W F Neels W J | 2005 | Computer-Aided Design2005，37，12： | 1 |
| 11 | Convergence of Cognitive Radio Networks显示文摘 | NEEL J O REED J H GILLES R P | 2004 | Wireless Communications and Networking Conference 20042004，4，3： | 1 |
| 12 | Efficiency of boundary evaluation for a cellular model 显示文摘 | Bidarra R Madeira J NEELS W J | 2005 | Computer Aided Design2005，37，12： | 1 |
| 13 | Use of a smooth press -fit stem preserves physeal growth after tumor resection显示文摘 | Neel MD Heck R Britton L | 2004 | Clin Orthop Relat Res2004，426，： | 1 |
| 14 | Quantized conductance of a single magnetic atom 显示文摘 | NEEL N KROGER J BERNDT R | 2009 | Phys Rev Lett2009，102，08： | 1 |
| 15 | Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation显示文摘 | Matin T.M Keith K Davies B Conner D.A Guha P Kalaitzidis D Wu X Lauriol J Wang B Bauer M Bronson R Franchini K.G Neel B.G Kontaridis M.I | | 0，，： | 1 |
| 16 | Computational and experimental investigation of supersonic convection over a laser heated target显示文摘 | Marineau E C Schetz J A Neel R E | 2009 | Journal of Thermophysics and Heat Transfer2009，23，3： | 1 |
| 17 | Near Shannon limit performance of low density parity cheek codes 显示文摘 | Mackay D J C Neel R M | 1996 | Electronic Letters1996，32，18： | 1 |
| 18 | Identification of a human src homology 2-containing protein-tyrosine-phosphatase:a putative homolog of Drosophila corkscrew显示文摘 | Freeman R M Plutzky J Neel B G | 1992 | Proc Natl Acad Sci U S A1992，89，11： | 1 |
| 19 | Analysis of fluoride in rain water compari- son of capillary electrophoresis with ion chromatography and ion-selective electrode potentiometry显示文摘 | Van den Hoop M A G T Cleven R F M J Van Staden J J Neele J | 1996 | Journal of Chromatography A1996，739，1： | 1 |
| 20 | Game theoretic analysis of a net- work of cognitive radios显示文摘 | Neel J Buehrer R M Reed B H | 2002 | The 45th Midwest Symposium on Cir- cuits and Systems2002，3，6： | 1 |
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