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| 1 | Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects显示文摘Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain elusive.Enhanced relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in CSVD.Diffusion tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter damage.However,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical use.In this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals. | Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha | 2022 | World Journal of Clinical Cases2022，10，24： | 2 |
| 2 | Population based study of late onset cerebellar ataxia in south east Wales 显示文摘 | Muzaimi M B Thomas J Plamer-Smith S | 2004 | J Neurol Neurosurg Psychiat2004，75，8： | 1 |
| 3 | Better Glasgow outcomescore,cerebral perfusion pressure and focal brain oxygenation inseverely traumatized brain following direct regional brain hypothermiatherapy:a prospective randomized study 显示文摘 | Idris Z Zenian MS Muzaimi M | 2014 | Asian JNeurosurg2014，9，3： | 1 |
| 4 | Better Glasgow outcome score, cerebral perfusion pressure and focal brain oxygenation in severely traumatized brain following direct regional brain hypothermia therapy : A prospective randomized study 显示文摘 | Idris Z Zenian MS Muzaimi M | 2014 | Asian J Neurosurg2014，9，3： | 1 |
| 5 | Population based study of late onset cerebellar ataxia in south east Wales显示文摘 | Muzaimi MB Thomas J Palmer-Smith S | | 0，，： | 1 |
| 6 | Task specific focal dystonia:a presentation of spinocerebellar ataxia type 6显示文摘 | Wiles CM Robertson NP | 2003 | Journal of Neurology Neurosurgery & Psychiatry2003，74，： | 1 |
| 7 | Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats显示文摘 | Ammar Imad Hazim Surash Ramanathan Suhanya Parthasarathy Mustapha Muzaimi Sharif Mahsufi Mansor | 2014 | The Journal of Physiological Sciences2014，，3： | 1 |
| 8 | Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases:a systematic review显示文摘Trehalose,a unique nonreducing crystalline disaccharide,is a potential disease-modifying treatment for neurodegenerative diseases associated with protein misfolding and aggregation due to aging,intrinsic mutations,or autophagy dysregulation.This systematic review summarizes the effects of trehalose on its underlying mechanisms in animal models of selected neurodegenerative disorders(tau pathology,synucleinopathy,polyglutamine tract,and motor neuron diseases).All animal studies on neurodegenerative diseases treated with trehalose published in Medline(accessed via EBSCOhost)and Scopus were considered.Of the 2259 studies screened,29 met the eligibility criteria.According to the SYstematic Review Center for Laboratory Animal Experiment(SYRCLE)risk of bias tool,we reported 22 out of 29 studies with a high risk of bias.The present findings support the purported role of trehalose in autophagic flux and protein refolding.This review identified several other lesser-known pathways,including modifying amyloid precursor protein processing,inhibition of reactive gliosis,the integrity of the blood-brain barrier,activation of growth factors,upregulation of the downstream antioxidant signaling pathway,and protection against mitochondrial defects.The absence of adverse events and improvements in the outcome parameters were observed in some studies,which supports the transition to human clinical trials.It is possible to conclude that trehalose exerts its neuroprotective effects through both direct and indirect pathways.However,heterogeneous methodologies and outcome measures across the studies rendered it impossible to derive a definitive conclusion.Translational studies on trehalose would need to clarify three important questions:1)bioavailability with oral administration,2)optimal time window to confer neuroprotective benefits,and 3)optimal dosage to confer neuroprotection. | Kah Hui Yap Shahrul Azmin Suzana Makpol Hanafi Ahmad Damanhuri Muzaimi Mustapha Jemaima Che Hamzah Norlinah Mohamed Ibrahim | 2023 | Neural Regeneration Research2023，18，6： | 0 |
| 9 | 威尔士东南部地区一项关于迟发型小脑共济失调的人群调查研究 | Muzaimi M.B. Thomas J. Palmer-Smith S. N.P. Robertson 罗勇 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，1： | 0 |
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