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| 1 | 滋养细胞组织 GATA-3表达:445例免疫组化及其诊断应用分析显示文摘GATA-3主要表达在乳腺癌和尿路上皮癌,而在正常或病变滋养细胞组织中的表达报道甚少。作者选取445例正常/病变滋养细胞组织及其肿瘤进行 GATA-3免疫组化评估,根据着色强弱标记为(-~-),探讨GATA-3在下列组织中的表达意义。这些组织包括孕囊/中晚期妊娠胎盘/异位妊娠、葡萄胎、胎盘结节、正常/异常植入部位、绒毛膜癌、上皮样滋养细胞肿瘤、胎盘滋养细胞肿瘤、非典型平滑肌瘤(含平滑肌肉瘤)、子宫颈和肺的鳞状细胞癌。 | Natalie B Allen M G Ie-Ming S 许文静 余英豪 | 2015 | 临床与实验病理学杂志2015，31，9： | 11 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Thermal matu- rity of the Barnett Shale determined from welll oganalysis显示文摘 | Hank Zhao Natalie B Givens Brad Curtis | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 4 | Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions 显示文摘 | Hamby CV Felding-Habermann B | 1997 | Cancer Res1997，57，8： | 1 |
| 5 | Glutamine attenuates endotoxin-induced lung metabolic dysfunction:potential role of enhanced heat shock protein 70显示文摘 | Kristen D S Natalie S Anirban B | 2005 | Nutrition2005，21，： | 1 |
| 6 | Thermal maturity of the Barnett Shale determined from well-log analysis 显示文摘 | Hank Z Natalie B G Brad C | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 7 | Metabolic syndrome: at the crossroads of cardiorenal risk显示文摘 | Natali A Pucci G Boldrini B | 2009 | J Nephrol2009，22，1： | 1 |
| 8 | Thermo-dynamic properties of cubane显示文摘 | Kybett B D Carroll S Natalis P | 1966 | J Arh Chem Soc1966，88，3： | 1 |
| 9 | Comparison of two andthree-dimensional analyses of interface fracture dataobtained from Brazilian disk specimens显示文摘 | Leslie B S Natalie K Fliesher A | 2010 | InternationalJournal of Structural Integrity2010，1，1： | 1 |
| 10 | The Flipped Classroom Strategy: What is it and How Can it Best be Used? 显示文摘 | Milman Natalie B | 2012 | Distance Learning2012，，9： | 1 |
| 11 | Simultaneous Nitrification and Denitrification Using Stored Substrate (PHB) as the Electron Donor in an SBR显示文摘 | KATIE A T NATALIE B RALF C R | 2003 | Biotechnol Bioeng2003，83，： | 1 |
| 12 | Foot length in fetuses with abnormal growth显示文摘 | NATALIE B M CANDE V A JOHN C M | 2000 | J Ultrasound Med2000，19，： | 1 |
| 13 | Improvements of atherosclerosis and hepatic oxidative stress are independent of exercise intensity in LDLr(-/-) mice 显示文摘 | Teodoro B G Natali A J Fernandes S A | 2012 | Atheroscler Thromb2012，19，10： | 1 |
| 14 | Anti - inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes 显示文摘 | Morgantini C Natali A Boldrini B | 2011 | Diabetes2011，60，10： | 1 |
| 15 | Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies显示文摘 | Wilson B S Imai K Natali P G | 1981 | Int J Cancer1981，28，3： | 1 |
| 16 | Living on a surface:swarming and biofilm formation显示文摘 | Natalie V Kristien B Bachaspatimayum D | 2008 | Cell2008，16，： | 1 |
| 17 | Fractured hydrother- mal dolomite reservoirs in the Devonian Dundee Formation of the cen- tral Michigan Basin 显示文摘 | Luczaj A J Harrison I William B Natalie S W | 2006 | AAPG Bulletin2006，90，11： | 1 |
| 18 | Crosstalk between the canonical NF-[kappa]B and Notch signaling pathways inhibits Ppar[gamma] expression and promotes pancreatic cancer progression in mice显示文摘 | Maniati Eleni Bossard Maud Cook Natalie Candido Juliana B Emami-Shahri Nia Nedospasov Sergei A Balkwill Frances R Tuveson David A Hagemann Thorsten | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 19 | Fractured hydrothermal dolomite reservoirs in the Devonian Dundee Formation of the central Michigan basin显示文摘 | Luczaj A J Harrison B W Natalie S W | 2006 | AAPG Bulletin2006，90，11： | 1 |
| 20 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
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