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| 1 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 2 | Development and application of traffic accident density estimation models using kernel density estimation显示文摘Traffic accident frequency has been decreasing in Japan in recent years.Nevertheless,many accidents still occur on residential roads.Area-wide traffic calming measures including Zone 30,which discourages traffic by setting a speed limit of 30 km/h in residential areas,have been implemented.However,no objective implementation method has been established.Development of a model for traffic accident density estimation explained by GIS data can enable the determination of dangerous areas objectively and easily,indicating where area-wide traffic calming can be implemented preferentially.This study examined the relations between traffic accidents and city characteristics,such as population,road factors,and spatial factors.A model was developed to estimate traffic accident density.Kernel density estimation(KDE) techniques were used to assess the relations efficiently.Besides,16 models were developed by combining accident locations,accident types,and data types.By using them,the applicability of traffic accident density estimation models was examined.Results obtained using Spearman rank correlation show high coefficients between the predicted number and the actual number.The model can indicate the relative accident risk in cities.Results of this study can be used for objective determination of areas where area-wide traffic calming can be implemented preferentially,even if sufficient traffic accident data are not available. | Seiji Hashimoto Syuji Yoshiki Ryoko Saeki Yasuhiro Mimura Ryosuke Ando Shutaro Nanba | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，3： | 3 |
| 3 | Nitrile hydratase of Pseudomonas chlororaphis B23: Purification and characterization 显示文摘 | Nagasawa T Nanba H Ryuno K Takeuchi K Yamada H | 1987 | Eur J Biochem1987，162，： | 1 |
| 4 | Antitumor activity of oral administered' D2Fraction' from maitake mushroom( Grifola frondosa) 显示文摘 | NANBA H | 1993 | Nat Med1993，1，4： | 1 |
| 5 | New anterolateral thigh perforator flap with a short pedicle for reconstruction of defects in the upper extremities显示文摘 | Koshima I Nanba Y Tsutsui T | 2003 | Ann Plast Surg2003，51，1： | 1 |
| 6 | Catalytic performance of Pt supported on various metal oxides in the oxidation of carbon black显示文摘 | OI-UCHISAWA J OBUCHI A ENOMOTO R LIU S T NANBA T KUSHIYAMA S | 2000 | Appl Catal B:Environmental2000，26，： | 1 |
| 7 | Cu doping effect on FePt grains prepared by rapid thermal annealing on SiO2 substrate and wall structure in TbFeCo/FePt CGC-like film显示文摘 | Itoh A Itoh Y Nanba K | 2006 | Appl Phys2006，99，： | 1 |
| 8 | Sequence analysis and bioinformatics analysis of chromosome 17q25 in familial moyamoya disease显示文摘 | Nanba R Tada M Kuroda S | 2005 | Childs Nerv Syst2005，21，1： | 1 |
| 9 | Perforator flaps in lower extremity reconstruction 显示文摘 | Koshima I Nanba Y Tsutsui T | 2002 | Handchir Mikrochir Plast Chir2002，34，4： | 1 |
| 10 | The chemical stmcture of an antitumor polysaccharide in fruit bodies of Grifola frondosa (Maitake) 显示文摘 | NANBA H HAMAGUCHI A KURODA H | 1987 | Chemical and Pharmaceutical Bulletin1987，35，3： | 1 |
| 11 | Nitrile hydratase of Pseudomonas chlororaphis B23 purification and characterization显示文摘 | Nagasawa T Nanba H Ryuno K | 1987 | Eur J Biochem1987，162，： | 1 |
| 12 | Clinical features and outcomes of 10 asymptomatic adult patients with moyamoya disease显示文摘 | Kuroda S Takeda M | 2003 | No Shinkei Geka2003，31，： | 1 |
| 13 | Prediction of microstructure distribution in the through-thickness direction during and after hot rolling in carbon steel显示文摘 | Nanba S Kitamura M Shimida M | 1992 | ISIJ International1992，32，3： | 1 |
| 14 | Potentiation of hostmeditcd antitumor activity in mice by betaglucan obtained from Grifola frondosa (maitake) 显示文摘 | Adachi K Nanba H Kuroda H | 1987 | Chem Pharm Bull (Tokyo)1987，35，： | 1 |
| 15 | Characterization of amorphous tungsten trioxide thin films prepared by RF magnetron sputtering method 显示文摘 | Tokuro Nanba | 1994 | Joural of Non-Crystalline Sloids1994，178，： | 1 |
| 16 | Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production显示文摘 | Kodama N Mizuno S Nanba H | 2010 | Journal of medicinal hod2010，13，1： | 1 |
| 17 | Hepatitis B Virus Gene in Liver Tissue Promotes Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients显示文摘 | Shin-Ichi Fujioka Hiroyuki Shimomura Yoshiaki Iwasaki Kozo Fujio Hiroshi Nakagawa Yasuhiro Onishi Shinjiro Takagi Hideaki Taniguchi Fumi Umeoka Hirofumi Nakajima Akio Moriya Katsuyuki Nanba Cheng-Yu Piao Toshiyuki Shinji Norio Koide Yasush Shiratori | 2003 | Digestive Diseases and Sciences2003，，10： | 1 |
| 18 | Non-radioactive DNA diagnosis for the fragile X syndrome in mentally retarded Japanese males显示文摘 | Nanba E Kohno Y Matsuda A | 1995 | Brain Dev1995，17，： | 1 |
| 19 | Abnormal expansion of peripheral γδ T cells in patients with neurologic disorders显示文摘 | Yamamoto T Hara T Nanba E | 1997 | Brain Behav Immun1997，11，3： | 1 |
| 20 | Nontraumatic paralysis of the posterior interosseous nerve显示文摘 | Nishida K Nanba Y | 1996 | J Bone Joint Surg Br1996，78，5： | 1 |
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