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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 3 | Interleukin-1βinduces human cementoblasts to support osteoclastogenesis显示文摘Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts.Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin(IL)-1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin.The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology. Gene expression of primary human cementoblasts(p HCB) was compared with a human cementoblast cell line(HCEM). The p HCBs were analyzed for their expression of IL-1 receptors as well as of receptor activator of nuclear factor kappa-B ligand(RANKL) and osteoprotegerin(OPG). In a co-culture system consisting of osteoclast precursors(blood monocytes) and p HCBs, the formation of osteoclasts and their resorptive activity was assessed by osteo-assay and ivory slices. The cells obtained after a 120 min enzyme digestion expressed the highest level of bone sialoprotein, similar to that of HCEM. This fraction of isolated cells also shared a similar expression pattern of IL-1 receptors(IL1-R1 and IL1-R2). Treatment with IL-1β potently upregulated RANKL expression but not of OPG. p HCBs were shown to induce the formation of functional osteoclasts. This capacity was significantly stimulated by pretreating the p HCBs with IL-1β prior to their co-culture with human blood monocytes. Our study demonstrated that cementoblasts have the capacity to induce osteoclastogenesis, a capacity strongly promoted by IL-1β. These results may explain why osteoclasts can be formed next to the root of teeth. | nam c-n huynh vincent everts prasit pavasant ruchanee s ampornaramveth | 2017 | International Journal of Oral Science2017，9，4： | 5 |
| 4 | Mimicking unfolding motion of a beetle hind wing显示文摘This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. | MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung GOO Nam S | 2009 | Chinese Science Bulletin2009，54，14： | 3 |
| 5 | Effect of InterlamellarSpacing on Cementite Dissolution during Wire Drawing ofPearlitic Steel Wires 显示文摘 | Nam W J Bae C M Oh S J | 2000 | Scripta Mater2000，42，： | 2 |
| 6 | Effectiveness and safety of ureteroscopy in pregnant women: a comparative study显示文摘 | Yasar Bozkurt Haluk Soylemez Murat Atar Ahmet Ali Sancaktutar Necmettin Penbegul Nam?k Kemal Hatipoglu Mehmet Nuri Bodakc? Mehmet S?dd?k Evsen | 2013 | Urolithiasis2013，，1： | 2 |
| 7 | Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana显示文摘 | OH S A PARK J H LEE G I PACK K H PARK S K NAM H G | 1997 | Plant Journal1997，12，3： | 1 |
| 8 | The study of seepage forces acting on the tunnel lining and tunnel face in shallow tunnels显示文摘 | Lee I M Nam S W | 2001 | Tunneling and Underground Space Technology2001，16，： | 1 |
| 9 | Transmit power allocation for a modified V-BLAST system显示文摘 | Nam S H Shin O S Lee K B | 2004 | IEEE Transactions on Communications2004，52，7： | 1 |
| 10 | Correlation between characteristics of grain boundary carbides and creep-fatigue properties in AISI 321 stainless steel 显示文摘 | Min K S Nam S W | 2003 | Journal of Nuclear Materials2003，322，： | 1 |
| 11 | Does neoadjuvant chemotherapy increase optimal cytoreduction rate in advanced ovarian cancer? Meta-analysis of 21 studies 显示文摘 | Kang S Nam BH | 2009 | Ann Surg Oncol2009，16，8： | 1 |
| 12 | Strain rate dependence of deformation behavior of high-nitrogen austenitic steels显示文摘 | KIM Y S NAM S M KIM S J | 2007 | Journal of Materials Processing Technology2007，，： | 1 |
| 13 | Effect of interlamellar spacing on cementite dissolution during wire drawing of pearlitic steel wires显示文摘 | Nam W J Bae C M Oh S J | 2000 | Scripta Mater2000，42，5： | 1 |
| 14 | Environment- friendly, biodegradable composites using ramie fibers and Soy Protein Concentrate (SPC) resin 显示文摘 | NAM S NETRAVALI A N | 2006 | Fibers and Polymers2006，7，4： | 1 |
| 15 | Liner stresses in deep tunnelsbelow the water table显示文摘 | NAM S W BOBET A | 2006 | Tunnelling and UndergroundSpace Technology2006，21，6： | 1 |
| 16 | Decomposition of volatile organic compounds and nitric oxide by non thermal plasma discharge process显示文摘 | Mok Y S Nam C M Cho M H | 2002 | IEEE Transaction on Plasma Science2002，30，1： | 1 |
| 17 | Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes显示文摘 | Nam K S Jo Y S Kim Y H | 2001 | Life sci2001，69，2： | 1 |
| 18 | A feedback linearizing control scheme for a PWM converter-inverter having a very small DC-link capacitor 显示文摘 | Jung J Lira S Nam K | 1999 | IEEE Transactions on Industry Ap- plications1999，35，5： | 1 |
| 19 | Rapid detection of Enter- obactersakazakii using TaqMan real - time PCR assay 显示文摘 | Kang S E Nam Y S Hong K W | 2007 | J Microbiol Biotechnol2007，17，3： | 1 |
| 20 | A high performance solenoid-type MEMS inductor 显示文摘 | SEOK S NAM C CHOI W | 2001 | J Semicond Tech Sci2001，1，： | 1 |
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