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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway显示文摘Oleic acid(OA),a monounsaturated fatty acid(MUFA),has previously been shown to reverse saturated fatty acid palmitic acid(PA)-induced hepatic insulin resistance(IR).However,its underlying molecular mechanism is unclear.In addition,previous studies have shown that eicosapentaenoic acid(EPA),aω-3 polyunsaturated fatty acid(PUFA),reverses PA-induced muscle IR,but whether EPA plays the same role in hepatic IR and its possible mechanism involved need to be further clarified.Here,we confirmed that EPA reversed PA-induced IR in HepG2 cells and compared the proteomic changes in HepG2 cells after treatment with different free fatty acids(FFAs).A total of 234 proteins were determined to be differentially expressed after PA+OA treatment.Their functions were mainly related to responses to stress and endogenous stimuli,lipid metabolic process,and protein binding.For PA+EPA treatment,the PA-induced expression changes of 1326 proteins could be reversed by EPA,415 of which were mitochondrial proteins,with most of the functional proteins involved in oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)cycle.Mechanistic studies revealed that the protein encoded by JUN and reactive oxygen species(ROS)play a role in OA-and EPA-reversed PA-induced IR,respectively.EPA and OA alleviated PA-induced abnormal adenosine triphosphate(ATP)production,ROS generation,and calcium(Ca^(2+))content.Importantly,H_(2)O_(2)-activated production of ROS increased the protein expression of JUN,further resulting in IR in HepG2 cells.Taken together,we demonstrate that ROS/JUN is a common response pathway employed by HepG2 cells toward FFA-regulated IR. | Yaping Sun Jifeng Wang Xiaojing Guo Nali Zhu Lili Niu Xiang Ding Zhensheng Xie Xiulan Chen Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 6 |
| 3 | Technique of Aluminum Alloy Composite by Inversion Casting显示文摘The influence of the temperature of liquid aluminum alloy, the dipping time in liquid alloy and the thickness of base strips on the solidified layer was studied during the process of producing aluminum alloy composite strips used in automobile radiator with inversion casting. It is concluded that there is welding as well as diffusion of alloying elements between the base strip and the coating. Experiments proved that the interface has a good bonding. | NaLI JinglinWEN 等 | 2002 | Journal of Materials Science & Technology2002，18，2： | 3 |
| 4 | Overexpression of Bax sensitizes prostate cancer cells to TGF-β induced apoptosis显示文摘NRP-154 is a tumorigenic epithelial cell line derived from the preneoplastic dorsal-lateral prostate of rats. These cells are exquisitely sensitive to TGF-β induced apoptosis. In contrast, we find that NRP-154 cells can sustain overexpression of exogenous Bax protein, which is different from non-tumor cells where Bax functions as a ubiquitous stimulator of apoptosis. NRP-154 cells stably overexpressing Bax show increased sensitivity to TGF-β induced apoptosis. The degree of TGF-β induced apoptosis displays high correlation with cleavage of Bax at the amino-terminus. Our data indicate that prostate cancer cells can host high levels of latent Bax which can be activated through post-translational modification. | PeiHuiLIN ZuiPAN LinZHENG NaLI DavidDANIELPOUR JianJieMA | 2005 | Cell Research2005，15，3： | 2 |
| 5 | Analysis of Influencing Factors of Technical Barriers on Information Product Exports Based on the Fuzzy AHP显示文摘To the actual situation of TBT impacting information product and according to the concept of the triangular fuzzy number, this paper forms the fuzzy matrix of factors of impacting export of information product, then uses the fuzzy AHP to analyze and rate factors. We put forward suggestions on how to keep away and surpass the technical barriers to trade in the information product enterprises. | YuyingWu NaLi | 2004 | Journal of Systems Science and Information2004，2，4： | 2 |
| 6 | A practical approach to the echocardiographic evaluation of diastolic function显示文摘 | Khouri SJ Naly GT Sun DD et a1 | 2009 | Am Soc Echoeardiogr2009，17，2： | 1 |
| 7 | Leaves of Pittosporumtobira as indicators of airborne trace element and PM10distribution in central Italy 显示文摘 | Lorenzini G Grassi C Nali C | 2006 | Atmospheric Environment2006，40，22： | 1 |
| 8 | An in vitro and in vivo investigation into the suitability of compression coated tablets of indomethacin for the treatment of rheumatoid arthritis which follow circadian rhythms显示文摘 | Songa AS Meka VS Nali SR | | 0，，03： | 1 |
| 9 | Nanocarriers:ANear-InfraredLight-TriggeredNanocarrierwithReversibleDNAValvesforIntra-cellularControlledRelease显示文摘 | NaLi ZhengzeYu WeiPan etal | 2013 | AdvFunctMater2013，23，： | 1 |
| 10 | Long-range atmospheric transport and alpine condensation of short-chain chlorinated paraffins on the southeastern Tibetan Plateau显示文摘Pristine alpine regions are ideal regions for investigating the long-range atmospheric transport and cold trapping effects of short chain chlorinated paraffins(SCCPs).The concentrations and alpine condensation of SCCPs were investigated in lichen samples collected from the southeastern Tibetan Plateau.The concentrations of SCCPs ranged from 3098 to 6999 ng/g lipid weight(lw)and appeared to have an increasing trend with altitude.For congeners,C10 dominated among all the congener groups.The different environmental behavior for different congener groups was closely related to their octanol-air partition coefficient(Koa).C10 congeners showed an increasing trend with altitude,whereas C13 congeners were negatively correlated with altitude.Volumetric bioconcentration factors(BCF)of SCCPs reached 8.71 in lichens,which were higher than other semivolatile organic compounds(SVOCs)such as organochlorine pesticides(OCPs),polybrominated diphenyl ethers(PBDEs),polychlorinated biphenyls(PCBs),and hexabromocyclododecane(HBCD).These results suggested that SCCPs were prone to accumulate in the lichen from the air and provided evidence for the role of lichens as a suitable atmospheric indicator in the Tibetan Plateau. | Huijuan Li Duo Bu Yan Gao Nali Zhu Jing Wu Xiangfeng Chen Jianjie Fu Yawei Wang Aiqian Zhang Guibin Jiang | 2021 | Journal of Environmental Sciences2021，33，1： | 1 |
| 11 | Molecular Spectroscopic Study on the Interaction between Heparinand Neutral Red显示文摘The interaction between heparin and neutral red was investigated by molecular spectroscopic methods. The change of all spectra suggested that positively charged neutral red had interacted with negatively charged heparin. The study of influence factors indicated that electrostatic force and hydrophobic bond might be involved in the interaction. The total binding number per disaccharide unit and intrinsic binding constant were obtained using Scatchard model. | LiZHANG NaLI FengLinZHAO KeAnLI | 2004 | Chinese Chemical Letters2004，15，6： | 1 |
| 12 | Synthesis of Multiaryl‐Substituted Pyridine Derivatives and Applications in Non‐doped Deep‐Blue OLEDs as Electron‐Transporting Layer with High Hole‐Blocking Ability显示文摘 | NaLi PengfeiWang Shiu‐LunLai WeiminLiu Chun‐SingLee Shuit‐TongLee ZengtaoLiu | 2010 | Adv Mater2010，，4： | 1 |
| 13 | The rate of N-demethylation of N,N-dimethylanitines and N-methylanilines by rat liver microsomes is related to their 1st ionization potential,their lipophilicity and to a steric bulk factor 显示文摘 | Galliani G Nali M Rindone B | 1986 | Xenobiotica1986，16，6： | 1 |
| 14 | Effect of chronic ozone fumigation on the photosynthetic process of poplar clones showing different sensitivity显示文摘 | Guidi L Nali C Lorenzini G | 2001 | Environment Pollution2001，113，： | 1 |
| 15 | Profilin1 facilitates staurosporine‐triggered apoptosis by stabilizing the integrin β1–actin complex in breast cancer cells显示文摘 | WantongYao XianjunYu ZhengyuFang PengYin ChaoZhao NaLi LiyingWang ZengxiaLi XiliangZha | 2012 | Journal of Cellular and Molecular Medicine2012，，4： | 1 |
| 16 | Optimization of SiO2 coatings on the surface of aluminum pigments显示文摘 | Du Bin Zhou Shisheng Li Nali | 2013 | Energy Education Science and Technology Part A: En- ergy Science and Research2013，31，1： | 1 |
| 17 | Enabling Efficient Peer-to-Peer Resource Sharing in Wireless Mesh Networks显示文摘 | C C ~NALI M E RENDA P SANTI | 2010 | IEEE Transactions on Mobile Computing2010，9，： | 1 |
| 18 | Ozone exposure affects photosynthesis of pumpkin ( Cucurbita pepo ) plants 显示文摘 | CASTAGNA A NALI C CIOMPI S | 2001 | New Philologist2001，152，2： | 1 |
| 19 | Spectrophotometric Study on the Interaction of Water with Chloranilic Acid and its Analytical Application显示文摘The reaction between chloranilic acid and water in alcohol was studied spectrophotometrically. The conditions of reaction were investigated in detail. The stable purple complex with an absorption wavelength at 530 nm was produced from the reaction between chloranilic acid and water. As a method for determination of H2O, Beer’s law was obeyed in range of 0-6.0 % or 0-8.0 % (V/V) with the detection limit of 0.13 %. The relative standard deviation (RSD) was less than 2 %. The proposed method has been applied to determination of trace amount of water in ethanol, flour and food flavoring, respectively. The recoveries of water in samples were 97~102 %. | FengLinZHAO XiLanFENG XueJingLIU NaLI KeAnLI | 2005 | Chinese Chemical Letters2005，16，7： | 1 |
| 20 | Salivary gland endoscopy: A new technique for diagnosis and treatment of sialolithiasis显示文摘 | Nalieli O Neder A Baruchin AM | 1994 | J Oral MaxillofaeeSurg1994，52，： | 1 |
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