|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 2 | Management of chronic heart failure in the older population显示文摘长期的心失败(CHF ) 是为超过 65 岁的那些的住院的领先的原因并且代表重要临床、经济的负担。关于医院重新接纳的一半与与 CHF 联系的合作病态, polypharmacy 和残疾有关。而且, CHF 也与平均的以差的预后有庞大的费用 33%-35% 的年死亡。当多于有 CHF 的病人的一半是超过 75 年,很临床的试用与 61 年的吝啬的年龄包括了更年轻的病人时。不适当的数据为供应商使治疗决定挑战性。更旧的 CHF 病人更经常是女性的,有不太心血管的疾病和联系风险非心血管的条件和心脏舒张的机能障碍的因素,而是更高的率。,有减少的喷射部分, ischemic 心疾病,和它的风险因素的 CHF 的流行与年龄衰退非心脏的合作病态的流行痴呆,贫血症和恶意例如长期的肾的失败,与年龄增加。糖尿病和高血压在有冠的心疾病的女人之中特别地作为 CHF 的预言者在最强壮的风险因素之中。这份评论报纸将在更旧的人口为 CHF 评价集中于特定的考虑。管理策略将被考察,包括 non-pharmacologic, pharmacologic,优秀照顾指示物,在照顾转变并且最后的优秀改进, end-of-life 问题。辩解的照顾应该是为在整个疾病轨道上的一个全面照顾计划的一条学科交差的队途径的不可分的部分。另外,脆弱贡献对存在风险模型增长的珍贵预示的卓见并且在为他们的病人定义最佳的照顾小径帮助临床医生。 | Nahid Azad Genevieve Lemay | 2014 | Journal of Geriatric Cardiology2014，11，4： | 26 |
| 3 | Comparison of microstructure and mechanical properties of titanium/ steel composite plates by two manufacturing processes显示文摘 | Xuan Yang Chang-gen Shi Yu-heng Ge Md Nahid Hasan Sabuj | 2018 | Journal of Iron and Steel Research(International)2018，25，3： | 7 |
| 4 | Exercise preconditioning exhibits neuroprotective effects on hippocampal CA1 neuronal damage after cerebral ischemia显示文摘Recent evidence has suggested the neuroprotective effects of physical exercise on cerebral ischemic injury. However, the role of physical exercise in cerebral ischemia-induced hippocampal damage remains controversial. The aim of the present study was to evaluate the effects of pre-ischemia treadmill training on hippocampal CA1 neuronal damage after cerebral ischemia. Male adult rats were randomly divided into control, ischemia and exercise + ischemia groups. In the exercise + ischemia group, rats were subjected to running on a treadmill in a designated time schedule(5 days per week for 4 weeks). Then rats underwent cerebral ischemia induction th rough occlusion of common carotids followed by reperfusion. At 4 days after cerebral ischemia, rat learning and memory abilities were evaluated using passive avoidance memory test and rat hippocampal neuronal damage was detected using Nissl and TUNEL staining. Pre-ischemic exercise significantly reduced the number of TUNEL-positive cells and necrotic cell death in the hippocampal CA1 region as compared to the ischemia group. Moreover, pre-ischemic exercise significantly prevented ischemia-induced memory dysfunction. Pre-ischemic exercise mighct prevent memory deficits after cerebral ischemia through rescuing hippocampal CA1 neurons from ischemia-induced degeneration. | Nabi Shamsaei Mehdi Khaksari Sohaila Erfani Hamid Rajabi Nahid Aboutaleb | 2015 | Neural Regeneration Research2015，10，8： | 7 |
| 5 | Nosocomial Pneumonia After Acute Stroke: Implications for Neurological Intensive Care Medicine显示文摘 | Ruediger Hilker Carsten Poetter Nahide Findeisen Jan Sobesky Andreas Jacobs Michael Neveling Wolf-Dieter Heiss | 2003 | Stroke: Journal of the American Heart Association2003，，4： | 6 |
| 6 | Assessment of the Acute Effects of DEE (Diesel Exhaust Emitted) on Blood Parameters in Guinea Pigs Cavia porcellus显示文摘 | Ayoub Bazzaz Nahid Nassir A1-Manea | 2012 | Journal of Environmental Science and Engineering(A)2012，1，5： | 5 |
| 7 | Plastid genome sequences of legumes reveal parallel inversions and multiple losses of rps16 in papilionoids显示文摘迄今为止,荚的公开可得到的质体染色体通常被限制了到亚科 Papilionoideae。这里,我们报导跨越所有三个亚科的荚的 13 个新质体染色体。代表 Caesalpinioideae 和 Mimosoideae 的染色体高度在基因内容和基因顺序被保存,类似于祖先的被子植物染色体组织。然而,在 Papilionoideae 以内的染色体首先在大单个拷贝区域在九个 intergenic 分隔符由于删除减少了尺寸。我们的学习也显示 rps16 独立地在荚被失去了至少五次,与在 papilionoids 之中散布的另外的基因和 intron 损失。另外,从在 papilionoids, Lupinus 和 Robinia 以内的二个不同的系的类,分别地有 36 和 39 kb 的平行倒置。当它看起来被 29 bp 重复在二 trnS 基因以内引起,这平行倒置是新奇的。这次重复在显示为在更多的种类在场的这倒置有潜力的所有可得到的荚质体染色体是在场的。homoplasious 倒置的这个案例也是一些倒置事件不能是可靠种系发生的标记的证据。 | Erika N. Schwarz Tracey A. Ruhlman Jamal S. M. Sabir Nahid H. Hajrah Njud S. Alharbi Abdulrahman L. AI-Malki C. Donovan Bailey Robert K. Jansen | 2015 | Journal of Systematics and Evolution2015，53，5： | 5 |
| 8 | Review on herbal medicine on brain ischemia and reperfusion显示文摘Brain ischemia and reperfusion is the leading cause of serious and long-range disability in the world. Clinically significant changes in central nervous system function are observed following brain ischemia and reperfusion. Stroke patients exhibit behavioral, cognitive,emotional, affective and electrophysiological changes during recovery phase. Brain injury by transient complete global brain ischemia or by transient incomplete brain ischemia afflicts a very large number of patients in the world with death or permanent disability. In order to reduce this damage, we must sufficiently understand the mechanisms involved in brain ischemia and reperfusion and repair to design clinically effective therapy.Cerebral ischemia and reperfusion is known to induce the generation of reactive oxygen species that can lead to oxidative damage of proteins, membrane lipids and nucleic acids.A decrease in tissue antioxidant capacity, an increase in lipid peroxidation as well as an increase in lipid peroxidation inhibitors have been demonstrated in several models of brain ischemia. This paper reviews the number of commonly used types of herbal medicines effective for the treatment of stroke. The aim of this paper was to review evidences from controlled studies in order to discuss whether herbal medicine can be helpful in the treatment of brain ischemia and reperfusion. | Nahid Jivad Zahra Rabiei | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 5 |
| 9 | Safety and predictors of adherence of a new rehabilitation program for older women with congestive heart failure显示文摘ObjectivesTo 与充血的心失败(CHF ) 为老妇人估计一个心脏的康复节目的安全并且决定有 CHF 的超过 65 岁的某些因素影响 adherence.MethodsWomen 是否出席了 physiotherapist 监督的一个锻练节目。生活的质量被纽约心协会(NYHA ) 班被明尼苏达生活与心失败问询表(MLHFQ ) 和疾病的严厉测量。题目会议被分类进出席了 90% 的那些或更多,出席了不到 90%sessions.ResultsFifty 一个题目的那些被学习。八个题目没出席任何会议。43 个参加者,出席的会议的平均百分比是 87% 。在年龄, MLHFQ 或 NYHA 班的二个组之间没有重要差别。仅仅从有的 280 参加者 attendances.ConclusionsThe 节目有一个不利事件在这张人口的坚持的高水平。班没在会话出席上影响的年龄, MLHFQ 或 NYHA。我们的数据建议这个节目为这张人口是安全的。进一步的研究被需要决定出席的另外的预言者和安全问题和长期的坚持的考试在这张人口锻练。 | Nahid A. Azad Kathy Bouchard Alain Mayhew Maureen Carter Frank J. Molnar | 2012 | Journal of Geriatric Cardiology2012，9，3： | 4 |
| 10 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 11 | Biopsy-driven diagnosis in infants with cholestatic jaundice in Iran显示文摘AIM:To determine the frequencies of diagnoses confirmed by liver biopsy in infants with cholestasis in an Iranian pediatric hospital.METHODS:This was a retrospective study conducted in a tertiary referral children’s hospital in Iran.We retrieved all pathology reports of liver biopsies from children less than two years of age who had presented for evaluation of cholestatic jaundice from March 2001to March 2011.Additional specimen samples obtained from archived pathology blocks were reviewed by a pathologist blinded to the final diagnosis.These results were compared with the pathology reports from chart records to ensure consensus and eliminate any inconsistencies in final diagnoses.A structured checklist was used to gather information on multiple variables including age,sex,gestational age at birth,birth weight,age at which hyperbilirubinemia manifested,presence and identification of associated anomalies,clinical manifestations,and histological findings from liver biopsies.The baseline data are reported using descriptive statistics,and differences between groups were assessed by Fisher’s exact test and Student’s t test when indicated.RESULTS:Fifty-five cases(28 females;27 males)of infantile cholestasis(IC)were included in this study.The mean serum total bilirubin and direct bilirubin at presentation were 13.6±5.9 and 7.3±3.4,respectively.Forty cases(72.7%)were the product of term pregnancies.Common associated clinical findings were acholic stool in 33 cases(60.0%),hepatomegaly in30 cases(54.5%),and dark-colored urine in 21 cases(38.2%).Biliary atresia(BA)was the most frequent diagnosis,found in 32 cases(58.2%),followed by intrahepatic bile duct paucity found in 6 cases(10.9%),metabolic disease in 6 cases(10.9%),idiopathic neonatal hepatitis in 5 cases(9.1%),choledochal cyst in2 cases(3.6%),liver cirrhosis in 2 cases(3.6%),and progressive familial intrahepatic cholestasis and portal fibrosis each in 1 case(1.8%).The mean times for jaundice onset and liver biopsy were 43.8 and 102.0 d,respectively.In BA,the mean age at jaundice presentation was 21 d and for liver biopsy was 87.5 d,representing a mean delay of 66.5 d.CONCLUSION:A significant delay was found between IC presentation and liver biopsy,which is detrimental in conditions that can cause irreversible liver damage,such as BA. | Elham Talachian Ali Bidari Mitra Mehrazma Nahid Nick-khah | 2014 | World Journal of Gastroenterology2014，20，4： | 3 |
| 12 | Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini(L.) Skeels seeds:A diabetic rat model study显示文摘Objective: To evaluate the effect of methanolic extract of Syzygium cumini(L.) Skeels(S. cumini) seeds on the major organs in an animal model of diabetes through biochemical and histopathological studies.Methods: The methanolic extracts of S. cumini seeds(100 and 200 mg/kg body weight) were administered to alloxan-induced diabetic rats daily, with fasting blood glucose levels being measured by glucometry at one-day interval for a duration of two weeks. Biochemical assays to evaluate changes in the functions of the heart, liver,pancreas and kidney were carried out. Histopathological changes in the diabetic rat organs(pancreas, liver, heart, kidney and spleen) were also observed after the 14 days of treatment with the extracts.Results: Oral administration of methanolic extracts of S. cumini seeds(100 and 200 mg/kg body weight), with gliclazide as a positive control(25 mg/kg), showed beneficial effects including lowering blood glucose levels(P < 0.001), improved heart and liver functions, and hyperlipidemia due to diabetes. At 200 mg/kg, the extracts reversed cardiac and liver damage caused by alloxan.Conclusions: In addition to the anti-hyperglycemic activity of methanolic extracts of S. cumini seeds, the extracts demonstrates potential to minimize cardiac and hepatic complications. | Sumaiya Nahid Kishor Mazumder Zillur Rahman Saiful Islam Md. Humayun Rashid Philip Grey Kerr | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，2： | 2 |
| 13 | A Different Light in Predicting Ungauged Basins: Regionalization Approach Based on Eastern USA Catchments显示文摘 | Syed Abu Shoaib Andras Bardossy Thorsten Wagener Yingchun Huang Nahid Sultana | 2013 | Journal of Civil Engineering and Architecture2013，7，3： | 2 |
| 14 | Passiflora plastome sequencing reveals widespread genomic rearrangements显示文摘Although past studies have included Passiflora among angiosperm lineages with highly rearranged plastid genomes (plastomes),knowledge about plastome organization in the genus is limited.So far only one draft and one complete plastome have been published.Expanded sampling of Passiflora plastomes is needed to understand the extent of the genomic rearrangement in the genus,which is also unusual in having biparental plastid inheritance and plastome-genome incompatibility.We sequenced 15 Passiflora plastomes using either Illumina paired-end or shotgun cloning and Sanger sequencing approaches.Assembled plastomes were annotated using Dual Organellar GenoMe Annotator (DOGMA)and tRNAscan-SE.The Populus trichocarpa plastome was used as a reference to estimate genomic rearrangements in Passifloru by performing whole genome alignment in progressiveMauve.The phylogenetic distribution of rearrangements was plotted on the maximum likelihood tree generated from 64 plastid encoded protein genes.Inverted repeat (IR)expansion/contraction and loss of the two largest hypothetical open reading frames,ycf1 and ycf2,account for most plastome size variation,which ranges from 139 262 base pairs (bp)in P.biflora to 161 494 bp in P.pittieri.Passifloru plastomes have experienced numerous inversions,gene and intron losses along with multiple independent IR expansions and contractions resulting in a distinct organization in each of the three subgenera examined.Each Passiflora subgenus has a unique plastome structure in terms of gene content,order and size.The phylogenetic distribution of rearrangements shows that Passiflora has experienced widespread genomic changes,suggesting that such events may not be reliable phylogenetic markers. | Samar O.Rabah Bikash Shrestha Nahid H.Hajrah Mumdooh J.Sabir Hesham F.Alharby Mernan J.Sabir Alawiah M.Alhebshi Jamal S.M.Sabir Lawrence E.Gilbert Tracey A.Ruhlman Robert K.Jansen | 2019 | Journal of Systematics and Evolution2019，57，1： | 2 |
| 15 | Impact of two types of sodium and ultrafiltration profiles on int-radialytic hyportension in hemodialysis patients显示文摘 | Nahid S Mansoor G | 2008 | IJNMR Autumn2008，13，4： | 1 |
| 16 | Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling显示文摘 | Nahid MA Satoh M Chan EK | | 0，，： | 1 |
| 17 | Polysiloxane-based core-shell microspheres for toughening of epoxy resins显示文摘 | Prasun Kumar Roy Nahid Iqbal Devendra Kumar Chitra Rajagopal | 2014 | Journal of Polymer Research2014，，1： | 1 |
| 18 | High prevalence of Vitamin D deficiency among pregnant women and their newborns in an Iranin population 显示文摘 | ALINAGHI K FARANAK S NAHID J | 2009 | N Engl J Med2009，18，6： | 1 |
| 19 | Trend of Increase in the Incidence of Acute Myocardial Infarction in a Japanese Population显示文摘 | Nahid Rumana Yoshikuni Kita Tanvir Chowdhury Turin | 2008 | Am J Epidemiol2008，167，： | 1 |
| 20 | Analysis of EEG records in an epileptic patient using wavelet transform显示文摘 | Ziqin Zhou Nahid Dadmehr | 2003 | Journal of Neuroscience Methods2003，6987，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员