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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Pristine mesoporous carbon hollow spheres as safe adjuvants induce excellent Th2-biased immune response显示文摘放大有免疫力的反应到抗原的一个安全、有效的助手的发展为疫苗的交货是重要的。在这研究,我们开发了太古的 mesoporous 碳是的空范围为增加有免疫力的反应的高能力的疫苗的蛋白质 nanocarriers 和安全助手。单音分散入鞘空碳范围(IMHCS ) 有的 mesostructured 200 nm, 15 nm 的大毛孔尺寸,和为 SRCA 的 2.85 厘米 3 的高毛孔体积的一种平均粒子尺寸。以便证实这试金的特性,包括属于不同 Shigella 种类和 23 个 non-Shigella 细菌的 11 个种类的 34 个种类与纯文化被检测。由 SRCA 的 Shigella flexneri 的敏感用 agarose 胶化电气泳动被评估,它是 7.3 ?> 并且 CH 4( 大约 13 ? ktonnd FE-SEM 证明 grafting 是成功的。我们然后证明 grafted 膜用吸附对牛的浆液白朊而且葡聚糖显示出优秀低犯规的性质不仅吗?? | Manasi Jambhrunkar Meihua Yu Hongwei Zhang Prasanna Abbaraju Anand Kumar Meka Antonino Cavallaro Yao Lu Neena Mitter Chengzhong Yu | 2018 | Nano Research2018，11，1： | 4 |
| 3 | Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cnhures by aetivation of the eyclooxygenaseprostaglandin pathway in stromal cells显示文摘 | Yokota T Meka CS Kouro T | 2003 | J Immunology2003，171，： | 1 |
| 4 | Adiponectin, a fat cell product, influences the earliestlymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase - prostaglandin pathway in stromal cells显示文摘 | Yokota T Reddy Meka CS Kouro T | 2003 | J lmmuao2003，171，： | 1 |
| 5 | Endurance exercise and resistancetraining in cardiovascular disease 显示文摘 | Meka N Katragadda S Cherian B | 2008 | Ther Adv Cardiovase Dis2008，2，2： | 1 |
| 6 | Optimization techniques for reactive network monitoring 显示文摘 | Bulut A Koudas N Meka A | 2009 | IEEE Transactions on Knowledge and Data Engineering2009，21，9： | 1 |
| 7 | An in vitro and in vivo investigation into the suitability of compression coated tablets of indomethacin for the treatment of rheumatoid arthritis which follow circadian rhythms显示文摘 | Songa AS Meka VS Nali SR | | 0，，03： | 1 |
| 8 | Extracorporeal shock wave therapy induces alveolar bone refeneration显示文摘 | SATHISHKUMAR S MEKA A DAWSON D | 2008 | J Dent Res2008，87，7： | 1 |
| 9 | Left Maxillary Sinus Malignant Fibrous Histiocytoma on FDG PET-CT显示文摘 | Ho L Meka M Gamble BK | 2009 | Clin Nucl Med2009，34，12： | 1 |
| 10 | Sirenomelia:MRI appearance显示文摘 | Sawhney S Jain R Meka N | | 0，，03： | 1 |
| 11 | Molecular distribution of IGF binding protein-5 in human serum显示文摘 | Baxter RC Meka S Firth SM | 2002 | J Clin Endocrinol Metab2002，87，1： | 1 |
| 12 | Genetic factors influencing recurrent pregnancy loss: lessons learnt from recent studies 显示文摘 | Dasgupta S Meka A Reddy BM | 2012 | Expert Rev Obstet Gynecol2012，7，： | 1 |
| 13 | Human pros- tate-specific transglutaminase gene: promoter cloning, tissue-specific expression, and down-regulation in meta- static prostate cancer 显示文摘 | An G Meka C S Bright S P Veltri R W | 1999 | Urology1999，54，： | 1 |
| 14 | Linezolid resistance in equential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA 显示文摘 | Meka VG Pillai SK Sakoulas G | 2004 | 3 Infect Dis2004，190，2： | 1 |
| 15 | Essential role of eyclization sequences in flavivirus RNA replication显示文摘 | KHROMYKH A A MEKA H GUYATY K J | 2001 | J Virol2001，75，14： | 1 |
| 16 | Distributed Spatial Clustering in Sensor Networks显示文摘 | Meka A Singh A | 2006 | Lecture Notes in Computer Science2006，3896，： | 1 |
| 17 | Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23s rRNA gene and loss of a single copy of rRNA显示文摘 | Meka VG Pillai SK Sakoulas G | 2004 | J Infect Dis2004，190，2： | 1 |
| 18 | Reversion to susceptibility in a linezolid resistant clinical isolate of Staphylococcus aureus显示文摘 | Meka VG Gdd HS Cooke A | 2004 | J Antimicrob Chemother2004，54，4： | 1 |
| 19 | Sirenomelia:MRI appearance显示文摘 | Sawhney S Jain R Meka N | | 0，，03： | 1 |
| 20 | The incidence of electrolyte and acid-base abnormalities in critically ill patients using point of care testing (i-STAT portable analyser) 显示文摘 | Adekola OO Soriyan OO Meka I | 2012 | Nig Q J Hosp Med2012，22，： | 1 |
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