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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome. | Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 6 |
| 3 | Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis显示文摘Background: Gold standard for colorectal liver metastases(CRLM) remains hepatic resection(HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation(MWA), radiofrequency ablation(RFA) and HR by conducting the first network meta-analysis. Data sources: Systematic search of the literature was conducted in the electronic databases. Both updated traditional and network meta-analyses were conducted and the results were compared between them. Results: HR cohort demonstrated significantly less local recurrence rate and better 3-and 5-year diseasefree(DFS) and overall survival(OS) compared to MWA and RFA cohorts. HR cohort included significantly younger patients and with significantly lower preoperative carcinoembryonic antigen(CEA) by 10.28 ng/m L compared to RFA cohort. Subgroup analysis of local recurrence and OS of solitary and ≤3 cm CRLMs did not demonstrate any discrepancies when compared with the whole sample. Conclusions: For resectable CRLM the treatment of choice still remains HR. MWA and RFA can be used as a single or adjunct treatment in patients with unresectable CRLM and/or prohibitive comorbidities. | Paschalis Gavriilidis Keith J Roberts Nicola de’Angelis Luca Aldrighetti Robert P Sutcliffe | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 4 | Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy显示文摘The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)solution.For all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure Mg.Corrosion rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical measurements.Higher corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series alloys.These data allowed the corrosion mechanisms to be discussed. | Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère | 2019 | Journal of Magnesium and Alloys2019，7，1： | 3 |
| 5 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 6 | Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy显示文摘 | Nicolas P Turrin Serge Rivest | 2004 | Neurobiology of Disease2004，，2： | 2 |
| 7 | ICTAC Kinetics Committee recommendations for performing kinetic computations on thermal analysis data显示文摘 | Sergey Vyazovkin Alan K. Burnham José M. Criado Luis A. Pérez-Maqueda Crisan Popescu Nicolas Sbirrazzuoli | 2011 | Thermochimica Acta2011，，1： | 2 |
| 8 | Residue Determination of Two Co - administered Antibacteria Agents - cephalexin and Colistin in Calf Issues Using High - performance Liquid Chromatography and Microbiological Methods 显示文摘 | Leroy P Decolin D Nicolas S | 1989 | Pharm Bicmed Anal1989，7，12： | 1 |
| 9 | Meeting the challenges of HIV/AIDS in Southeast and East Asia显示文摘 | Nicola P Brenda SAY | 2005 | Asia Pacific Viewpoint2005，46，1： | 1 |
| 10 | Applications of WC-Co gradient materials显示文摘 | Nicolae P | 1999 | Materials Science Forium1999，，： | 1 |
| 11 | On the timing ability of mutual fund managers显示文摘 | Bollen Nicolas P B Busse Jeffrey A | 2001 | Journal of Finance Jun2001，56，3： | 1 |
| 12 | Eleetrodeposition of aluminium and aluminium/ platinum alloys from A1C13/benzyhrimethylammonium chloride room temperature ionic liquids 显示文摘 | Abbott Andrew P Eardley Christopher A Farley Nicola R S | 2001 | Journal of Applied Electrochemistry2001，31，： | 1 |
| 13 | In plane stiffness of multi- functional hierarchical honeycombs with negative Poisson s ratio sub-structures显示文摘 | YONGTAO S NICOLA M P | 2013 | Composite Structures2013，106，2： | 1 |
| 14 | Ring enhancement in ul trasmall superparamagnetic iron oxide MR imaging: A potential new sign for characterization of liver lesions 显示文摘 | Mergo P Helmeberg T Nicolas AI | 1996 | Am J Roentgenol1996，166，2： | 1 |
| 15 | The second total synthesis of diazonamide A显示文摘 | Nicolaou K C Rao P B Hao J | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 16 | Wheat cultivars vary widely in their response of grain yield and quality of short period of post anthesis heat stress显示文摘 | STONE P J NICOLAS M E | 1994 | Australian Journal of Plant Physiology1994，21，： | 1 |
| 17 | Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis 显示文摘 | Uzzan B Nicolas P Cucherat M | 2004 | Cancer Res2004，64，9： | 1 |
| 18 | A survey of the effect of high temperature during grain filling on yield and quality of 75 wheat cultivars显示文摘 | Stone P J Nicolas M E | 1995 | Aust J Agric Res1995，46，： | 1 |
| 19 | Systemic lupus erythe- matosus features in rheumatoid arthritis and their effect on over all mortality显示文摘 | Icenm Nicola P J Marad IT-Kremers H | 2009 | J Rheumatol2009，36，1： | 1 |
| 20 | Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma : A systematic review and meta-analysis 显示文摘 | Uzzan B Cohen R Nicolas P | 2006 | Crit Care Med2006，34，： | 1 |
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