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| 1 | Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer显示文摘BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and oxaliplatin.Studies have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is limited.AIM To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic factors.METHODS One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively analysed.Oxaliplatin and MMC were used in 68 and 34 patients,respectively.Each patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were noted.Complications were stratified and graded using Clavien/Dindo analysis.Prognostic outcome factors were identified using univariate and multivariate analysis of survival.RESULTS The two groups did not differ significantly regarding baseline characteristics.We found no difference in median overall survival between MMC and oxaliplatin HIPEC.Regarding postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal carcinomatosis.Multivariate analysis of survival confirmed primary distant metastasis and primary tumour resection status to have a significant impact on survival and likewise peritoneal cancer index-scoring regarding peritoneal carcinomatosis.CONCLUSION In this single-institution retrospective review of patients undergoing CRS with either oxaliplatin or MMC HIPEC,overall survival was not different,though oxaliplatin was associated with a higher postoperative complication rate,indicating treatment favourably with MMC.Further studies comparing HIPEC regimens would improve evidence-based decision-making. | Julia Spiegelberg Hannes Neeff Philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 3 |
| 2 | Solitary fi- brous tumour of the liver- case report and review of the litera- ture显示文摘 | Neeff H Obermaier R Technau Ihling K | 2004 | LangenbecksArchSurg2004，389，： | 1 |
| 3 | Tropical forest measurement by interferometric height modeling and Pband radar backscatter显示文摘 | Neeff T Dutra L V dos Santos J R | | 0，，06： | 1 |
| 4 | Hochechte organische pigmente显示文摘 | Prof M Neeff Nene R | 1984 | Dees and Pigment1984，5，： | 1 |
| 5 | Perioperative mortali-ty after non-hepatic general surgery in patients with liver cirrhosis:ananalysis of 138 operations in the 2000s using child and MELD scores显示文摘 | Neeff H Mariaskin D Spangenberg HC | 2010 | J Gastrointest Surg2010，15，1： | 1 |
| 6 | Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s using Child and MELD scores 显示文摘 | Neeff H Mariaskin D Spangenberg HC | 2011 | J Gastrointest Surg2011，15，1： | 1 |
| 7 | Embryonic lymphangiogenesis显示文摘 | Wilting J Neeff H Christ B | 1999 | Cell Tissue Res1999，297，： | 1 |
| 8 | Hepatic resection for hepatocellular carcinoma-results and analysis of the current litera- ture显示文摘 | Neeff H Makowiec F Harder J | 2009 | Zentralbl Chir2009，134，2： | 1 |
| 9 | Intracranial/Extracranial Meningioma Arising in the Hypoglossal Canal: Case Report显示文摘 | Michel Neeff Elif Baysal Jarrod Homer James Gillespie Richard Ramsden | 2007 | Skull Base2007，，05： | 1 |
| 10 | Impact of preoperative targeted therapy on postoperative complications after resection of colorectal liver metastases 显示文摘 | Neeff HP Drognitz 0 Klock A | 2012 | Int J Colorectal Dis2012，27，5： | 1 |
| 11 | In vitro and in vivo efficacy of a hydrated sodium calci- um aluminosilicate to bind and reduce aflatoxin resi- dues in tissues of broiler chicks fed aflatoxin B1 显示文摘 | Neeff D V Ledoux D R Rottinghaus G E | 2013 | Poultry Science2013，92，1： | 1 |
| 12 | Embryonic lymphangiogene-sis显示文摘 | Wilting J Neeff H Christ B | 1999 | Cell Tissue Res1999，297，1： | 1 |
| 13 | Nonlinear antenna technology显示文摘 | Meadows K Heath Ted Neeff J D | 2002 | Proc IEEE2002，90，： | 1 |
| 14 | Apoptosis is caused by prolonged organ preservation and blocked by apoptosis inhibitor in experimental rat pancreatic grafts显示文摘 | Liu X Drognitz O Neeff H | 2004 | Transplant Proc2004，36，4： | 1 |
| 15 | Significance of total vascular exclusion for hepatic cryotherapy:an experimental study显示文摘 | Jungraithmayr W Szarzynski M Neeff H | 2004 | J Surg Res2004，116，： | 1 |
| 16 | Hepatic resection for hepatocellular carcinoma-results and analysis of the current literature显示文摘 | Neeff H Makowiec F Harder J | 2009 | Zentralblatt für Chirurgie2009，，： | 1 |
| 17 | Glutamine and glutamine synthetase in the neonatal rat brain following hypoxia 显示文摘 | Kraja C D NEeff N H Glutamate H M | 1996 | Brain Res1996，707，10： | 1 |
| 18 | Apoptosis is caused by prolonged organ preservation and blocked by apoptosis inhibitor in experimental rat pancreatic grafts显示文摘 | Liu X Drognitz O Neeff H et at | 2004 | Transplant Proc2004，36，4： | 1 |
| 19 | Outcome after repeat re- section of liver metastases from colorectal cancer显示文摘 | Neeff HP Drognitz O Holzner P | 2013 | Int J Color-ectal Dis2013，28，8： | 1 |
| 20 | Solitary fibrous tumour of the liver: case report and review of the literature显示文摘 | Hannes Neeff R. Obermaier K. Technau-Ihling M. Werner C. Kurtz A. Imdahl U. T. Hopt | 2004 | Langenbeck’s Archives of Surgery2004，，4： | 1 |
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