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| 1 | Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”显示文摘MK615, a compound extracted from the Japanese apricot 'Prunus mume ' has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis appeared.Sorafenib was administered, but was not effective.Then, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects. | Takashi Hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 2 | Statistical Analysis of Fragility Curves显示文摘 | Masanobu Shinozuka M. Q. Feng Jongheon Lee Toshihiko Naganuma | 2000 | Journal of Engineering Mechanics2000，，12： | 4 |
| 3 | Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted enteroscopy显示文摘BACKGROUND Capsule endoscopy and balloon-assisted enteroscopy(BAE) enable visualization of rare small bowel conditions such as small intestinal malignant tumors.However,details of the endoscopic characteristics of small intestinal malignant tumors are still unknown.AIM To elucidate the endoscopic characteristics of small intestinal malignant tumors.METHODS From March 2005 to February 2017,1329 BAE procedures were performed at Keio University Hospital. Of these procedures,malignant tumors were classified into three groups,Group 1: epithelial tumors including primary small intestinal cancer,metastatic small intestinal cancer,and direct small intestinal invasion by an adjacent organ cancer; Group 2: small intestinal malignant lymphoma; and Group 3,small intestinal gastrointestinal stromal tumors. We systematically collected clinical and endoscopic data from patients' medical records to determine the endoscopic characteristics for each group.RESULTS The number of patients in each group was 16(Group 1),23(Group 2),and 6(Group 3),and the percentage of solitary tumors was 100%,43.5%,and 100%,respectively(P < 0.001). Patients' clinical background parameters including age,symptoms,and laboratory data were not significantly different between the groups. Seventy-five percent of epithelial tumors(Group 1) were located in the upper small intestine(duodenum and ileum),and approximately 70% of gastrointestinal stromal tumors(Group 3) were located in the jejunum. Solitary protruding or mass-type tumors were not seen in malignant lymphoma(Group2)(P < 0.001). Stenosis was seen more often in Group 1,(68.8%,27.3%,and 0%;Group 1,2,and 3,respectively; P = 0.004). Enlarged white villi inside and/or surrounding the tumor were seen in 12.5%,54.5%,and 0% in Group 1,2,and 3,respectively(P = 0.001).CONCLUSION The differential diagnosis of small intestinal malignant tumors could be tentatively made based on BAE findings. | Tomofumi Horie Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Kenji JL Limpias Kamiya Ryoichi Miyanaga Shinta Mizuno Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Masayuki Shimoda Haruhiko Ogata Takanori Kanai | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 4 |
| 4 | Endoscopic removal of foreign bodies:A retrospective study in Japan显示文摘BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical problems.Methods to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success rate.However,to date,no studies have evaluated the endoscopic management of FBs in Japan.AIM To elucidate level of safety and efficacy in the endoscopic management of FBs and FBI.METHODS A total of 215 procedures were performed at Keio University Hospital between November 2007 and August 2018.Data were collected from medical charts,and endoscopic details were collected from an endoscopic reporting system.Procedures performed with a flexible gastrointestinal endoscope were only taken into account.Patients who underwent a technique involving FB or FBI from the digestive tract were only included.Data on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed retrospectively.RESULTS Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in outpatients.The most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the cases.The most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was 100%,and complication were observed in only one case(0.5%).CONCLUSION Endoscopic management of FBs and FBI in our Hospital is extremely safe and effective. | Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，1： | 3 |
| 5 | Diagnostic problems in two-dimensional shear wave elastography of the liver显示文摘Two-dimensional shear wave elastography(2D-SWE)is used in the clinical setting for observation of the liver.Unfortunately,a wide spectrum of artifactual images are frequently encountered in 2D-SWE,the precise mechanisms of which remain incompletely understood.This review was designed to present many of the artifactual images seen in 2D-SWE of the liver and to analyze them by computer simulation models that support clinical observations.Our computer simulations yielded the following suggestions:(1)When performing 2D-SWE in patients with chronic hepatic disease,especially liver cirrhosis,it is recommended to measure shear wave values through the least irregular hepatic surface;(2)The most useful 2D-SWE in patients with focal lesion will detect lesions that are poorly visible on B-mode ultrasound and will differentiate true tumors from pseudo-tumors(e.g.,irregular fatty change);and(3)Measurement of shear wave values in the area posterior to a focal lesion must be avoided. | Hiroko Naganuma Hideaki Ishida Atsushi Uno Hiroshi Nagai Hidekatsu Kuroda Masahiro Ogawa | 2020 | World Journal of Radiology2020，12，5： | 3 |
| 6 | Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study显示文摘 | Naoki Hosoe Katsuyoshi Matsuoka Makoto Naganuma Yosuke Ida Yuka Ishibashi Kayoko Kimura Kazuaki Yoneno Shingo Usui Kazuhiro Kashiwagi Tadakazu Hisamatsu Nagamu Inoue Takanori Kanai Hiroyuki Imaeda Haruhiko Ogata Toshifumi Hibi | 2013 | J Gastroenterol Hepatol2013，，7： | 3 |
| 7 | High-performance liquid chromatographic determination of loxoprofen and its diastereomeric alcohol metabolites in biological fluids by fluorescence labeling with 4-bromomethyl-6,7-methylenedioxycoumarin 显示文摘 | Naganuma H Kawahara Y | 1990 | J Chromatogr1990，530，： | 2 |
| 8 | Statistical Analysis of Fragility Curves显示文摘 | Masanobu Shinozuka M. Q. Feng Jongheon Lee Toshihiko Naganuma | 2000 | Journal of Engineering Mechanics2000，，12： | 2 |
| 9 | Isolation, characterization and molecular evolution of a novel pearl shell lectin from a marine bivalve Pteria penguin 显示文摘 | Naganuma T Ogawa T Hirabayashi J | 2006 | Mol Divers2006，10，4： | 1 |
| 10 | Topical trans-4-aminomethylcy- clohexane carboxylic acid prevents ultravio-let radiation- induced pigmentation 显示文摘 | Maeda K Naganuma M | 1998 | J Photochem Photobiol B1998，47，23： | 1 |
| 11 | Peripheral vasodilatory dysfunction in adult patients with congenital heart disease and severely elevated pulmonary vascular resistance 显示文摘 | Nakamura M Yoshida H Naganuma Y | 2002 | Angiology2002，53，6： | 1 |
| 12 | Two cases of top of the basilar syndrome with onset seizure显示文摘 | Naganuma M Hashimoto Y Matsuura Y | 2005 | Rinsho Shinkeigaku2005，45，： | 1 |
| 13 | Early neurological deteriora- tion within 24 hours after intravenous rt - PA therapy for stroke pa- tients:the Stroke Acute Management with Urgent Risk Factor As- sessment and Improvement rt - PA Registry 显示文摘 | Mori M Naganuma M 0kada Y | 2012 | Cerebrovasc Dis2012，34，2： | 1 |
| 14 | Low-temperature formation of ternary carbide Fe3M3C(M=Mo,W) assisted by mechanical activation显示文摘 | Tsuchida Takeshi Suzuki Kengo Naganuma Hiroshi | 2001 | Solid State Ionics2001，，： | 1 |
| 15 | Thymidine phosphorylase levels as a prognostic factor in renal cell carcinoma显示文摘 | Wada S Yoshimura R Naganuma T | 2003 | BJU Int2003，91，： | 1 |
| 16 | Blogs in English language teaching and learning: pedagogical uses and student respon- ses显示文摘 | Blackstone B Spiri J Naganuma N | 2007 | Reflections on English Language Teaching2007，6，2： | 1 |
| 17 | New aspects of cerebrovascular diseases in dialysis patients显示文摘 | Naganuma T Takemoto Y | 2015 | Contrib Nephrol2015，185，： | 1 |
| 18 | Feeding habits of skipjack tuna (Katsuwonus pelamis Linnaeus ) caught by pole and line and the state of young skipjack tuna distribution in the tropical seas of the western Pacific Ocean显示文摘 | Iizuka K Asano M Naganuma A | 1989 | Aquatic ecology1989，，51： | 1 |
| 19 | Quantification of thrombospondin-1 secretion and expression of αvβ3 and α3β1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells显示文摘 | Hirofumi Naganuma M.D. Ph.D. Eiji Satoh Takayuki Asahara Kenichi Amagasaki Arata Watanabe Hiroki Satoh Katsuhiro Kuroda Lei Zhang Hideaki Nukui | 2004 | Journal of Neuro - Oncology2004，，3： | 1 |
| 20 | A NOTCH3- mediated squamous cell differentiation program limits ex- pansion of EMT-competent ceils that express the ZEB tran- scription factors显示文摘 | Ohashi S Natsuizaka M Naganuma S | 2011 | Caner Res2011，71，： | 1 |
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