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| 1 | Flight dynamics characteristics of canard rotor/wing aircraft in helicopter flight mode显示文摘The aerodynamic layout of the Canard Rotor/Wing(CRW) aircraft in helicopter flight mode differs significantly from that of conventional helicopters. In order to study the flight dynamics characteristics of CRW aircraft in helicopter mode, first, the aerodynamic model of the main rotor system is established based on the blade element theory and wind tunnel test results. The aerodynamic forces and moments of the canard wing, horizontal tail, vertical tail and fuselage are obtained via theoretical analysis and empirical formula. The flight dynamics model of the CRW aircraft in helicopter mode is developed and validated by flight test data. Next, a method of model trimming using an optimization algorithm is proposed. The flight dynamics characteristics of the CRW are investigated by the method of linearized small perturbations via Simulink. The trim results are consistent with the conventional helicopter characteristics, and the results show that with increasing forward flight speed, the canard wing and horizontal tail can provide considerable lift,which reflects the unique characteristics of the CRW aircraft. Finally, mode analysis is implemented for the linearized CRW in helicopter mode. The results demonstrate that the stability of majority modes increases with increasing flight speed. However, one mode that diverges monotonously,and the reason is that the CRW helicopter mode has a large vertical tail compared to the conventional helicopter. The results of the dynamic analysis provide optimization guidance and reference for the overall design of the CRW aircraft in helicopter mode, and the model developed can be used for control system design. | Honggang GAO Ao HE Zhenghong GAO Yang NA Yangping DENG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 3 |
| 2 | γ-H2AX细胞周期相关性的分析(英文)显示文摘Objective:To analyze and discuss cell cycle's correlation of γ-H2AX,so as to accumulate the data for the further studies of γ-H2AX.Methods:MOLT-4 cells,and peripheral blood lymphocytes(PBLs),with or without 48 h stimulation of phytohemagglutinin(PHA),were irradiated by ultraviolet rays(UV rays).Fluorescence-labeled γ-H2AX antibody was used to detect γ-H2AX foci at the DNA double-strand breaks(DSBs) in chromatin,DNA damage was analyzed by flow cytometry,cell cycle and cell apoptosis were detected by sub-G1 peak method,the expression of γ-H2AX was detected by Western blot.Results:With the progression of time,sub-G1 peak emerged apparently in the DNA histograms,and the cells of apoptosis increased gradually;with the progression of time,the increase of γ-H2AX emerged and firstly raised,then decreased;PBLs with 48 h stimulation of PHA entered apparently cell cycle,cells of S and G2/M phase emerged,and PBLs without stimulation of PHA did not enter cell cycle;Western blot showed the increase of the expression of γ-H2AX,and the increase also firstly raised,then decreased.Conclusion:γ-H2AX expressed in the cells of stationary phase and proliferative phase,and with the progression of time,the increase of γ-H2AX firstly raised,and then decreased. | Yangping Yue Zhenchuang Zhu Dongdong Yu Yu Deng Dan Huang Xiaolan Li Wei Xiao Deding Tao Junbo Hu Jianping Gong | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 0 |
| 3 | 金克诱导Molt-4细胞凋亡及其机制研究(英文)显示文摘Objective: To investigate the apoptosis-inducing effect of Jinke on Molt-4 cells and its possible mechanism. Methods: The Molt-4 cells were treated with different concentrations of Jinke and then cultured for necessary time. The An- nexin-V / PI method was used to detect the apoptosis rate. The cell cycle was analyzed by DNA content with flow cytometry. Double parameters analysis of cyclins / DNA was performed to detect the expression of cyclin E. API method was used to confirm the cell cycle-specific apoptosis. The expressions of Bcl-2 and Bax were detected by western blot. Results: 24 h after the treatment of 0.5, 1.0, 1.5, 2.0 and 3.0 mg/mL Jinke, the apoptosis rate of Molt-4 cells was evaluated in a concentra- tion-dependent manner, from 5.2% of the control group to 41.0% of the 3.0 mg/mL Jinke group. When the Molt-4 cells were cultured with 1.5 mg/mL Jinke, the apoptosis rate was evaluated in a time-dependent manner. DNA content analysis showed that G0/G1 phase of Molt-4 cells increased in a time-dependent manner. The expression of cyclin E increased gradually. API assay showed the apoptosis cells were almost in G0/G1 phase. Western blot showed the Bcl-2 was down-regulated and the Bax was up-regulated. Conclusion: Jinke could induce G1 phase-specific apoptosis in Molt-4 cells in time- and concentra- tion-dependent manners involving G1 phase arrest. The mechanism of apoptosis inducing effect may be related to the up- regulation of Bax and the down-regulation of Bcl-2. | Zhenchuang Zhu Yixin Tong Yangping Yue Yu Deng Dongdong Yu Wei Xiao Xiaolan Li Deding Tao Junbo Hu Jianping Gong | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，8： | 0 |
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