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| 1 | Evidence that chronic hypoxia causes reversible impairment on male fertility显示文摘瞄准:在人的精子发生的参数和他们的复原时间上评估长期的组织缺氧的效果。方法:六男健康的山缓慢艰辛地旅行 ers 的 Seminological 参数在海水平在 normoxia 被评估。在到高度的 26 天暴露以后(从 2 000 m 到 5 600 m,古代蒙古帝国旧都遗迹远征) 一样的参数再在回到海水平以后被评估。这些参数再次在 6 个月以后在 1 个月以后然后再被评估。结果:精子计数被发现在回到海水平以后立即更低(P = 0.0004 ) 并且再在一个月以后(P = 0.0008 ) 。正常层次在 6 个月以后被到达。精子的活动性(%) 不在回到海水平以后立即显示出减小(P = 0.0583 ) ,而在 1 个月以后这减小是重要的(P = 0.0066 ) 。在 6 个月以后,到 pre-hypoxic 暴露值有恢复。在回到海以后立即增加的反常或不成熟的精子(%) 铺平(P = 0.0067 ) 然后再在 1 个月以后(P = 0.0004 ) 。在 6 个月以后,到起始的值有完全的恢复。在精液的能动精子的全部的数字被发现在回到海水平以后立即更低(P = 0.0024 ) 然后再在 1 个月以后(P = 0.0021 ) 。在 6 个月以后,到 pre-hypoxic 暴露值有恢复。结论:在 6 个月在精子发生和男富饶的生理的机制显示氧供应的影响以后,长期的组织缺氧在以前的 normoxic 条件的恢复导致精子减少的一个状态和如此的 seminological 参数的正规化。 | Vittore Verratti Francesco Berardinelli Camillo Di Giulio Gerardo Bosco Marisa Cacchio Mario Pellicciotta Michele Nicolai Stefano Martinotti Raffaele Tenaglia | 2008 | Asian Journal of Andrology2008，10，4： | 21 |
| 2 | 风力机等效载荷的评估显示文摘通过神经网络建立数学模型,利用 Multibrid M5000风力机实测的运行信号对叶片拍打弯矩、叶片弦向弯矩、塔筒弯矩和塔筒转矩的等效载荷进行了评估。同时分析了不同运行参数对评估效果的影响程度。通过与实测结果比较表明,该方法可以在避免测试风力机载荷的情况下获得载荷的评估结果,具有较高的精度,可以用来预测风力机的寿命。 | 董礼 廖明夫 Manin Kuehn Nicolai Cosack | 2008 | 太阳能学报2008，29，12： | 7 |
| 3 | 脾对比增强复合谐波超声检查对于提高霍奇金淋巴瘤病人的分期准确性:前瞻性研究显示文摘目的前瞻性比较对比增强复合谐波超声(US)、CT、18-氟脱氧葡萄糖正电子发射断层显像(FDG—PET)对初诊霍奇金淋巴瘤病人脾结节样浸润的检出效果。方法经机构审查委员会批准,病人知情同意后,在对连续100例霍奇金淋巴瘤病人进行治疗前分期,探查脾是否受累时,前瞻性比较复合谐波超声(33例病人静脉注射微泡对比剂)与CT、FDG—PET的检查结果。以上影像学手段发现恶性结节的提示征象时认为是淋巴瘤浸润;对于存在争议的病灶, | M. Picardi A. Soricelli F. Pane P. Zeppa E. Nicolai M. De Laurentiis 李瑞利(译) 沈文(校) | 2009 | 国际医学放射学杂志2009，32，4： | 5 |
| 4 | Development of a procedure for estimating the parameters of mechanistic VOC emission source models from chamber testing data显示文摘In order to evaluate the impacts of volatile organic compounds(VOCs)emissions from building materials on the indoor air quality beyond the standard chamber test conditions and test period,mechanistic emission source models have been developed in the past.However,very limited data are available for the required model parameters including the initial concentration(C_(m0)),in-material diffusion coefficient(D_(m)),partition coefficient(Kma),and convective mass transfer coefficient(k_(m)).In this study,a procedure was developed for estimating the model parameters by using VOC emission data from standard small chamber tests.In the procedure,initial values of the model parameters were refined by multivariate regression analysis of the measured emission data.To verify the procedure and estimate its uncertainty,simulated chamber test data were generated by adding 10% experimental uncertainties on the theoretical curve from the analytical solution to a mechanistic emission model.Then the procedure was applied to the generated data to estimate the model parameters.Results indicated that estimates converged to the original parameter values used for the data generation and the error of estimated parameters D_(m1)C_(m0) and K_(ma) were within±10%,±23%,and±25%of the true values,respectively.The procedure was further demonstrated by applying it to estimate the model parameters from real chamber test data.Wide application of the procedure would result in a database of mechanistic source model parameters for assessing the impact of VOC emissions on indoor pollution load,which are essential input data for evaluating the effectiveness of various indoor air quality(IAQ)design and control strategies as well as the energy required for meeting given IAQ requirements. | Zhenlei Liu Andreas Nicolai Marc Abadie Menghao Qin John Grunewald Jianshun Zhang | 2021 | Building Simulation2021，14，2： | 4 |
| 5 | The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis显示文摘 | Patrick M. Smith Michael R. Howitt Nicolai Panikov Monia Michaud Carey Ann Gallini Mohammad Bohlooly-Y Jonathan N. Glickman Wendy S. Garrett | 2013 | Science . 2013 (6145)2013，，： | 3 |
| 6 | Long-term Consequences of Postoperative Cognitive Dysfunction显示文摘 | Jacob Steinmetz Karl Bang Christensen Thomas Lund Nicolai Lohse Lars S. Rasmussen | 2009 | Anesthesiology2009，，3： | 3 |
| 7 | 托普索合成氨技术综述显示文摘回顾了合成氨发展的百年历程;介绍了托普索公司发明的侧烧管式转化炉、径向流动氨合成塔以及氨合成催化剂等合成氨工艺技术;展望了合成氨工艺技术的发展前景。 | Stephanie Michelle King Nicolai Petersen Ib Dybkjr | 2014 | 化肥设计2014，52，3： | 3 |
| 8 | 现代功率模块及器件应用技术(2)显示文摘现代的快速开关器件要求采用快速的二极管作为续流二极管。在每一次开关的开通过程中,续流二极管由导通切换到截止状态。这一过程要求二极管具有软恢复的特性。但是,在很长一段时期里,忽视了快速二极管的作用,使得开关器件工作频率的提高受到了限制。在过去的几年中,它又受到了高度的重视,特别是通过改善它的反向恢复特性而得到了长足的发展。 | Ulrich Nicolai Tobias Reimann 李毅 魏宇浩 | 2005 | 电源技术应用2005，8，2： | 3 |
| 9 | Pectin May Hinder the Unfolding of Xyloglucan Chains during Cell Deformation: Implications of the Mechanical Performance of Arabidopsis Hypocotyls with Pectin Alterations显示文摘种房间墙,象大量的其它一样生物材料,是自然增强纤维的合成材料。他们的机械性质自己高度依赖于生硬含纤维的阶段和软矩阵阶段的相互影响并且在矩阵变丑上。用特定的 Arabidopsis thaliana 异种,我们与改变的 xyloglucan 和果胶作文在胚轴的主要房间墙中学习了矩阵集会的机械角色。标准 microtensile 测试和周期的装载协议象少些展出 50% 的 qua2 一样与影响 RGII 硼酸盐 diester 交叉结合和妨碍的 xyloglucan fucosylation 在 mur1 胚轴上被执行 homogalacturonan 与相比野类型。作为控制,野类型的植物(Col-0 ) 和在果胶网络展出特定的 xyloglucan fucosylation 和没有差别的 mur2 被利用。在标准张力的测试,有果胶改变的异种的胚轴的最终的压力层次(张力的力量)(mur1, qua2 ) 是相当未受影响的,而他们的张力的僵硬显著地与 Col-0 相比被减少。周期的装载测试显示了一在首先拉紧然而,其度为 mur1 和 qua2 胚轴是高得多的期间在第一个周期和塑料变丑以后所有胚轴使硬。基于机械数据和当前的房间墙模型,在纤维素纤丝之间的合拢的 xyloglucan 链可以趋于在胚轴拉紧期间展开,这被假定。这回答被几何限制可能由于果胶刚硬妨碍。 | Willie Abasolo Michaela Eder Kazuchika Yamauchi Nicolai Obel Antje Reinecke Lutz Neumetzler John W.C. Dunlop Gregory Mouille Markus Pauly Herman Hofte Ingo Burgert | 2009 | Molecular Plant2009，2，5： | 2 |
| 10 | Clinical outcome after orbital floor fracture reduction with special regard to patient's satisfaction显示文摘Purpose: Primary reconstruction via transconjunctival approach is a standardized treatment option for orbital floor fractures. The aim of this study was to compare the findings of specific ophthalmologic assessment with the patient's complaints after fracture reduction. Methods: A retrospective medical chart analysis was performed on patients who had undergone transconjunctival orbital floor fracture reduction for fracture therapy with resorbable foil (ethisorb sheet or polydioxanone foil). A follow-up assessment including ophthalmological evaluation regarding visual acuity (eye chart projector), binocular visual field screening (Bagolini striated glasses test) and diplopia (cover test, Hess screen test) was conducted. Additionally, a questionnaire was performed to assess patients' satisfaction. Results: A total of 53 patients with a mean follow-up of 23 months (ranging from 11 to 72) after surgical therapy were included. Diplopia was present preoperatively in 23 (43.4%) and reduced in follow-up examination (n = 12, 22.6%). Limitations in ocular motility reduced from 37.7% to 7.5%. The questionnaire about the patient's satisfaction revealed excellent outcomes in relation to the functional and esthetical parameters. Conclusion: Transconjunctival approach is a safe approach for orbital fracture therapy. Postoperative diplopia is nearly never perceptible for the individual and differs to pathologic findings in the ophthalmic assessment. | Stefan Hartwig Marie-Christine Nissen Jan Oliver Voss Christian Doll Nicolai Adolphs Max Heiland Jan Dirk Raguse | 2019 | Chinese Journal of Traumatology2019，22，3： | 2 |
| 11 | [^sup 18^F]FDG-PET-CT for early monitoring of tumor response: when and why显示文摘 | Storto G Nicolai E Salvatore M | 2009 | The Quarterly Journal of Nuclear Medicine and Molecular Imaging2009，，2： | 2 |
| 12 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 13 | The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis显示文摘 | Patrick M. Smith Michael R. Howitt Nicolai Panikov Monia Michaud Carey Ann Gallini Mohammad Bohlooly-Y Jonathan N. Glickman Wendy S. Garrett | 2013 | 2013 (6145)2013，，6145： | 2 |
| 14 | 高效经济的涤棉混纺织物染色后处理显示文摘涤棉混纺织物常规染色工艺工序多,耗时长,加工成本高。为提高生产效能,降低工艺成本,德国司马化学公司(ZSM)开发了ZETESAL NPC染色后处理剂,作为新REACTIVEF lash染色体系的一个部分。该体系是经济的加工工艺与高牢度品质的结合,且生产稳定安全性高。 | Wickert Nicolai Schnfeld Andreas | 2007 | 印染2007，33，10： | 2 |
| 15 | Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids显示文摘Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid(FSL) constructs that can be gently inserted into the virus membrane. We assessed whether labeling with fluorescent(fluo-Ad-DOPE) or biotin-labeled(biot-CMG2-DOPE) probes has any deleterious effect on influenza virus hemagglutinin(HA) receptor specificity, neuraminidase(NA) activity, or replicative ability in vitro. Our data clearly show that neither construct significantly affected influenza virus infectivity or viral affinity to sialyl receptors. Neither construct influenced the NA activities of the influenza viruses tested, except the A/Puerto Rico/8/34(H1N1) strain. Our data indicate that lipid labeling provides a powerful tool to analyze influenza virus infection in vitro. | Natalia A Ilyushina Evgeny S Chernyy Elena Y Korchagina Aleksra S Gambaryan Stephen M Henry Nicolai V Bovin | 2014 | Virologica Sinica2014，29，4： | 2 |
| 16 | Effect of terbium gallium garnet crystal orientation on the isolation ratio of a Faraday isolator at high average power显示文摘 | Efim Khazanov Nicolay Andreev | 2002 | Appl Opt2002，41，3： | 2 |
| 17 | New human resource management practices, complementarities and the impact on innovation performance显示文摘 | Keld Laursen Nicolai J. Foss | 2003 | Cambridge Journal of Economics2003，，： | 2 |
| 18 | Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update显示文摘Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe form.The use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still limited.We present our results and discuss the significance of ECMO in treating burn patients.Methods:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was performed.Demographic,clinical,and outcome data were collected and analyzed.Results:Eight burn patients were treated at our institution with ECMO in the designated time period.Of these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±21.Seven patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 mmHg.ECMO duration was 388±283 h.Three patients died from severe sepsis while five patients survived to hospital discharge.Conclusions:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ARDS.Consequently,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome. | Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk Buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt | 2019 | Burns & Trauma2019，7，1： | 2 |
| 19 | Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases显示文摘 | Andreas M. Stark Kerrin Tongers Nicolai Maass H. Maximilian Mehdorn Janka Held-Feindt | 2005 | Journal of Cancer Research and Clinical Oncology2005，，3： | 2 |
| 20 | 环境变化背景下北极生物的多样性、分布及其适应性显示文摘生物个体是对气候变化和紫外线B(UV-B)辐射变化产生反应的基础,而且这种反应会在各种时间尺度上发生。北极地区的动物、植物以及微生物种类的多样性从表面上看是低的,而且从北方针叶林到极地荒漠逐渐减少,但其原始物种却很丰富。与这种物种多样性随纬向梯度减少的趋势相反,一些空间分布范围很广的单一优势物神的优势度则呈增长趋势。全球气候变暖可能会减少该地区的物种多样性,并限制到这些物种的分布范围,尤其是在该地区生物分布的北部边缘,一些极地特有的动物和植物种类会面临着灭绝的危险。最有可能侵入苔原地带的物种是那些目前生存在极地外缘的北方地区生物。许多植物都具有自身的特征使它们能够在以下环境中生存;短暂的无冰雪覆盖的生长季节,低的太阳高度角,永久冻结地带及低的土壤温度,贫乏的养分获取条件以及极少的物理扰动。以上这些特征有些可能会限制当地物种对气候变暖的反应,但其最主要的因素是这些物种与那些潜在的入侵物种相比缺乏竞争能力。北极地区陆生动物拥有许多适应特性,这使它们能够适应北极地区剧烈的温度变化。许多动物通过冬眠或迁移来逃避极地地区的恶劣天气和资源短缺。北极地区动物生存的生物环境则相对简单:几乎没有天敌、竞争者、疾病、寄生生物,但同时食物资源也很短缺。极地陆生动物可能对由气候变化带来的温暖而干旱的夏季非常不适应,这种变化将会影响到动物的迁移路线、途中栖息地,并会改变冬季积雪的状况和冻融的循环过程。气候变化还会改变动物繁殖和发育的季节,并会引来新的竞争者、捕食者、寄生生物以及疾病等。极地微生物也能很好地适应该地区的气候:一些微生物甚至在-39℃的低温下还能进行代谢活动。蓝藻细菌和藻类生物有着很广泛的适应策略,这能够使它们避免(至少可以减少)紫外线的伤害。微生物能够忍受许多环境条件,而且其生长周期很短,这些特点将使它们能很快适应新的生存环境。与此形成对比的是,极地植物和动物很可能通过改变其分布范围而不是积极的生物进化来适应环境的变暧。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Heikki Henttonen Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 何永涛 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 2 |
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