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| 1 | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease显示文摘A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed models.Although these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease. | Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 2 | Association of serum lipid levels with diabetic retinopathy显示文摘AIM: To assess the association between serum lipids and diabetic retinopathy (DR). · METHODS: Sixty -one diabetic patients without retinopathy (NDR), 55 diabetic patients with non - proliferative retinopathy (NPDR) and 75 diabetic patients with proliferative retinopathy (PDR) according to ETDRS grading scale were enrolled in this study. Total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglyceride values were compared between the groups. ·RESULTS: The groups were well-balanced in terms of age and gender (P =0.071, P =0.265 respectively). The mean HbA1c values were significantly lower in NDR group than the NPDR and PDR groups(P =0.004, P =0.009 respectively). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the groups (P =0.693, P =0.774, P =0.644, P = 0.910 and P =0.967 respectively, one way ANOVA). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the patients with ME and patients without ME(P =0.622, P =0.113, P =0.955, P =0.735 and P =0.490 respectively, t -test). The mean blood glucose significantly correlated with total cholesterol (r =0.173, P =0.017) and LDL (r =0.190, P = 0.008). The mean HbA1c significantly correlated with total cholesterol (r =0.158, P =0.030) and triglyceride (r =0.148, P =0.042). ·CONCLUSION: Serum lipid levels were not significantly associated with the severity of DR or existence of ME despite the significant correlation between the mean blood glucose, HbA1c and total cholesterol. | Ebru Nevin Cetin Yunus Bulgu Seyfullah Ozdemir Senay Topsakal Fulya Akln Hulya Aybek Cem Ylldlrlm | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 14 |
| 3 | A data-driven method for syndrome type identification and classification in traditional Chinese medicine显示文摘The efficacy of traditional Chinese medicine(TCM) treatments for Western medicine(WM) diseases relies heavily on the proper classification of patients into TCM syndrome types.The authors developed a data-driven method for solving the classification problem,where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data.The new method is a generalization of latent class analysis(LCA),which has been widely applied in WM research to solve a similar problem,i.e.,to identify subtypes of a patient population in the absence of a gold standard.A well-known weakness of LCA is that it makes an unrealistically strong independence assumption.The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA.This new method consists of six steps:data collection,symptom co-occurrence pattern discovery,statistical pattern interpretation,syndrome identification,syndrome type identification and syndrome type classification.A software package called Lantern has been developed to support the application of the method.The method was illustrated using a data set on vascular mild cognitive impairment. | Nevin Lianwen Zhang Chen Fu Teng Fei Liu Bao-xin Chen Kin Man Poon Pei Xian Chen Yun-ling Zhang | 2017 | Journal of Integrative Medicine2017，15，2： | 11 |
| 4 | 强化赖氨酸面粉对人群营养及免疫功能的影响显示文摘 | 赵文华 翟凤英 张丁 安云庆 刘颖 何宇纳 葛可佑 Nevin S.Scrimshaw | 2001 | 中国食物与营养2001，7，3： | 9 |
| 5 | Identification and classification of traditional Chinese medicine syndrome types among senior patients with vascular mild cognitive impairment using latent tree analysis显示文摘OBJECTIVE: To treat patients with vascular mild cognitive impairment(VMCI) using traditional Chinese medicine(TCM), it is necessary to classify the patients into TCM syndrome types and to apply different treatments to different types. In this paper, we investigate how to properly carry out the classification for patients with VMCI aged 50 or above using a novel data-driven method known as latent tree analysis(LTA).METHOD: A cross-sectional survey on VMCI was carried out in several regions in Northern China between February 2008 and February 2012 which resulted in a data set that involves 803 patients and 93 symptoms. LTA was performed on the data to reveal symptom co-occurrence patterns, and the patients were partitioned into clusters in multiple ways based on the patterns. The patient clusters were matched up with syndrome types, and population statistics of the clusters are used to quantify the syndrome types and to establish classification rules.RESULTS: Eight syndrome types are identified: Qi deficiency, Qi stagnation, Blood deficiency, Blood stasis, Phlegm-dampness, Fire-heat, Yang deficiency, and Yin deficiency. The prevalence and symptom occurrence characteristics of each syndrome type are determined. Quantitative classification rules are established for determining whether a patient belongs to each of the syndrome types.CONCLUSION: A solution for the TCM syndrome classification problem for patients with VMCI and aged 50 or above is established based on the LTA of unlabeled symptom survey data. The results can be used as a reference in clinic practice to improve the quality of syndrome differentiation and to reduce diagnosis variances across physicians. They can also be used for patient selection in research projects aimed at finding biomarkers for the syndrome types and in randomized control trials aimed at determining the efficacy of TCM treatments of VMCI. | Chen Fu Nevin Lianwen Zhang Bao-xin Chen Zhou Rong Chen Xiang Lan Jin Rong-juan Guo Zhi-gang Chen Yun-ling Zhang | 2017 | Journal of Integrative Medicine2017，15，3： | 4 |
| 6 | Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis显示文摘 | Amira A.M. Adly Eman A. Ismail Nevine G. Andrawes Marwa A. El-Saadany | 2013 | Cytokine2013，，： | 2 |
| 7 | Characterization of Kiwifruit Xyloglucan显示文摘Structural characteristics of xyloglucan are constant in the pericarp cell walls of kiwifruit (Actinidia deliciosa) throughout fruit enlargement and maturation. Most of the xyloglucan (XG) persists in the cell walls of ripe kiwifruit. XG from the pericarp tissues of 36-h ethylene-treated kiwifruit was extracted as hemicellulose Ⅱ (HC-Ⅱ) with 4.28 M KOH containing 0.02% NaBH4, and purified using iodine precipitation and subsequent anion-exchange chromatography. This purifying protocol increased XG purity from 50 mol% in HC-Ⅱ fraction to 62 mol% in the purified XG powder. The molar ratio of glucose: xylose: galactose: fucose in the purified XG was 10: 6.9: 2.1: 0.3. Gel permeation chromatography indicated that purified XG had an average molecular-mass of 161 KDa, a value that exceeds the 95 KDa Mr determined for total polymeric sugars. Sugar linkage analysis confirmed the lack of fucose in the kiwifruit XG, but a small amount of arabinoxylan and low Mr glucomannan remained associated with this fraction. | Xingjun Li Naoki Sakurai Donald J. Nevins | 2009 | Journal of Integrative Plant Biology2009，51，10： | 2 |
| 8 | 薄膜包衣技术在保护引湿性紫锥菊提取物中的应用显示文摘 | 于海春 Kevin Hughes Nevin Crake Tom Farrell Ngoc Do | 2008 | 中国药学杂志2008，43，9： | 2 |
| 9 | Impact of MRI on Treatment Plan and Fracture Classification of Tibial Plateau Fractures显示文摘 | Stephan V. Yacoubian Russell T. Nevins Julian G. Sallis Hollis G. Potter Dean G. Lorich | 2002 | Journal of Orthopaedic Trauma2002，，9： | 2 |
| 10 | Mental health of parents of children with autism spectrum disorder during COVID-19 pandemic: A systematic review显示文摘BACKGROUND Children diagnosed with autism spectrum disorder(ASD)may have great difficulties when their routines change,and this may affect the psychological wellbeing of their parents.For this reason,it is important to examine studies that address the mental health of parents in order to adapt to the coronavirus disease 2019(COVID-19)pandemic.AIM To determine the mental health status of parents with children diagnosed with ASD in the COVID-19 pandemic.METHODS The study,which is a systematic review,was conducted between December 15,2020 and December 30,2020 by scanning articles in English.The Scopus,Science Direct,PubMed,Cochrane,Web of Science,and Google Scholar databases were used for scanning.The keywords COVID-19 AND(“autism”OR“autistic”OR“autism spectrum disorder”)AND parent AND(“mental health”OR“anxiety”OR“stress”)were used in the search process.The inclusion criteria in the study were findings regarding the mental health of parents with children diagnosed with ASD in the COVID-19 pandemic,addressing their anxiety and stress situations,being a research article,and accessing the full text of the article.RESULTS In the study,a total of 6389 articles were reached,and the full texts of 173 articles were evaluated for eligibility.After the articles excluded by the full-text search were eliminated,12 studies involving 7105 parents were included in the analysis.The findings obtained from the articles containing data on mental health in the COVID-19 pandemic of parents with children with autism spectrum disorder were discussed in three groups.These were findings on the experiences of parents with children with ASD in the COVID-19 pandemic regarding the areas where parents with children with ASD need support in the COVID-19 pandemic and methods of coping with the COVID-19 pandemic for parents with children with ASD.In the systematic review,it was determined that the anxiety and stress of the parents increased,they needed more support compared to the pre-pandemic period,and they had difficulty coping.CONCLUSION In this systematic review,it was concluded that the COVID-19 pandemic negatively affected the mental health of the parents of children with ASD. | Büşra Yılmaz Merve Azak NevinŞahin | 2021 | World Journal of Psychiatry2021，11，7： | 2 |
| 11 | Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite显示文摘AIM:To compare the potential protective effects of epigallocatechin gallate(EGCG) and ellagic acid(EA) in an experimental cataract model.●METHODS:Twenty-eight Spraque-Dawley rat pups were assigned into four groups.All the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th days.Rats in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/(kg·d) saline solution,50 mg/(kg·d) EGCG and 200 mg/(kg·d) EA,respectively.The reduced glutathione(GSH) and malondialdehyde(MDA) levels,total antioxidant status(TAS) and total oxidant status(TOS) in lens supernatants were measured.RESULTS:The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group(P<0.001).The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group(P<0.001).CONCLUSION:EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress. | Irfan Ergen Burak Turgut Nevin Ilhan | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 2 |
| 12 | Sea level change along the Black Sea coast from satellite altimetry, tide gauge and GPS observations显示文摘Sea level change affects human living conditions,particularly ocean coasts.However,sea level change is still unclear along the Black Sea coast due to lack of in-situ measurements and low resolution satellite data.In this paper,sea level change along the Black Sea coast is investigated from joint satellite altimetry,tide gauge(TG) and Global Positioning System(GPS) observations.The linear trend and seasonal components of sea level change are estimated at 8 TG stations(Amasra,Igneada,Trabzon-Ⅱ,Sinop,Sile,Poti,Tuapse,and Batumi) located along the Black Sea coast,which are compared with Satellite Altimetry and GPS.At the tide gauge stations with long-term records such as Poti(about 21 years) and Tuapse(about 19 years),the results obtained from the satellite altimetry and tide gauge observations show a remarkably good agreement.While some big differences are existed between Satellite Altimetry and TG at other stations,after adding vertical motion from GPS,correlation coefficients of the trend have been greatly improved from 0.37 to 0.99 at 3co-located GPS and TG stations(Trabzon-Ⅱ,Sinop and Sile). | Nevin B. Avsar Shuanggen Jin Hakan Kutoglu Ookhan Ourbuz | 2016 | Geodesy and Geodynamics2016，7，1： | 2 |
| 13 | Gliomatosis cerebri显示文摘 | | 1938 | Brain1938，61，2： | 1 |
| 14 | Evaluation of periodontal regeneration following grafting intrabony defects with bio2oss collagen:a human histologic report显示文摘 | NEVINS ML CAMELO M LYNCH SE | 2003 | Int J Periodontics Restorative Dent2003，23，1： | 1 |
| 15 | Carcinome of the gallbladder: staging treatment and prognosis显示文摘 | Nevin Je Moran TJ Kays | 1976 | Cacner1976，37，： | 1 |
| 16 | Exergy transfer in a porous rectangular channel显示文摘 | Irfan Kurtbas Nevin Celik lbrahim Dinner | 2010 | Energy2010，35，： | 1 |
| 17 | Air and Oxy-Fuel Combustion Be- haviour of Petcoke/Lignite Blends 显示文摘 | Nur S Y Nevin S | 2012 | Fuel2012，92，1： | 1 |
| 18 | Microbial electrosynthesis: feeding microbes electricity to convert carbon dioxide and water to multicarbon extracellular organic compounds 显示文摘 | Nevin KP Woodard TL Franks AE Summers ZM Lovley DR | 2010 | mBio2010，1，00： | 1 |
| 19 | Effect of unplanned extubation on outcome of mechanical ventilation显示文摘 | Epstein SK Nevins ML Chung J | 2000 | Am J Respir Crit Care Med2000，161，6： | 1 |
| 20 | Electrosynthesis of Organic Compounds from Car- bon Dioxide Is Catalyzed by a Diversity of Aceto- genic Microorganisms 显示文摘 | Nevin K P Hensley S A Franks A E | 2011 | Appl Environ Microbi- ol2011，77，9： | 1 |
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