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| 1 | Follow up of infection of chacma baboons with inoculum containing a and non-a genotypes of hepatitis B virus显示文摘AIM: To determine whether one genotype (A or non-A genotypes of HBV) predominated over the other during the course of HBV infection.METHODS: Four baboons were inoculated with HBV. DNA was extracted from serum obtained at monthly intervals postinoculation for 52 weeks and HBV DNA was amplified using primers specific for the core region containing an insert characteristic of genotype A (nt 2 354-2 359, numbering from the EcoRI site). The amplicons were cloned into PCRScriptTM and a minimum of 15 clones per time point were sequenced in both directions.RESULTS: Both genotypes persisted for the entire followup period of 52 weeks. Genotype non-A predominated in two baboons and genotype A in one baboon. Neither genotype predominated in the fourth baboon, as shown at a 5 % level of testing.CONCLUSION: No conclusions concerning the dominance of either genotype or the natural progression or replication rates of HBV could be drawn because the pattern of the genotypes found may have been caused by sampling fluctuations at the time of DNA extraction and cloning as a result of the very low viral loads in the baboon sera. | Marina Baptista Anna Kramvis Saffie Jammeh Jocelyn Naicker Jacqueline S. Galpin Michael C. Kew | 2003 | World Journal of Gastroenterology2003，9，4： | 4 |
| 2 | African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era. | Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 3 | Chronic kidney disease: global dimension and perspectives显示文摘 | Vivekanand Jha Guillermo Garcia-Garcia Kunitoshi Iseki Zuo Li Saraladevi Naicker Brett Plattner Rajiv Saran Angela Yee-Moon Wang Chih-Wei Yang | 2013 | The Lancet2013，，9888： | 2 |
| 4 | Acid mine drainage arising from gold mining activity in Johannesburg,South Africa and environs显示文摘 | Naicker K Cukrowska E McCarthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 5 | Acute kidney injury associated with the use of traditional medcines 显示文摘 | Luyckx VA Naicker S | 2008 | Nat Cfin Pract Nephrol2008，4，12： | 1 |
| 6 | nutrional problems associated with end-stage renal disease in the developing world显示文摘 | Naicker S | 2002 | Artif Organs2002，26，： | 1 |
| 7 | Nutritional problems associated with end-stage renal disease in the developing world 显示文摘 | Naicker S | 2002 | Artif Organs2002，26，9： | 1 |
| 8 | Comparison of pregnancy outcomes in women with hypertensive disorders of pregnancy using 24-hour urinary protein and urinary microalbumin to creatinine ratio显示文摘 | Gangaram R Naicker M Moodley J | | 0，，01： | 1 |
| 9 | Hexane cardiotoxicity-an experimental study显示文摘 | Khedun SM Maharaj B Naicker T | 1996 | Isr J Med Sci1996，32，2： | 1 |
| 10 | Birth weight, stress, and symptoms of depression in adoles- cence : evidence of fetal programming in a national Ca- nadian cohort 显示文摘 | Colman I Ataullahjan A Naicker K | 2012 | Can J Psychiatry2012，57，7： | 1 |
| 11 | Nutritional problems associated with end-stage renal disease in the developing world显示文摘 | Naicker S | 2002 | Artif Organs2002，26，9： | 1 |
| 12 | Accuracy of the spot urinary microalbumin:creatinine ratio and visual dipsticks in hypertensive pregnant women显示文摘 | Gangaram R Naicker M Moodley J | | 0，，02： | 1 |
| 13 | The use of computer games as an educational tool :identification of appropriate game types and game elements 显示文摘 | Amory A Naicker K Vincent J & Adams C | 1999 | British Journal of Education Technology1999，30，4： | 1 |
| 14 | Acid mine drainage arising from gold mining activity in Johannesburg, South Africa and envi- rons 显示文摘 | Naicker K Cukrowska E McCarthy T S | 2003 | Environmental Pollution2003，22，1： | 1 |
| 15 | Defection and glomerulonephritis显示文摘 | Naicker S Fabian J Naidoo S etal | 2007 | Semin Immunopathol2007，29，4： | 1 |
| 16 | Quantitative analysis of trophoblast invasion in preeclampsia 显示文摘 | Naicker T Khedun SM Moodley J | 2003 | Acta Obstet Gynecol Scand2003，82，8： | 1 |
| 17 | Acute kidney injure associated with the use of traditional medicines显示文摘 | Luyckx VA Naicker S | 2008 | Nat Clin Pract Nephrol2008，4，12： | 1 |
| 18 | Nutritional problems associated with end - stage renal disease in the developing world 显示文摘 | Naicker S | 2002 | ArtifOr- gans2002，26，9： | 1 |
| 19 | Quantitative analysis of trophoblast invation in preeclampsia显示文摘 | Naicker T Khedun SM Moodley J | 2003 | Acta Obstet Gynecol Scand2003，82，8： | 1 |
| 20 | Nutritional problems associated with end - stage renal disease in the developing world 显示文摘 | Naicker S | 2002 | Artificial Organs2002，26，9： | 1 |
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